NP_001165980.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 81 kDa Predicted: 83 kDa
NCBI Official Full Name
DNA-binding protein SATB2
NCBI Official Synonym Full Names
SATB homeobox 2
NCBI Official Synonym Symbols
NCBI Protein Information
DNA-binding protein SATB2
UniProt Protein Name
DNA-binding protein SATB2
UniProt Synonym Protein Names
Special AT-rich sequence-binding protein 2
UniProt Synonym Gene Names
NCBI Summary for SATB2
This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and cognitive disability. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Feb 2010]
UniProt Comments for SATB2
Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.
Research Articles on SATB2
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Products associated with anti-SATB2 antibody
Diseases associated with anti-SATB2 antibody
Organs/Tissues associated with anti-SATB2 antibody
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