Q92736.3
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Ryanodine receptor 2
NCBI Official Synonym Full Names
ryanodine receptor 2
NCBI Official Synonym Symbols
RyR; ARVC2; ARVD2; RYR-2; VTSIP [Similar Products]
NCBI Protein Information
ryanodine receptor 2
UniProt Protein Name
Ryanodine receptor 2
UniProt Synonym Protein Names
Cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; Type 2 ryanodine receptor
UniProt Synonym Gene Names
NCBI Summary for RYR2-S2815
This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008]
UniProt Comments for RYR2-S2815
RYR2: ryanodine receptor calcium release channel. Regulates communication between transverse-tubules and sarcoplasmic reticulum. Contraction of cardiac muscle is triggered by release of calcium ions from SR following depolarization of T-tubules. Phosphorylation by PKA dissociates FKBP12.6 from RYR2. Two splice isoforms have been described.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 1q43
Cellular Component: membrane; plasma membrane; protein complex; sarcoplasmic reticulum; sarcoplasmic reticulum membrane; Z disc
Molecular Function: calcium channel activity; calcium ion binding; calcium-induced calcium release activity; calcium-release channel activity; calmodulin binding; enzyme binding; identical protein binding; protein binding; ryanodine-sensitive calcium-release channel activity
Biological Process: calcium ion transport; calcium-mediated signaling; cardiac muscle contraction; cellular calcium ion homeostasis; cytosolic calcium ion homeostasis; detection of calcium ion; positive regulation of heart rate; positive regulation of sequestering of calcium ion; regulation of heart rate; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; release of sequestered calcium ion into cytosol; response to caffeine; response to hypoxia; response to muscle activity; response to redox state
Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 2; Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/or Dilated Cardiomyopathy
Research Articles on RYR2-S2815
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Products associated with anti-RYR2-S2815 antibody
Pathways associated with anti-RYR2-S2815 antibody
Diseases associated with anti-RYR2-S2815 antibody
Disease Name |
Pubmed Publications |
VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1, WITH OR WITHOUT ATRIAL DYSFUNCTION AND/OR DILATED CARDIOMYOPATHY Antibodies |
>18625 publications with RYR2-S2815 and VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1, WITH OR WITHOUT ATRIAL DYSFUNCTION AND/OR DILATED CARDIOMYOPATHY |
Heart Diseases Antibodies |
>960 publications with RYR2-S2815 and Heart Diseases |
Arrhythmias, Cardiac Antibodies |
>568 publications with RYR2-S2815 and Arrhythmias, Cardiac |
Nervous System Diseases Antibodies |
>451 publications with RYR2-S2815 and Nervous System Diseases |
Heart Failure Antibodies |
>445 publications with RYR2-S2815 and Heart Failure |
Tachycardia Antibodies |
>353 publications with RYR2-S2815 and Tachycardia |
Tachycardia, Ventricular Antibodies |
>335 publications with RYR2-S2815 and Tachycardia, Ventricular |
Disease Models, Animal Antibodies |
>234 publications with RYR2-S2815 and Disease Models, Animal |
Cardiomyopathies Antibodies |
>153 publications with RYR2-S2815 and Cardiomyopathies |
Cardiomegaly Antibodies |
>110 publications with RYR2-S2815 and Cardiomegaly |
Organs/Tissues associated with anti-RYR2-S2815 antibody
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