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anti-SART1 antibody :: Rabbit SART1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9129672
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SART1, Polyclonal Antibody

 Also Known As   

SART1 Polyclonal Antibody

 Product Synonym Names    Ara1; HOMS1; Snu66; SART1259; SNRNP110
 Product Gene Name   

anti-SART1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605941
 3D Structure    ModBase 3D Structure for O43290
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity purification
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 Immunogen    Recombinant protein of human SART1
 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.   
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-SART1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SART1 antibody

   This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.
 Product Categories/Family for anti-SART1 antibody    Polyclonal
 Applications Tested/Suitable for anti-SART1 antibody   

Western Blot (WB)

 Application Notes for anti-SART1 antibody    WB: 1:500 - 1:2000
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 Western Blot (WB) of anti-SART1 antibody    Western blot analysis of extracts of various cell lines, using SART1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 10s.
anti-SART1 antibody Western Blot (WB) (WB) image
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 Immunoprecipitation (IP) of anti-SART1 antibody    Immunoprecipitation analysis of 150ug extracts of Jurkat cells using 3ug SART1 antibody. Western blot was performed from the immunoprecipitate using SART1 antibody at a dilition of 1:1000.
anti-SART1 antibody Immunoprecipitation (IP) (IP) image
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NCBI/Uniprot data below describe general gene information for SART1. It may not necessarily be applicable to this product.
 NCBI GI #    10863889
 NCBI GeneID    9092
 NCBI Accession #    NP_005137.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005146.4 [Other Products]
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 UniProt Primary Accession #    O43290 [Other Products]
 UniProt Secondary Accession #    Q53GB5; A6NDN1 [Other Products]
 UniProt Related Accession #    O43290 [Other Products]
 Molecular Weight    Calculated MW: 90kDa
Molecular Weight: 900
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 NCBI Official Full Name    U4/U6.U5 tri-snRNP-associated protein 1
 NCBI Official Synonym Full Names    squamous cell carcinoma antigen recognized by T-cells 1
 NCBI Official Symbol    SART1 [Similar Products]
 NCBI Official Synonym Symbols   
Ara1; HOMS1; Snu66; SART1259; SNRNP110
[Similar Products]
 NCBI Protein Information    U4/U6.U5 tri-snRNP-associated protein 1
 UniProt Protein Name    U4/U6.U5 tri-snRNP-associated protein 1
 UniProt Synonym Protein Names   
SNU66 homolog; hSnu66; Squamous cell carcinoma antigen recognized by T-cells 1; SART-1; hSART-1; U4/U6.U5 tri-snRNP-associated 110 kDa protein; Allergen: Hom s 1
 Protein Family    U4/U6.U5 tri-snRNP-associated protein
 UniProt Gene Name    SART1 [Similar Products]
 UniProt Synonym Gene Names    hSnu66; SART-1; hSART-1 [Similar Products]
 UniProt Entry Name    SNUT1_HUMAN
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 NCBI Summary for SART1    This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SART1    SART1: May play a role in mRNA splicing. May also bind to DNA. Belongs to the SNU66/SART1 family. 1 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA processing; RNA splicing; Apoptosis; RNA-binding; Spliceosome

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: Cajal body; cytoplasm; cytosol; Golgi apparatus; nucleoplasm; U4/U6 x U5 tri-snRNP complex

Molecular Function: protein binding

Biological Process: cell cycle arrest; gene expression; maturation of 5S rRNA; nuclear mRNA cis splicing, via U2-type spliceosome; nuclear mRNA splicing, via spliceosome; positive regulation of cytotoxic T cell differentiation; RNA splicing; spliceosomal snRNP biogenesis
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 Research Articles on SART1    1. SART1 exerts its anti-Hepatitis C virus action through direct transcriptional regulation for some Interferon stimulating genes and alternative splicing for others.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-SART1 antibodyDiseases associated with anti-SART1 antibody
 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies  Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome, U4/U6.U5 Tri-snRNP Pathway antibodies  Spliceosome, U4/U6.U5 Tri-snRNP Pathway Diagram
 Spliceosome, U4/U6.U5 Tri-snRNP Pathway antibodies  Spliceosome, U4/U6.U5 Tri-snRNP Pathway Diagram
 MRNA Splicing Pathway antibodies  MRNA Splicing Pathway Diagram
 MRNA Splicing - Major Pathway antibodies  MRNA Splicing - Major Pathway Diagram
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >4 publications with SART1 and Liver Diseases
 Breast Neoplasms Antibodies  >3 publications with SART1 and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >3 publications with SART1 and Carcinoma, Hepatocellular
 Nervous System Diseases Antibodies  >3 publications with SART1 and Nervous System Diseases
 Kidney Diseases Antibodies  >3 publications with SART1 and Kidney Diseases
 Neoplasm Metastasis Antibodies  >2 publications with SART1 and Neoplasm Metastasis
 Liver Neoplasms Antibodies  >2 publications with SART1 and Liver Neoplasms
 Lung Neoplasms Antibodies  >2 publications with SART1 and Lung Neoplasms
 Necrosis Antibodies  >2 publications with SART1 and Necrosis
 Liver Cirrhosis Antibodies  >1 publications with SART1 and Liver Cirrhosis
Organs/Tissues associated with anti-SART1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >22 publications with SART1 and Blood
 Liver Antibodies  >6 publications with SART1 and Liver
 Brain Antibodies  >4 publications with SART1 and Brain
 Kidney Antibodies  >3 publications with SART1 and Kidney
 Lung Antibodies  >3 publications with SART1 and Lung
 Mouth Antibodies  >2 publications with SART1 and Mouth
 Esophagus Antibodies  >2 publications with SART1 and Esophagus
 Testis Antibodies  >2 publications with SART1 and Testis
 Bone Antibodies  >2 publications with SART1 and Bone
 Vascular Antibodies  >2 publications with SART1 and Vascular
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