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anti-RPS6KA1 antibody :: Rabbit anti-Human, Mouse Rsk1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS622629 anti-RPS6KA1 antibody
Unit / Price
0.1 mg  /  $520 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Rsk1 (RPS6KA1), Polyclonal Antibody

 Also Known As   

Rsk1, phosphorylated (Ser352) (Ribosomal S6 Kinase 1, RSK-1, 90kD Ribosomal Protein S6 Kinase 1, p90RSK1, p90-RSK 1, p90S6K, MAP Kinase-activated Protein Kinase 1a, MAPK-activated Protein Kinase 1a, MAPKAP Kinase 1a, Mapkapk1a, MAPKAPK-1a, Ribosomal Prote

 Product Synonym Names    Anti -Rsk1, phosphorylated (Ser352) (Ribosomal S6 Kinase 1, RSK-1, 90kD Ribosomal Protein S6 Kinase 1, p90RSK1, p90-RSK 1, p90S6K, MAP Kinase-activated Protein Kinase 1a, MAPK-activated Protein Kinase 1a, MAPKAP Kinase 1a, Mapkapk1a, MAPKAPK-1a, Ribosomal Prote
 Product Gene Name   

anti-RPS6KA1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (26856249..26901520). Location: 1p
 OMIM    601684
 3D Structure    ModBase 3D Structure for Q15418
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    Recognizes endogenous levels of p90RSK only when phosphorylated at serine 352.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol.
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 Immunogen    Synthesized phosphopeptide derived from mouse p90RSK around the phosphorylation site of serine 352 (R-D-SP-P-G).
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 Preparation and Storage    For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-RPS6KA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RPS6KA1 antibody

   RSK1 (also called MAPK Activated Protein Kinase-1a; MAPKAP-K1a) is a member of the broadly expressed p90 Ribosomal S6 Kinase (RSK) family of serine/threonine kinases that also includes RSK2 (MAPKAP-K1b), RSK3 (MAPKAP-K1c), and RSK4. RSK proteins are substrates for and downstream transducers of MAPK signaling proteins, primarily ERK1&2. RSK proteins possess two separate kinase domains, the C-terminal kinase domain and the N-terminal kinase domain, separated by a linker region containing a hydrophobic motif. Activation of RSK1 is a multi-step process involving phosphorylation of multiple residues within the three domains, changes in RSK protein localization, and modulation of RSK complex formation with ERK1&2 and/or 14-3-3 beta proteins. RSK is activated by many stimuli including growth factors, phorbol esters, cAMP, heat shock, and irradiation. ERK 1&2 phosphorylates threonine 573 of the C-terminal kinase domain, thereby stimulating this kinase activity and leading to phosphorylation of serine 380 within the linker region. Phosphoserine 380 is part of a docking site for PDK1, a constitutively active cytoplasmic kinase that phosphorylates serine 221 and thereby activates the N-terminal kinase domain to phosphorylate various substrates that include transporters, transcription factors, and transcription co-activators.
 Product Categories/Family for anti-RPS6KA1 antibody    Antibodies; Abs to Protein Kinases, Ribosomal
 Applications Tested/Suitable for anti-RPS6KA1 antibody   

Western Blot (WB)

 Application Notes for anti-RPS6KA1 antibody    Suitable for use in Western Blot.
Dilution: Western Blot: 1:500-1:1,000
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NCBI/Uniprot data below describe general gene information for RPS6KA1. It may not necessarily be applicable to this product.
 NCBI GI #    55743134
 NCBI GeneID    6195
 NCBI Accession #    NP_001006666.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001006665.1 [Other Products]
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 UniProt Primary Accession #    Q15418 [Other Products]
 UniProt Secondary Accession #    Q5SVM5; Q5SVM8; Q5SVM9; Q96C05; Q9BQK2; A6NGG4; A8K9K7; B2RDY8; B7Z5J0 [Other Products]
 UniProt Related Accession #    Q15418 [Other Products]
 Molecular Weight    82,723 Da [Similar Products]
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 NCBI Official Full Name    ribosomal protein S6 kinase alpha-1 isoform b
 NCBI Official Synonym Full Names    ribosomal protein S6 kinase, 90kDa, polypeptide 1
 NCBI Official Symbol    RPS6KA1 [Similar Products]
 NCBI Official Synonym Symbols   
RSK; HU-1; RSK1; MAPKAPK1A
[Similar Products]
 NCBI Protein Information    ribosomal protein S6 kinase alpha-1; RSK-1; p90S6K; p90RSK1; p90-RSK 1; MAPKAPK-1a; S6K-alpha 1; S6K-alpha-1; MAPKAP kinase 1a; ribosomal S6 kinase 1; MAPK-activated protein kinase 1a; ribosomal protein S6 kinase alpha 1; 90 kDa ribosomal protein S6 kinase 1; MAP kinase-activated protein kinase 1a; dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)
 UniProt Protein Name    Ribosomal protein S6 kinase alpha-1
 UniProt Synonym Protein Names   
90 kDa ribosomal protein S6 kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; Ribosomal S6 kinase 1
 Protein Family    Ribosomal protein S6 kinase
 UniProt Gene Name    RPS6KA1 [Similar Products]
 UniProt Synonym Gene Names    MAPKAPK1A; RSK1; S6K-alpha-1; p90-RSK 1; p90RSK1; p90S6K; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; RSK-1 [Similar Products]
 UniProt Entry Name    KS6A1_HUMAN
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 NCBI Summary for RPS6KA1    This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RPS6KA1    p90RSK: an AGC kinase of the RSK family. Phosphorylated and activated by Erk1 and -2 in response to many growth factors, polypeptide hormones and neurotransmitters. Several phosphorylation sites are important for its activation. Possesses two kinase domains connected by a regulator linker region. Phosphorylates a wide range of substrates including ribosomal protein S6. Prominently expressed in brain structures essential for cognitive function and learning.

Protein type: Protein kinase, AGC; Translation; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; AGC group; RSK family; RSK subfamily

Chromosomal Location of Human Ortholog: 1p

Cellular Component: nucleoplasm; cytoplasm; spindle; cytosol; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; caspase inhibitor activity; magnesium ion binding; protein serine/threonine/tyrosine kinase activity; ATP binding

Biological Process: regulation of transcription in response to stress; axon guidance; nerve growth factor receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; regulation of translation in response to stress; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; negative regulation of caspase activity; signal transduction; cell cycle; positive regulation of cell growth; protein amino acid phosphorylation; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; synaptic transmission; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; positive regulation of cell differentiation; toll-like receptor 4 signaling pathway; negative regulation of apoptosis
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 Research Articles on RPS6KA1    1. results indicate that RSK directly phosphorylates Gab2 on 3 serine residues; findings show RSK-mediated Gab2 phosphorylation inhibits Shp2 recruitment, suggesting RSK mediates a negative-feedback loop that attenuates Gab2-dependent functions including cell motility
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RPS6KA1 antibodyPathways associated with anti-RPS6KA1 antibody
 Reference Product  PubMed Publications
 MAPK1 antibody  >29 publications with RPS6KA1 and MAPK1
 MAPK3 antibody  >27 publications with RPS6KA1 and MAPK3
 RPS6 antibody  >6 publications with RPS6KA1 and RPS6
 TSC2 antibody  >6 publications with RPS6KA1 and TSC2
 EIF4B antibody  >5 publications with RPS6KA1 and EIF4B
 TSC1 antibody  >4 publications with RPS6KA1 and TSC1
 CREB1 antibody  >3 publications with RPS6KA1 and CREB1
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CREB Phosphorylation Pathway antibodies  CREB Phosphorylation Pathway Diagram
 CREB Phosphorylation Through The Activation Of Ras Pathway antibodies  CREB Phosphorylation Through The Activation Of Ras Pathway Diagram
 Cytoplasmic Ribosomal Proteins Pathway antibodies  Cytoplasmic Ribosomal Proteins Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
Diseases associated with anti-RPS6KA1 antibodyOrgans/Tissues associated with anti-RPS6KA1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >33 publications with RPS6KA1 and Neoplasms
 Inflammation Antibodies  >13 publications with RPS6KA1 and Inflammation
 Hypertrophy Antibodies  >11 publications with RPS6KA1 and Hypertrophy
 Disease Models, Animal Antibodies  >10 publications with RPS6KA1 and Disease Models, Animal
 Liver Diseases Antibodies  >10 publications with RPS6KA1 and Liver Diseases
 Cardiovascular Diseases Antibodies  >7 publications with RPS6KA1 and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >7 publications with RPS6KA1 and Breast Neoplasms
 Hyperplasia Antibodies  >6 publications with RPS6KA1 and Hyperplasia
 Adenocarcinoma Antibodies  >5 publications with RPS6KA1 and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >5 publications with RPS6KA1 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >45 publications with RPS6KA1 and Muscle
 Blood Antibodies  >26 publications with RPS6KA1 and Blood
 Brain Antibodies  >24 publications with RPS6KA1 and Brain
 Liver Antibodies  >23 publications with RPS6KA1 and Liver
 Heart Antibodies  >19 publications with RPS6KA1 and Heart
 Lung Antibodies  >8 publications with RPS6KA1 and Lung
 Connective Tissue Antibodies  >7 publications with RPS6KA1 and Connective Tissue
 Vascular Antibodies  >7 publications with RPS6KA1 and Vascular
 Embryonic Tissue Antibodies  >5 publications with RPS6KA1 and Embryonic Tissue
 Bone Antibodies  >5 publications with RPS6KA1 and Bone
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