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anti-IQGAP2 antibody :: Rabbit Rac1/Cdc42 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS622474 anti-IQGAP2 antibody
Unit / Price
0.02 mL  /  $385 +1 FREE 8GB USB
0.1 mL  /  $540 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Rac1/Cdc42 (IQGAP2), Polyclonal Antibody

 Also Known As   

Rac1/Cdc42

 Product Synonym Names    Anti -Rac1/Cdc42
 Product Gene Name   

anti-IQGAP2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 5; NC_000005.9 (75699131..76003957). Location: 5q13.3
 OMIM    605401
 3D Structure    ModBase 3D Structure for Q13576
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Monkey, Mouse, Rat
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 Specificity    Recognizes endogenous levels of total rac1 and cdc42 protein. Based on sequence similarities, the antibody may react with rac2 and rac3. The antibody does not cross-react with rhoA, rhoB or rhoC. Species crossreactivity: Human, muse, rat and monkey
 Purity/Purification    Affinity Purified
Purified by Protein A and peptide affinity chromatography.
 Form/Format    Supplied as a liquid in 10mM sodium HEPES pH 7.5, 150mM NaCl, 0.1mg/ml BSA, 50% glycerol.
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 Immunogen    Synthetic peptide corresponding to residues near the amino termini of human rac1 and cdc42.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-IQGAP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IQGAP2 antibody

   Rac and Cdc42 are members of the Rho-GTPase family. In mammals, Rac exists as three isoforms, Rac1, Rac2 and Rac3, which are highly similar in sequence. Rac1 and Cdc42, the most widely studied of this group, are ubiquitously expressed. Rac2 is expressed in cells of hematopoietic origin, and Rac3, while highly expressed in brain, is also found in many other tissues. Rac and Cdc42 play key signaling roles in cytoskeletal reorganization, membrane trafficking, transcriptional regulation, cell growth and development (1). GTP binding stimulates the activity of Rac/Cdc42, and the hydrolysis of GTP to GDP through the protein's intrinsic GTPase activity, rendering it inactive. GTP hydrolysis is aided by GTPase activating proteins (GAPs), while exchange of GDP for GTP is facilitated by guanine nucleotide exchange factors (GEFs). Another level of regulation is achieved through the binding of RhoGDI, a guanine nucleotide dissociation inhibitor, which retains Rho family GTPases, including Rac and Cdc42, in their inactive GDP-bound state (2,3).
 Product Categories/Family for anti-IQGAP2 antibody    Antibodies; Abs to Protein Kinases
 Applications Tested/Suitable for anti-IQGAP2 antibody   

Western Blot (WB)

 Application Notes for anti-IQGAP2 antibody    Suitable for use in Western Blot.
Dilution: Western Blot: 1:1000
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NCBI/Uniprot data below describe general gene information for IQGAP2. It may not necessarily be applicable to this product.
 NCBI GI #    116089337
 NCBI GeneID    10788
 NCBI Accession #    NP_006624.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006633.2 [Other Products]
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 UniProt Primary Accession #    Q13576 [Other Products]
 UniProt Secondary Accession #    A8K4V1; B7Z8A4 [Other Products]
 UniProt Related Accession #    Q13576 [Other Products]
 Molecular Weight    180,578 Da [Similar Products]
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 NCBI Official Full Name    ras GTPase-activating-like protein IQGAP2
 NCBI Official Synonym Full Names    IQ motif containing GTPase activating protein 2
 NCBI Official Symbol    IQGAP2 [Similar Products]
 NCBI Protein Information    ras GTPase-activating-like protein IQGAP2
 UniProt Protein Name    Ras GTPase-activating-like protein IQGAP2
 Protein Family    Ras GTPase-activating-like protein
 UniProt Gene Name    IQGAP2 [Similar Products]
 UniProt Entry Name    IQGA2_HUMAN
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 NCBI Summary for IQGAP2    This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IQGAP2    IQGAP2: Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin. Isoform 2 expression is enhanced in testis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; G protein regulator, misc.

Chromosomal Location of Human Ortholog: 5q13.3

Cellular Component: filamentous actin; microtubule; microvillus; cell surface; lamellipodium; cytoplasm; actin cytoskeleton; filopodium

Molecular Function: calmodulin binding; actin filament binding; Rho GTPase binding; phosphatidylinositol-3,4,5-triphosphate binding; Rac GTPase binding; actin binding; GTPase inhibitor activity

Biological Process: small GTPase mediated signal transduction; negative regulation of catalytic activity; signal transduction
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 Research Articles on IQGAP2    1. observations strongly indicate that IQGAP2 is a surveillance type of tumour suppressor for prostate cancer
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IQGAP2 antibodyPathways associated with anti-IQGAP2 antibody
 Reference Product  PubMed Publications
 CDC42 antibody  >14 publications with IQGAP2 and CDC42
 RAC1 antibody  >8 publications with IQGAP2 and RAC1
 GRM7 antibody  >1 publications with IQGAP2 and GRM7
 Products by Pathway  Pathway Diagram
 G13 Signaling Pathway antibodies  G13 Signaling Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram
Diseases associated with anti-IQGAP2 antibodyOrgans/Tissues associated with anti-IQGAP2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >14 publications with IQGAP2 and Neoplasms
 Carcinoma, Hepatocellular Antibodies  >8 publications with IQGAP2 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >7 publications with IQGAP2 and Liver Diseases
 Liver Neoplasms Antibodies  >5 publications with IQGAP2 and Liver Neoplasms
 Adenocarcinoma Antibodies  >5 publications with IQGAP2 and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >1 publications with IQGAP2 and Cardiovascular Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with IQGAP2 and Cell Transformation, Neoplastic
 Poisoning Antibodies  >1 publications with IQGAP2 and Poisoning
 Fatty Liver Antibodies  >1 publications with IQGAP2 and Fatty Liver
 Hemolysis Antibodies  >1 publications with IQGAP2 and Hemolysis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >12 publications with IQGAP2 and Liver
 Blood Antibodies  >4 publications with IQGAP2 and Blood
 Stomach Antibodies  >4 publications with IQGAP2 and Stomach
 Embryonic Tissue Antibodies  >3 publications with IQGAP2 and Embryonic Tissue
 Prostate Antibodies  >2 publications with IQGAP2 and Prostate
 Pancreas Antibodies  >1 publications with IQGAP2 and Pancreas
 Muscle Antibodies  >1 publications with IQGAP2 and Muscle
 Brain Antibodies  >1 publications with IQGAP2 and Brain
 Testis Antibodies  >1 publications with IQGAP2 and Testis
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