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anti-S100B / S100 Beta antibody :: Rabbit anti-Mouse, Human S100B / S100 Beta Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS249602
Unit / Price
0.2 mL  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

S100B / S100 Beta, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-S100B / S100 Beta Antibody IHC-plus

 Product Synonym Names    Rabbit Polyclonal to Human S100B / S100 Beta; Human S100B / S100 Beta; NEF; Protein S100-B; S100; S100 calcium binding protein B; S100 calcium-binding protein B; S100beta; S-100 protein beta chain; S-100 protein subunit beta; S100-B
 Product Gene Name   

anti-S100B / S100 Beta antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    176990
 3D Structure    ModBase 3D Structure for P04271
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Mouse, Human
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 Specificity    Human S100B / S100
 Purity/Purification    Immunoaffinity purified
 Form/Format    PBS, 0.09% sodium azide
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 Immunogen    S100B / S100 Beta antibody was raised against s100B recombinant protein.
 Immunogen Description    S100B recombinant protein.
 Immunogen Type    Recombinant protein
 Target Species    Human
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months.
For long term storage store at -20 degree C.
 Other Notes    Small volumes of anti-S100B / S100 Beta antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-S100B / S100 Beta antibody

   S100B Antibody, NEF Antibody, Protein S100-B Antibody, S100 Antibody, S100 calcium binding protein B Antibody, S100 calcium-binding protein B Antibody, S100beta Antibody, S-100 protein beta chain Antibody, S-100 protein subunit beta Antibody, S100-B Antibody Description: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3.
 Applications Tested/Suitable for anti-S100B / S100 Beta antibody   

Immunohistochemistry (IHC) Paraffin, Western Blot (WB), Flow Cytometry (FC/FACS)

 Application Notes for anti-S100B / S100 Beta antibody    Flow Cytometry (1:10 - 1:50)
IHC-P (5 ug/ml)
WB (1:1000)
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 Immunohistochemistry (IHC) of anti-S100B / S100 Beta antibody    Anti-S100B / S100 antibody IHC staining of human nerve. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-S100B / S100 Beta antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-S100B / S100 Beta antibody    Western blot of lysates from A431 cell line, mouse brain, rat brain tissue (from left to right), using S100B Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.
anti-S100B / S100 Beta antibody Western Blot (WB) (WB) image
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 Flow Cytometry (FC/FACS) of anti-S100B / S100 Beta antibody    S100B Antibody flow cytometry of A375 cells (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-S100B / S100 Beta antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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NCBI/Uniprot data below describe general gene information for S100B / S100 Beta. It may not necessarily be applicable to this product.
 NCBI GI #    5454034
 NCBI GeneID    6285
 NCBI Accession #    NP_006263.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006272.2 [Other Products]
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 UniProt Primary Accession #    P04271 [Other Products]
 UniProt Secondary Accession #    D3DSN6 [Other Products]
 UniProt Related Accession #    P04271 [Other Products]
 Molecular Weight    10,713 Da
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 NCBI Official Full Name    protein S100-B
 NCBI Official Synonym Full Names    S100 calcium binding protein B
 NCBI Official Symbol    S100B [Similar Products]
 NCBI Official Synonym Symbols   
NEF; S100; S100-B; S100beta
[Similar Products]
 NCBI Protein Information    protein S100-B
 UniProt Protein Name    Protein S100-B
 UniProt Synonym Protein Names   
S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B
 UniProt Gene Name    S100B [Similar Products]
 UniProt Entry Name    S100B_HUMAN
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 NCBI Summary for S100B / S100 Beta    The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008]
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 UniProt Comments for S100B / S100 Beta    S100B: Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. The S100B dimer binds two molecules of STK38. Interacts with AGER. The S100B dimer interacts with two molecules of CAPZA1. Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues. Belongs to the S-101 family.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: cell soma; cytoplasm; extracellular region; extracellular space; intracellular membrane-bound organelle; nucleus; perinuclear region of cytoplasm; ruffle

Molecular Function: calcium ion binding; calcium-dependent protein binding; identical protein binding; protein binding; protein homodimerization activity; RAGE receptor binding; tau protein binding; zinc ion binding

Biological Process: astrocyte differentiation; axonogenesis; cell proliferation; central nervous system development; innate immune response; learning and/or memory; memory; positive regulation of apoptosis; positive regulation of cell proliferation; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of cell shape; regulation of neuronal synaptic plasticity; response to glucocorticoid stimulus; response to methylmercury
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 Research Articles on S100B / S100 Beta    1. The mean serum S-100B protein level of the breath-holding spells group was 56.38 +/- 13.26 pg/mL, and of the control group, 48.53 +/- 16.77 pg/mL.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-S100B / S100 Beta antibodyPathways associated with anti-S100B / S100 Beta antibody
 Reference Product  PubMed Publications
 GFAP antibody  >185 publications with S100B / S100 Beta and GFAP
 S100A1 antibody  >93 publications with S100B / S100 Beta and S100A1
 HMGB1 antibody  >27 publications with S100B / S100 Beta and HMGB1
 FGF2 antibody  >9 publications with S100B / S100 Beta and FGF2
 TP53 antibody  >5 publications with S100B / S100 Beta and TP53
 AHNAK antibody  >3 publications with S100B / S100 Beta and AHNAK
 IQGAP1 antibody  >3 publications with S100B / S100 Beta and IQGAP1
 AGER antibody  >3 publications with S100B / S100 Beta and AGER
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 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 MyD88 Cascade Initiated On Plasma Membrane Pathway antibodies  MyD88 Cascade Initiated On Plasma Membrane Pathway Diagram
 MyD88 Dependent Cascade Initiated On Endosome Pathway antibodies  MyD88 Dependent Cascade Initiated On Endosome Pathway Diagram
 MyD88-independent TLR3/TLR4 Cascade Pathway antibodies  MyD88-independent TLR3/TLR4 Cascade Pathway Diagram
 MyD88:Mal Cascade Initiated On Plasma Membrane Pathway antibodies  MyD88:Mal Cascade Initiated On Plasma Membrane Pathway Diagram
Diseases associated with anti-S100B / S100 Beta antibodyOrgans/Tissues associated with anti-S100B / S100 Beta antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >719 publications with S100B / S100 Beta and Nervous System Diseases
 Brain Diseases Antibodies  >596 publications with S100B / S100 Beta and Brain Diseases
 Cardiovascular Diseases Antibodies  >262 publications with S100B / S100 Beta and Cardiovascular Diseases
 Brain Injuries Antibodies  >219 publications with S100B / S100 Beta and Brain Injuries
 Inflammation Antibodies  >160 publications with S100B / S100 Beta and Inflammation
 Disease Models, Animal Antibodies  >127 publications with S100B / S100 Beta and Disease Models, Animal
 Hemorrhage Antibodies  >87 publications with S100B / S100 Beta and Hemorrhage
 Heart Diseases Antibodies  >77 publications with S100B / S100 Beta and Heart Diseases
 Necrosis Antibodies  >67 publications with S100B / S100 Beta and Necrosis
 Cognition Disorders Antibodies  >51 publications with S100B / S100 Beta and Cognition Disorders
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >1047 publications with S100B / S100 Beta and Nerve
 Brain Antibodies  >1025 publications with S100B / S100 Beta and Brain
 Blood Antibodies  >829 publications with S100B / S100 Beta and Blood
 Heart Antibodies  >129 publications with S100B / S100 Beta and Heart
 Skin Antibodies  >67 publications with S100B / S100 Beta and Skin
 Eye Antibodies  >37 publications with S100B / S100 Beta and Eye
 Lung Antibodies  >36 publications with S100B / S100 Beta and Lung
 Spinal Cord Antibodies  >31 publications with S100B / S100 Beta and Spinal Cord
 Embryonic Tissue Antibodies  >17 publications with S100B / S100 Beta and Embryonic Tissue
 Adipose Tissue Antibodies  >12 publications with S100B / S100 Beta and Adipose Tissue
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