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anti-DLGAP2 antibody :: Rabbit SAPAP2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151501
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SAPAP2 (DLGAP2), Polyclonal Antibody

★Popular Item★
 Also Known As   

SAPAP2 Antibody

 Product Synonym Names    SAPAP2; DAP2; SAPAP2; DAP2; Disks large-associated protein 2; DAP-2; discs, large (Drosophila) homolog-associated protein 2
 Product Gene Name   

anti-DLGAP2 antibody

[Similar Products]
 Antibody/Peptide Pairs    SAPAP2 peptide (MBS152850) is used for blocking the activity of SAPAP2 antibody (MBS151501)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605438
 3D Structure    ModBase 3D Structure for Q9P1A6
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    At least three isoforms of SAPAP2 are known to exist. This SAPAP2 antibody will not cross-react with other SAPAP proteins.
 Purity/Purification    SAPAP2 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    SAPAP2 antibody was raised against a 16 amino acid synthetic peptide from near the center of human SAPAP2.

The immunogen is located within amino acids 480-530 of SAPAP2
 Buffer    SAPAP2 Antibody is supplied in PBS containing 0.02% sodium azide.
 Positive control    MBS151628- Raji Cell Lysate
MBS154323- Human Brain Tissue Slide
 Predicted MW    Predicted :43 kDa
Observed: 52 kDa
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 Preparation and Storage    SAPAP2 antibody can be stored at 4C for three months and -20C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-DLGAP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-DLGAP2 antibody

   SAPAP2 Antibody: SAP90/PSD-95-associated protein 2 (SAPAP2, also known as DLGAP2) is a member of a protein family whose members specifically interact with PSD-95/SAP90, a membrane-associated guanylate kinase localized at postsynaptic density (PSD) in neuronal cells. Like the other SAPAP proteins, SAPAP2 is thought to be an adaptor protein that also interacts with different synaptic scaffolding proteins, cytoskeletal and signaling components, such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). SAPAP2 mRNA is targeted to cell bodies in a similar manner to SAPAP1 and -4, whereas SAPAP3 mRNA is detected mainly in cell bodies.
 Applications Tested/Suitable for anti-DLGAP2 antibody   

ELISA, IF, IHC-P, WB

 Application Notes for anti-DLGAP2 antibody    SAPAP2 antibody can be used for detection of SAPAP2 by Western blot at 0.5-1 ug/mL .

Antibody can also be used for immunohistochemistry starting at 5 ug/mL.

For immunofluorescence start at 20 ug/mL.

Optimal dilutions for each application to be determined by the researcher.
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 Western Blot (WB) of anti-DLGAP2 antibody    Western blot analysis of SAPAP2 in L1210 cell lysate with SAPAP2 antibody at (A) 0.5 and (B) 1 μg/mL.
anti-DLGAP2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-DLGAP2 antibody    Immunohistochemistry of SAPAP2 in human brain with SAPAP2 antibody at 5 μg/mL.
anti-DLGAP2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-DLGAP2 antibody    Immunofluorescence of SAPAP2 in Human Brain cells with SAPAP2 antibody at 20 μg/mL.
anti-DLGAP2 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for DLGAP2. It may not necessarily be applicable to this product.
 NCBI GI #    160395585
 NCBI GeneID    9228
 NCBI Accession #    Q9P1A6.4 [Other Products]
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 UniProt Primary Accession #    Q9P1A6 [Other Products]
 UniProt Secondary Accession #    O14488; O14664; Q9P1A7; A1QCF8; A1QCF9; A5D8Y2 [Other Products]
 UniProt Related Accession #    Q9P1A6 [Other Products]
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 NCBI Official Full Name    Disks large-associated protein 2
 NCBI Official Synonym Full Names    discs, large (Drosophila) homolog-associated protein 2
 NCBI Official Symbol    DLGAP2 [Similar Products]
 NCBI Official Synonym Symbols   
DAP2; SAPAP2
[Similar Products]
 NCBI Protein Information    disks large-associated protein 2; PSD-95/SAP90-binding protein 2; discs large-associated protein 2; SAP90/PSD-95-associated protein 2
 UniProt Protein Name    Disks large-associated protein 2
 UniProt Synonym Protein Names   
PSD-95/SAP90-binding protein 2; SAP90/PSD-95-associated protein 2; SAPAP2
 Protein Family    Disks large-associated protein
 UniProt Gene Name    DLGAP2 [Similar Products]
 UniProt Synonym Gene Names    DAP2; DAP-2; SAPAP2 [Similar Products]
 UniProt Entry Name    DLGP2_HUMAN
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 NCBI Summary for DLGAP2    The product of this gene is a membrane-associated protein that may play a role in synapse organization and signalling in neuronal cells. This gene is biallelically expressed in the brain, however, only the paternal allele is expressed in the testis (PMID:18055845). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2014]
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 UniProt Comments for DLGAP2    SAPAP2: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. Belongs to the SAPAP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, other

Chromosomal Location of Human Ortholog: 8p23

Cellular Component: postsynaptic membrane; postsynaptic density; neurofilament; cell junction

Molecular Function: protein binding

Biological Process: nerve-nerve synaptic transmission
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 Research Articles on DLGAP2    1. DLGAP2 is a susceptible gene of schizophrenia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-DLGAP2 antibodyDiseases associated with anti-DLGAP2 antibody
 Reference Product  PubMed Publications
 SYNGAP1 antibody  >1 publications with DLGAP2 and SYNGAP1
 SHANK2 antibody  >1 publications with DLGAP2 and SHANK2
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >2 publications with DLGAP2 and Disease Models, Animal
 Learning Disorders Antibodies  >2 publications with DLGAP2 and Learning Disorders
 Diabetes Mellitus Antibodies  >1 publications with DLGAP2 and Diabetes Mellitus
 Cognition Disorders Antibodies  >1 publications with DLGAP2 and Cognition Disorders
 Diabetes Mellitus, Type 2 Antibodies  >1 publications with DLGAP2 and Diabetes Mellitus, Type 2
 Autistic Disorder Antibodies  >1 publications with DLGAP2 and Autistic Disorder
Organs/Tissues associated with anti-DLGAP2 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7 publications with DLGAP2 and Brain
 Blood Antibodies  >1 publications with DLGAP2 and Blood
 Testis Antibodies  >1 publications with DLGAP2 and Testis
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