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anti-RYR1 antibody :: Rabbit anti-Human Ryanodine receptor 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1489726
Immunofluorescence (IF)
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ryanodine receptor 1 (RYR1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Ryanodine receptor 1 polyclonal Antibody

 Product Synonym Names    Skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; Skeletal muscle-type ryanodine receptor; Type 1 ryanodine receptor; RYDR
 Product Gene Name   

anti-RYR1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    117000
 3D Structure    ModBase 3D Structure for P21817
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Ryanodine receptor 1 protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-34016 / sc-34019 / sc-8170 / sc-8169 / sc-13942
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-RYR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RYR1 antibody

   Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca2+ leaking into the cytoplasm. Can also mediate the release of Ca2+ from intracellular stores in neurons, and may thereby promote prolonged Ca2+ signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis
 Applications Tested/Suitable for anti-RYR1 antibody   

ELISA (EIA), Immunofluorescence (IF)

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 Immunofluorescence (IF) of anti-RYR1 antibody    Immunofluorescent analysis of HepG2 cells using MBS1489726 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-RYR1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for RYR1. It may not necessarily be applicable to this product.
 NCBI GI #    113204615
 NCBI GeneID    6261
 NCBI Accession #    NP_000531.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000540.2 [Other Products]
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 UniProt Primary Accession #    P21817 [Other Products]
 UniProt Secondary Accession #    Q16314; Q16368; Q9NPK1; Q9P1U4 [Other Products]
 UniProt Related Accession #    P21817 [Other Products]
 Molecular Weight    564,550 Da
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 NCBI Official Full Name    ryanodine receptor 1 isoform 1
 NCBI Official Synonym Full Names    ryanodine receptor 1
 NCBI Official Symbol    RYR1 [Similar Products]
 NCBI Official Synonym Symbols   
CCO; MHS; RYR; MHS1; RYDR; SKRR; RYR-1; PPP1R137
[Similar Products]
 NCBI Protein Information    ryanodine receptor 1
 UniProt Protein Name    Ryanodine receptor 1
 UniProt Synonym Protein Names   
Skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; Skeletal muscle-type ryanodine receptor; Type 1 ryanodine receptor
 Protein Family    Ryanodine receptor
 UniProt Gene Name    RYR1 [Similar Products]
 UniProt Synonym Gene Names    RYDR; RYR-1; RyR1 [Similar Products]
 UniProt Entry Name    RYR1_HUMAN
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 NCBI Summary for RYR1    This gene encodes a ryanodine receptor found in skeletal muscle. The encoded protein functions as a calcium release channel in the sarcoplasmic reticulum but also serves to connect the sarcoplasmic reticulum and transverse tubule. Mutations in this gene are associated with malignant hyperthermia susceptibility, central core disease, and minicore myopathy with external ophthalmoplegia. Alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RYR1    RYR1: Calcium channel that controls communication between transverse-tubules and sarcoplasmic reticulum. Contraction of skeletal muscle is triggered by release of calcium ions from SR following depolarization of T-tubules. Can mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal development of muscle fibers, skeletal muscle, heart morphogenesis, and skin development and ossification during embryogenesis. Defects in RYR1 are the cause of malignant hyperthermia susceptibility type 1 (MHS1) and central core disease of muscle (CCD). CCD is an autosomal dominant congenital myopathy, but a severe autosomal recessive form also exists. Defects in RYR1 are the cause of multiminicore disease with external ophthalmoplegia (MMDO), congenital myopathy with fiber-type disproportion (CFTD). Defects in RYR1 may be a cause of Samaritan myopathy, a congenital myopathy with benign course. Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, ion channel; Channel, calcium

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: cell cortex; cytoplasm; cytosol; I band; integral to plasma membrane; junctional membrane complex; plasma membrane; sarcoplasmic reticulum; sarcoplasmic reticulum membrane; smooth endoplasmic reticulum; T-tubule

Molecular Function: calcium channel activity; calcium ion binding; calcium-release channel activity; calmodulin binding; protease binding; protein binding; ryanodine-sensitive calcium-release channel activity; voltage-gated calcium channel activity

Biological Process: calcium ion transport; cytosolic calcium ion homeostasis; muscle contraction; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; release of sequestered calcium ion into cytosol; response to caffeine; response to hypoxia; skeletal muscle fiber development; skin development; transmembrane transport

Disease: Central Core Disease Of Muscle; Malignant Hyperthermia, Susceptibility To, 1; Minicore Myopathy With External Ophthalmoplegia; Myopathy, Congenital, With Fiber-type Disproportion
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 Research Articles on RYR1    1. investigated spectrum of RYR-1 related disorders in a retrospective cohort study. 61 different mutations were detected, of which 24 were novel. Some mutations are present in both dominant (MHS) and recessive modes (congenital myopathy) of inheritance
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RYR1 antibodyPathways associated with anti-RYR1 antibody
 Reference Product  PubMed Publications
 CACNA1S antibody  >50 publications with RYR1 and CACNA1S
 TRDN antibody  >42 publications with RYR1 and TRDN
 ASPH antibody  >23 publications with RYR1 and ASPH
 FKBP1B antibody  >5 publications with RYR1 and FKBP1B
 HOMER1 antibody  >4 publications with RYR1 and HOMER1
 HOMER3 antibody  >1 publications with RYR1 and HOMER3
 Products by Pathway  Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Cardiac Conduction Pathway antibodies  Cardiac Conduction Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Ion Homeostasis Pathway antibodies  Ion Homeostasis Pathway Diagram
 Long-term Depression Pathway antibodies  Long-term Depression Pathway Diagram
 Long-term Depression Pathway antibodies  Long-term Depression Pathway Diagram
Diseases associated with anti-RYR1 antibodyOrgans/Tissues associated with anti-RYR1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >966 publications with RYR1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >943 publications with RYR1 and Heart Diseases
 Malignant Hyperthermia Antibodies  >596 publications with RYR1 and Malignant Hyperthermia
 Death Antibodies  >375 publications with RYR1 and Death
 Disease Models, Animal Antibodies  >247 publications with RYR1 and Disease Models, Animal
 Myopathies, Structural, Congenital Antibodies  >160 publications with RYR1 and Myopathies, Structural, Congenital
 Myopathy, Central Core Antibodies  >153 publications with RYR1 and Myopathy, Central Core
 Congenital Abnormalities Antibodies  >86 publications with RYR1 and Congenital Abnormalities
 Hypertension Antibodies  >69 publications with RYR1 and Hypertension
 Malignant hyperthermia susceptibility type 1 Antibodies  >62 publications with RYR1 and Malignant hyperthermia susceptibility type 1
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >4262 publications with RYR1 and Muscle
 Brain Antibodies  >606 publications with RYR1 and Brain
 Lung Antibodies  >138 publications with RYR1 and Lung
 Embryonic Tissue Antibodies  >129 publications with RYR1 and Embryonic Tissue
 Kidney Antibodies  >99 publications with RYR1 and Kidney
 Pancreas Antibodies  >85 publications with RYR1 and Pancreas
 Eye Antibodies  >52 publications with RYR1 and Eye
 Ganglia Antibodies  >50 publications with RYR1 and Ganglia
 Intestine Antibodies  >45 publications with RYR1 and Intestine
 Bone Antibodies  >31 publications with RYR1 and Bone
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