NP_006262.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,546 Da
NCBI Official Full Name
protein S100-A1
NCBI Official Synonym Full Names
S100 calcium binding protein A1
NCBI Protein Information
protein S100-A1
UniProt Protein Name
Protein S100-A1
UniProt Synonym Protein Names
S-100 protein alpha chain; S-100 protein subunit alpha; S100 calcium-binding protein A1
UniProt Synonym Gene Names
NCBI Summary for S-100 alpha
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]
UniProt Comments for S-100 alpha
Probably acts as a Ca2+ signal transducer (PubMed:22399290). In response to an increase in intracellular Ca2+ levels, binds calcium which triggers a conformational change (PubMed:23351007). This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity (PubMed:22399290).
Research Articles on S-100 alpha
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Products associated with anti-S-100 alpha antibody
Diseases associated with anti-S-100 alpha antibody
Organs/Tissues associated with anti-S-100 alpha antibody
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