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anti-erbB-2 antibody :: Rabbit anti-Human Receptor tyrosine-protein kinase erbB-2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1489194
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Receptor tyrosine-protein kinase erbB-2, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Receptor tyrosine-protein kinase erbB-2 polyclonal Antibody, FITC

 Product Synonym Names    Metastatic lymph node gene 19 protein; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD_antigen; ERBB2; HER2; MLN19; NEU; NGL
 Product Gene Name   

anti-erbB-2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    137215
 3D Structure    ModBase 3D Structure for P04626
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    FITC
 Immunogen    Recombinant human Receptor tyrosine-protein kinase erbB-2 protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-31153 / sc-31154 / sc-23864 / sc-134481 / sc-284
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-erbB-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-erbB-2 antibody

   Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
 Applications Tested/Suitable for anti-erbB-2 antibody   

ELISA (EIA)

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 Immunohistochemistry (IHC) of anti-erbB-2 antibody    Immunohistochemistry of paraffin-embedded human prostate at dilution of 1:100
anti-erbB-2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-erbB-2 antibody    Immunohistochemistry of paraffin-embedded human kidney at dilution of 1:100
anti-erbB-2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for erbB-2. It may not necessarily be applicable to this product.
 NCBI GI #    54792098
 NCBI GeneID    2064
 NCBI Accession #    NP_001005862.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001005862.2 [Other Products]
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 UniProt Primary Accession #    P04626 [Other Products]
 UniProt Secondary Accession #    Q14256; Q6LDV1; Q9UMK4; B2RZG3; B4DHN3; X5D2V5 [Other Products]
 UniProt Related Accession #    P04626 [Other Products]
 Molecular Weight    97,382 Da
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 NCBI Official Full Name    receptor tyrosine-protein kinase erbB-2 isoform b
 NCBI Official Synonym Full Names    erb-b2 receptor tyrosine kinase 2
 NCBI Official Symbol    ERBB2 [Similar Products]
 NCBI Official Synonym Symbols   
NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu
[Similar Products]
 NCBI Protein Information    receptor tyrosine-protein kinase erbB-2
 UniProt Protein Name    Receptor tyrosine-protein kinase erbB-2
 UniProt Synonym Protein Names   
Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD_antigen: CD340
 Protein Family    Receptor tyrosine-protein kinase
 UniProt Gene Name    ERBB2 [Similar Products]
 UniProt Synonym Gene Names    HER2; MLN19; NEU; NGL; MLN 19 [Similar Products]
 UniProt Entry Name    ERBB2_HUMAN
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 NCBI Summary for erbB-2    This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for erbB-2    HER2: a proto-oncogenic receptor tyrosine kinase of the EGFR family. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. Not activated by EGF, TGF- alpha and amphiregulin. Amplified in breast cancer. Overexpression induces constitutive activity, and the gene is amplified or overexpressed in up to 30% of breast cancers, correlating with poor survival. The antibody Herceptin is approved for treatment of metastatic breast cancer with HER2 amplification/overexpression. Somatic mutations seen in 4% of lung cancers and also in breast, gastric, ovarian cancer and glioblastoma. One SNP shows predisposition to breast and gastric cancer. Inhibitors: Herceptin, lapatinib, PKI-166, EKB-569, CI-1033.

Protein type: Oncoprotein; Membrane protein, integral; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Kinase, protein; Protein kinase, TK; TK group; EGFR family

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: apical plasma membrane; basolateral plasma membrane; cytoplasm; cytoplasmic vesicle; endosome membrane; integral to membrane; myelin sheath; nucleus; perinuclear region of cytoplasm; plasma membrane; receptor complex

Molecular Function: ATP binding; ErbB-3 class receptor binding; growth factor binding; identical protein binding; protein binding; protein C-terminus binding; protein dimerization activity; protein heterodimerization activity; protein phosphatase binding; protein-tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; transmembrane receptor activity; transmembrane receptor protein tyrosine kinase activity

Biological Process: activation of MAPKK activity; axon guidance; cell proliferation; cell surface receptor linked signal transduction; enzyme linked receptor protein signaling pathway; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; heart development; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; motor axon guidance; myelination; negative regulation of immature T cell proliferation in the thymus; nerve growth factor receptor signaling pathway; neuromuscular junction development; oligodendrocyte differentiation; peptidyl-tyrosine phosphorylation; peripheral nervous system development; phosphoinositide 3-kinase cascade; phosphoinositide-mediated signaling; positive regulation of cell adhesion; positive regulation of cell growth; positive regulation of epithelial cell proliferation; positive regulation of GTPase activity; positive regulation of MAP kinase activity; positive regulation of protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase I promoter; positive regulation of transcription from RNA polymerase III promoter; positive regulation of translation; protein amino acid autophosphorylation; protein amino acid phosphorylation; Ras protein signal transduction; regulation of angiogenesis; regulation of microtubule-based process; signal transduction; small GTPase mediated signal transduction; transcription, DNA-dependent; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway; wound healing

Disease: Gastric Cancer; Glioma Susceptibility 1; Lung Cancer
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 Research Articles on erbB-2    1. COX-2 and HER-2 are important markers for invasion and metastasis of colorectal cancer, and they act together to regulate the invasion and metastasis of colorectal cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-erbB-2 antibodyPathways associated with anti-erbB-2 antibody
 Reference Product  PubMed Publications
 EGFR antibody  >3208 publications with erbB-2 and EGFR
 ERBB3 antibody  >892 publications with erbB-2 and ERBB3
 SRC antibody  >421 publications with erbB-2 and SRC
 CTNNB1 antibody  >199 publications with erbB-2 and CTNNB1
 GRB2 antibody  >110 publications with erbB-2 and GRB2
 ERBB2IP antibody  >46 publications with erbB-2 and ERBB2IP
 SHC1 antibody  >37 publications with erbB-2 and SHC1
 PTPN11 antibody  >15 publications with erbB-2 and PTPN11
 UBC antibody  >6 publications with erbB-2 and UBC
 HSP90AA1 antibody  >1 publications with erbB-2 and HSP90AA1
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
Diseases associated with anti-erbB-2 antibodyOrgans/Tissues associated with anti-erbB-2 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >13635 publications with erbB-2 and Breast Neoplasms
 Carcinoma Antibodies  >7174 publications with erbB-2 and Carcinoma
 Adenocarcinoma Antibodies  >3821 publications with erbB-2 and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >3199 publications with erbB-2 and Neoplasm Metastasis
 Recurrence Antibodies  >1893 publications with erbB-2 and Recurrence
 Disease Progression Antibodies  >1802 publications with erbB-2 and Disease Progression
 Neoplasms, Experimental Antibodies  >1790 publications with erbB-2 and Neoplasms, Experimental
 Gastrointestinal Neoplasms Antibodies  >1480 publications with erbB-2 and Gastrointestinal Neoplasms
 Lymphatic Metastasis Antibodies  >1447 publications with erbB-2 and Lymphatic Metastasis
 Carcinogenesis Antibodies  >1398 publications with erbB-2 and Carcinogenesis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2374 publications with erbB-2 and Blood
 Lymph Node Antibodies  >2128 publications with erbB-2 and Lymph Node
 Lung Antibodies  >1532 publications with erbB-2 and Lung
 Stomach Antibodies  >900 publications with erbB-2 and Stomach
 Brain Antibodies  >723 publications with erbB-2 and Brain
 Liver Antibodies  >648 publications with erbB-2 and Liver
 Prostate Antibodies  >526 publications with erbB-2 and Prostate
 Bone Antibodies  >515 publications with erbB-2 and Bone
 Mammary Gland Antibodies  >488 publications with erbB-2 and Mammary Gland
 Heart Antibodies  >471 publications with erbB-2 and Heart
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