Q9UJQ4.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Sal-like protein 4
NCBI Official Synonym Full Names
spalt-like transcription factor 4
NCBI Official Synonym Symbols
DRRS; HSAL4; ZNF797; dJ1112F19.1 [Similar Products]
NCBI Protein Information
sal-like protein 4; zinc finger protein 797; zinc finger protein SALL4
UniProt Protein Name
Sal-like protein 4
UniProt Synonym Protein Names
Zinc finger protein 797; Zinc finger protein SALL4
UniProt Synonym Gene Names
UniProt Entry Name
SALL4_HUMAN
NCBI Summary for SALL4
The protein encoded by this gene may be a zinc finger transcription factor. Defects in this gene are a cause of Duane-radial ray syndrome (DRRS). [provided by RefSeq, Jul 2008]
UniProt Comments for SALL4
SALL4: a transcription factor and oncofetal protein expressed embryonically and in the testis. Plays a key role in maintenance and self-renewal of embryonic stem cells. Interacts with NANOG and OCT4. Ectopically expressed in acute B-cell lymphoblastic leukemia (B-ALL) and myeloid leukemia (AML), playing a role in the survival of B-ALL cells and in myeloid leukemogenesis. Aberrantly expressed in multiple carcinomas including human gastric carcinoma and hepatocellular carcinoma. Maintains the stem cell qualities of EpCAM-positive hepatocellular carcinoma cells. Expressed in primary human endometrial cancer samples but not normal or hyperplastic endometrial cells. Its expression in carcinomas positively correlates with metastatic potential and poor patient survival. Specifically binds the c-Myc promoter region in endometrial cancer cells, apparently increasing c-Myc expression. Belongs to the sal C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: C2H2-type zinc finger protein; DNA-binding; Cancer Testis Antigen (CTA)
Chromosomal Location of Human Ortholog: 20q13.2
Cellular Component: nucleoplasm; heterochromatin; protein complex; intracellular membrane-bound organelle; cytoplasm
Molecular Function: DNA binding; metal ion binding
Biological Process: transcription, DNA-dependent; somatic stem cell maintenance; neural tube closure; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; inner cell mass cell proliferation; embryonic limb morphogenesis
Disease: Ivic Syndrome; Duane-radial Ray Syndrome
Research Articles on SALL4
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Products associated with anti-SALL4 antibody
Pathways associated with anti-SALL4 antibody
Diseases associated with anti-SALL4 antibody
Organs/Tissues associated with anti-SALL4 antibody
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