NP_001036.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
sodium-dependent serotonin transporter
NCBI Official Synonym Full Names
solute carrier family 6 member 4
NCBI Official Synonym Symbols
HTT; 5HTT; OCD1; SERT; 5-HTT; SERT1; hSERT; 5-HTTLPR [Similar Products]
NCBI Protein Information
sodium-dependent serotonin transporter
UniProt Protein Name
Sodium-dependent serotonin transporter
UniProt Synonym Protein Names
5HT transporter; 5HTT; Solute carrier family 6 member 4
UniProt Synonym Gene Names
NCBI Summary for SC6A4
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]
UniProt Comments for SC6A4
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.
Research Articles on SC6A4
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Products associated with anti-SC6A4 antibody
Pathways associated with anti-SC6A4 antibody
Diseases associated with anti-SC6A4 antibody
Organs/Tissues associated with anti-SC6A4 antibody
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