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anti-C10orf59 antibody :: Goat Renalase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420455
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Renalase (C10orf59), Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-Renalase (aa 134 to 147) Antibody

 Product Synonym Names    Goat Anti-Renalase (aa 224 to 233) Antibody; renalase; C10orf59; chromosome 10 open reading frame 59; FLJ11218; renalase antibody; C10orf59 antibody; chromosome 10 open reading frame 59 antibody; FLJ11218 antibody; Renalase; Renalase (aa 134 to 147)
 Product Gene Name   

anti-C10orf59 antibody

[Similar Products]
 Antibody/Peptide Pairs    Renalase peptide (MBS425400) is used for blocking the activity of Renalase antibody (MBS420455)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    QINLRDDKWE VSKQ
 OMIM    609360
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Mouse, Rat; Expected from sequence similarity: Human, Mouse, Rat
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-QINLRDDKWEVSKQ, from the Internal region of the protein sequence according to NP_001026879.1; NP_060833.1.
 Epitope    Internal region
 Note    This antibody is expected to recognize both reported isoforms (NP_001026879.1 and NP_060833.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-C10orf59 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-C10orf59 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-C10orf59 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 37kDa band observed in Mouse Kidney and Rat Kidney lysates (calculated MW of 37.8kDa according to Human NP_001026879.1 and 35. 0kDa according to Rat NP_001014189.1). Recommended concentration: 0.5-1.5ug/ml.
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 Western Blot (WB) of anti-C10orf59 antibody    (0.5ug/ml) staining of Rat Kidney lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-C10orf59 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for C10orf59. It may not necessarily be applicable to this product.
 NCBI GI #    72534708
 NCBI GeneID    55328
 NCBI Accession #    NP_001026879.1 [Other Products]
 NCBI Related Accession #    NP_060833.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001031709.1 [Other Products]
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 UniProt Secondary Accession #    Q9BS33; Q9NUP8 [Other Products]
 UniProt Related Accession #    Q5VYX0 [Other Products]
 Molecular Weight    34,949 Da
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 NCBI Official Full Name    renalase isoform 1
 NCBI Official Synonym Full Names    renalase, FAD-dependent amine oxidase
 NCBI Official Symbol    RNLS [Similar Products]
 NCBI Official Synonym Symbols   
C10orf59; RENALASE
[Similar Products]
 NCBI Protein Information    renalase
 UniProt Protein Name    Renalase
 UniProt Synonym Protein Names   
Monoamine oxidase-C; MAO-C
 Protein Family    Renalase
 UniProt Gene Name    RNLS [Similar Products]
 UniProt Synonym Gene Names    C10orf59; MAO-C [Similar Products]
 UniProt Entry Name    RNLS_HUMAN
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 NCBI Summary for C10orf59    Renalase is a flavin adenine dinucleotide-dependent amine oxidase that is secreted into the blood from the kidney (Xu et al., 2005 [PubMed 15841207]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for C10orf59    RENALASE: Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity. Belongs to the renalase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Secreted, signal peptide; Secreted; EC 1.6.3.5

Chromosomal Location of Human Ortholog: 10q23.31

Cellular Component: extracellular space

Molecular Function: oxidoreductase activity
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 Research Articles on C10orf59    1. the antihypertensive effect of renalase still remains a phenomenon with unclear biochemical mechanim(s) and functions of intracellular and extracellular (circulating) renalases obviously differ.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-C10orf59 antibodyOrgans/Tissues associated with anti-C10orf59 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3 publications with C10orf59 and Inflammation
 Cardiovascular Diseases Antibodies  >2 publications with C10orf59 and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >2 publications with C10orf59 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >2 publications with C10orf59 and Neoplasm Metastasis
 Hypertension Antibodies  >2 publications with C10orf59 and Hypertension
 Kidney Diseases Antibodies  >1 publications with C10orf59 and Kidney Diseases
 Disease Models, Animal Antibodies  >1 publications with C10orf59 and Disease Models, Animal
 Heart Diseases Antibodies  >1 publications with C10orf59 and Heart Diseases
 Memory Disorders Antibodies  >1 publications with C10orf59 and Memory Disorders
 Learning Disorders Antibodies  >1 publications with C10orf59 and Learning Disorders
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >2 publications with C10orf59 and Eye
 Kidney Antibodies  >2 publications with C10orf59 and Kidney
 Muscle Antibodies  >1 publications with C10orf59 and Muscle
 Brain Antibodies  >1 publications with C10orf59 and Brain
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