NP_037267.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
115,440 Da
NCBI Official Full Name
ras GTPase-activating protein 1
NCBI Official Synonym Full Names
RAS p21 protein activator 1
NCBI Official Synonym Symbols
NCBI Protein Information
ras GTPase-activating protein 1
UniProt Protein Name
Ras GTPase-activating protein 1
UniProt Synonym Protein Names
Ras p21 protein activator; p120GAP
UniProt Synonym Gene Names
NCBI Summary for RASA1
may play a role in Ras GTPase mediated signal transduction; may be involved in cell proliferation and cell migration [RGD, Feb 2006]
UniProt Comments for RASA1
RASA1: a GTPase activator for normal RAS p21 but not its oncogenic counterpart, converting it to the putatively inactive GDP-bound state. Acting as a suppressor of RAS function, it enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Two alternatively spliced isoforms have been described.
Protein type: GAPs; GAPs, Ras; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 2q11
Cellular Component: cytosol; membrane; nuclear membrane; plasma membrane; ruffle
Molecular Function: glycoprotein binding; GTPase activator activity; GTPase binding; kinase binding; platelet-derived growth factor receptor binding; protein binding; protein complex binding; protein kinase B binding; receptor binding; receptor tyrosine kinase binding; transcription factor binding
Biological Process: blood vessel morphogenesis; cytokinesis after mitosis; male genitalia development; negative regulation of cell adhesion; negative regulation of cell-matrix adhesion; negative regulation of neuron apoptosis; negative regulation of Ras protein signal transduction; positive regulation of fibroblast proliferation; positive regulation of glucose import; positive regulation of GTPase activity; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein amino acid phosphorylation; regulation of actin filament polymerization; response to drug; response to insulin stimulus; signal transduction; vasculogenesis
Research Articles on RASA1
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Pathways associated with anti-RASA1 antibody
Diseases associated with anti-RASA1 antibody
Organs/Tissues associated with anti-RASA1 antibody
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