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anti-S1PR1 antibody :: Rabbit anti-Human S1PR1 / EDG1 / S1P1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240198
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

S1PR1 / EDG1 / S1P1, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit Polyclonal to Human S1PR1 / EDG1 / S1P1

 Product Synonym Names    Anti-S1PR1 / EDG1 / S1P1 Antibody (aa25-40) IHC-plus; S1PR1; CD363; CD363 antigen; CHEDG1; ECGF1; EDG-1; D1S3362; EDG1; S1P1; S1P receptor Edg-1; S1P receptor 1; Human S1PR1; EDG1; S1P1
 Product Gene Name   

anti-S1PR1 antibody

[Similar Products]
 Product Synonym Gene Name    EDG1; S1P1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601974
 3D Structure    ModBase 3D Structure for P21453
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Peptide corresponding to amino acids 25-40 of human Edg1.
 Purity/Purification    Protein G Purified
 Form/Format    PBS, 0.09% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human S1PR1 / EDG1.
 Immunogen Type    Synthetic peptide
 Immunogen    S1PR1 / EDG1 / S1P1 antibody was raised against synthetic peptide from human S1PR1 / EDG1.
 Antigen Modification    aa25-40
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
 Other Notes    Small volumes of anti-S1PR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-S1PR1 antibody

   EDG1, a Lysophospholipid/Lysosphingolipid Receptor, binds sphingosine-1-phosphate and may control cell proliferation, survival, and suppression of apoptosis. Overexpression of EDG-1 leads to increased cell-cell aggregation and overexpression of cadherins.
 Product Categories/Family for anti-S1PR1 antibody    Family: GPCR
Subfamily: Lysophospholipid/Lysosphingolipid
 Applications Tested/Suitable for anti-S1PR1 antibody   

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

 Application Notes for anti-S1PR1 antibody    ELISA (1:000 - 1:1000), IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibo...
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 Immunohistochemistry (IHC) of anti-S1PR1 antibody    Anti-S1PR1 / EDG1 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-S1PR1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for S1PR1. It may not necessarily be applicable to this product.
 NCBI GI #    13027636
 NCBI GeneID    1901
 NCBI Accession #    NP_001391.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001400.4 [Other Products]
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 UniProt Primary Accession #    P21453 [Other Products]
 UniProt Secondary Accession #    Q9BYY4; Q9NYN8; D3DT66 [Other Products]
 UniProt Related Accession #    P21453 [Other Products]
 Molecular Weight    42,811 Da
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 NCBI Official Full Name    sphingosine 1-phosphate receptor 1
 NCBI Official Synonym Full Names    sphingosine-1-phosphate receptor 1
 NCBI Official Symbol    S1PR1 [Similar Products]
 NCBI Official Synonym Symbols   
EDG1; S1P1; CD363; ECGF1; EDG-1; CHEDG1; D1S3362
[Similar Products]
 NCBI Protein Information    sphingosine 1-phosphate receptor 1; S1P receptor 1; S1P receptor Edg-1; sphingosine 1-phosphate receptor EDG1; sphingosine 1-phosphate receptor Edg-1; endothelial differentiation G-protein coupled receptor 1; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1
 UniProt Protein Name    Sphingosine 1-phosphate receptor 1
 UniProt Synonym Protein Names   
Endothelial differentiation G-protein coupled receptor 1; Sphingosine 1-phosphate receptor Edg-1; S1P receptor Edg-1; CD_antigen: CD363
 Protein Family    Sphingosine 1-phosphate receptor
 UniProt Gene Name    S1PR1 [Similar Products]
 UniProt Synonym Gene Names    CHEDG1; EDG1; S1P receptor 1; S1P1; S1P receptor Edg-1 [Similar Products]
 UniProt Entry Name    S1PR1_HUMAN
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 NCBI Summary for S1PR1    The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. [provided by RefSeq, Jul 2008]
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 UniProt Comments for S1PR1    EDG-1: a G protein-coupled receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Highly expressed in endothelial cells and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin. Suggested to be involved in the processes that regulate the migration/differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. S1P-induced endothelial cell migration requires AKT1-mediated phosphorylation of the third intracellular loop. Seems to be coupled to the G(i) subclass of heteromeric G proteins.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p21

Cellular Component: integral to membrane; plasma membrane; intrinsic to plasma membrane; endosome; lipid raft; external side of plasma membrane

Molecular Function: G-protein coupled receptor activity; sphingolipid binding; G-protein-coupled receptor binding

Biological Process: regulation of cell adhesion; lamellipodium biogenesis; endothelial cell differentiation; cell migration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of bone resorption; negative regulation of stress fiber formation; positive regulation of positive chemotaxis; positive regulation of smooth muscle cell proliferation; transmission of nerve impulse; chemotaxis; blood vessel maturation; neuron differentiation; G-protein coupled receptor protein signaling pathway; actin cytoskeleton reorganization; positive regulation of transcription from RNA polymerase II promoter; G-protein signaling, adenylate cyclase inhibiting pathway; brain development; angiogenesis; cell adhesion; regulation of bone mineralization; positive regulation of cell migration
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 Research Articles on S1PR1    1. Data show that sphingosine kinase SphK1 and sphingosine-1-phosphate (S1P) receptors S1P1, S1P2, S1P3, and S1P5 were expressed from primary, up to recurrent and secondary glioblastomas, with sphingosine kinase SphK2 levels were highest in primary tumors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-S1PR1 antibody
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 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Lysosphingolipid And LPA Receptors Pathway antibodies  Lysosphingolipid And LPA Receptors Pathway Diagram
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