NP_068811.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,365 Da
NCBI Official Full Name
retinoic acid receptor RXR-beta isoform 2
NCBI Official Synonym Full Names
retinoid X receptor beta
NCBI Official Synonym Symbols
NR2B2; DAUDI6; RCoR-1; H-2RIIBP [Similar Products]
NCBI Protein Information
retinoic acid receptor RXR-beta
UniProt Protein Name
Retinoic acid receptor RXR-beta
UniProt Synonym Protein Names
Nuclear receptor subfamily 2 group B member 2; Retinoid X receptor beta
UniProt Synonym Gene Names
UniProt Entry Name
RXRB_HUMAN
NCBI Summary for RXRB
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
UniProt Comments for RXRB
RXRB: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. Specifically binds 9-cis retinoic acid (9C-RA). Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Expressed in a variety of tumor cell lines. Belongs to the nuclear hormone receptor family. NR2 subfamily.
Protein type: DNA-binding; Nuclear receptor
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: nucleoplasm; nucleus
Molecular Function: ligand-dependent nuclear receptor activity; protein binding; protein heterodimerization activity; retinoic acid receptor binding; retinoid-X receptor activity; steroid hormone receptor activity; thyroid hormone receptor binding; thyroid hormone receptor coactivator activity; transcription coactivator activity; transcription factor activity; vitamin D receptor binding; zinc ion binding
Biological Process: positive regulation of transcription from RNA polymerase II promoter; regulation of myelination; retinoic acid receptor signaling pathway; steroid hormone mediated signaling; transcription initiation from RNA polymerase II promoter
Research Articles on RXRB
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Products associated with anti-RXRB antibody
Pathways associated with anti-RXRB antibody
Diseases associated with anti-RXRB antibody
Organs/Tissues associated with anti-RXRB antibody
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