NP_001158213.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
rho GTPase-activating protein 4 isoform 1
NCBI Official Synonym Full Names
Rho GTPase activating protein 4
NCBI Official Synonym Symbols
C1; RGC1; p115; SrGAP4; RhoGAP4 [Similar Products]
NCBI Protein Information
rho GTPase-activating protein 4; Rho-GAP hematopoietic protein C1; rho-type GTPase-activating protein 4
UniProt Protein Name
Rho GTPase-activating protein 4
UniProt Synonym Protein Names
Rho-GAP hematopoietic protein C1; Rho-type GTPase-activating protein 4; p115
UniProt Synonym Gene Names
UniProt Entry Name
RHG04_HUMAN
NCBI Summary for ARHGAP4
This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
UniProt Comments for ARHGAP4
ARHGAP4: Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GAPs; GAPs, Rac/Rho
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: nucleoplasm; Golgi apparatus; microtubule; growth cone; focal adhesion; cytoplasm; cytosol
Molecular Function: protein binding; SH3/SH2 adaptor activity; Rac GTPase binding
Biological Process: regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of signal transduction; positive regulation of apoptosis; small GTPase mediated signal transduction; cytoskeleton organization and biogenesis; negative regulation of axon extension; negative regulation of cell migration; Rho protein signal transduction
Research Articles on ARHGAP4
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Products associated with anti-ARHGAP4 antibody
Pathways associated with anti-ARHGAP4 antibody
Diseases associated with anti-ARHGAP4 antibody
Organs/Tissues associated with anti-ARHGAP4 antibody
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