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anti-SCN5A antibody :: Goat SCN5A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422777 anti-SCN5A antibody
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SCN5A, Polyclonal Antibody

 Also Known As   

Goat anti-SCN5A (aa1021-1034) Antibody

 Product Synonym Names    Goat Anti-SCN5A Antibody; SCN5A; sodium channel, voltage-gated, type V, alpha subunit; CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1; OTTHUMP00000209279; OTTHUMP00000209280; OTTHUMP00000209281; OTTHUMP00000209282; OTTHUMP00000209283; OTTHUMP00; SCN5A antibody; sodium channel; voltage-gated; type V; alpha subunit antibody; CDCD2 antibody; CMD1E antibody; CMPD2 antibody; HB1 antibody; HB2 antibody; HBBD antibody; HH1 antibody; IVF antibody; LQT3 antibody; Nav1.5 antibody; PFHB1 antibody; SSS1 antibody; VF1 antibody; OTTHUMP00000209279 antibody; SCN5A (aa1021-1034)
 Product Gene Name   

anti-SCN5A antibody

[Similar Products]
 Antibody/Peptide Pairs    SCN5A peptide (MBS427706) is used for blocking the activity of SCN5A antibody (MBS422777)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    PTRKETRFEE GEQP
 OMIM    108770
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-PTRKETRFEEGEQP, from the internal region of the protein sequence according to NP_932173.1; NP_000326.2; NP_001092874.1; NP_001092875.1; NP_001153632.1; NP_001153633.1.
 Epitope    Internal region
 Note    This antibody is expected to recognize all reported isoforms (NP_932173.1; NP_000326.2; NP_001092874.1; NP_001092875.1; NP_001153632.1; NP_001153633.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-SCN5A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SCN5A antibody   

Peptide ELISA (EIA)

 Application Notes for anti-SCN5A antibody    Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Preliminary experiments gave an approx 80kDa band in HeLa lysates after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 227kDa according to NP_932173.1. The 80kDa band was successfully blocked by incubation with the immunizing peptide.
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NCBI/Uniprot data below describe general gene information for SCN5A. It may not necessarily be applicable to this product.
 NCBI GI #    37622907
 NCBI GeneID    6331
 NCBI Accession #    NP_932173.1 [Other Products]
 NCBI Related Accession #    NP_000326.2; NP_001092874.1; NP_001092875.1; NP_001153632.1; NP_001153633.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_198056.2 [Other Products]
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 UniProt Secondary Accession #    Q59H93; Q75RX9; Q75RY0; A5H1P8; A6N922; A6N923; B2RTU0; E7ET19; E9PEF3; E9PEK2; E9PFW7 [Other Products]
 UniProt Related Accession #    Q14524 [Other Products]
 Molecular Weight    224,917 Da
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 NCBI Official Full Name    sodium channel protein type 5 subunit alpha isoform a
 NCBI Official Synonym Full Names    sodium voltage-gated channel alpha subunit 5
 NCBI Official Symbol    SCN5A [Similar Products]
 NCBI Official Synonym Symbols   
HB1; HB2; HH1; IVF; VF1; HBBD; ICCD; LQT3; SSS1; CDCD2; CMD1E; CMPD2; PFHB1; Nav1.5
[Similar Products]
 NCBI Protein Information    sodium channel protein type 5 subunit alpha
 UniProt Protein Name    Sodium channel protein type 5 subunit alpha
 UniProt Synonym Protein Names   
HH1; Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein type V subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.5
 Protein Family    Sodium channel protein
 UniProt Gene Name    SCN5A [Similar Products]
 UniProt Entry Name    SCN5A_HUMAN
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 NCBI Summary for SCN5A    The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SCN5A    SCN5A: an integral membrane protein and a voltage-gated sodium channel subunit. Mediates the voltage-dependent sodium ion permeability of excitable membranes. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. Intracellular calcium levels regulate channel inactivation. Interacts with the PDZ domain of the syntrophin SNTA1, SNTB1 and SNTB2. Interacts with NEDD4, NEDD4L, WWP2 and GPD1L. Defects in this protein are a cause of long QT syndrome type 3 (LQT3). Belongs to the sodium channel (TC 1.A.1.10) family, Nav1.5/SCN5A subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, sodium

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: caveola; cell surface; endoplasmic reticulum; integral to membrane; intracellular; lateral plasma membrane; plasma membrane; sarcolemma; T-tubule; voltage-gated sodium channel complex; Z disc

Molecular Function: ankyrin binding; calmodulin binding; enzyme binding; fibroblast growth factor binding; nitric-oxide synthase binding; protein binding; protein domain specific binding; protein kinase binding; ubiquitin protein ligase binding; voltage-gated sodium channel activity

Biological Process: cardiac muscle contraction; cerebellum development; generation of action potential; membrane depolarization; odontogenesis of dentine-containing teeth; positive regulation of action potential; positive regulation of epithelial cell proliferation; regulation of heart rate; regulation of postsynaptic membrane potential; response to denervation involved in regulation of muscle adaptation; sodium ion transport; telencephalon development

Disease: Atrial Fibrillation, Familial, 10; Brugada Syndrome 1; Cardiomyopathy, Dilated, 1e; Long Qt Syndrome 3; Progressive Familial Heart Block, Type Ia; Sick Sinus Syndrome 1, Autosomal Recessive; Sudden Infant Death Syndrome; Ventricular Fibrillation During Myocardial Infarction, Susceptibility To
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 Research Articles on SCN5A    1. SCN5A gene mutations that reduce sodium channel current may provide a mechanistic link between Atrioventricular nodal reentrant tachycardia and Brugada syndrome and predispose to expression of both phenotypes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SCN5A antibodyPathways associated with anti-SCN5A antibody
 Reference Product  PubMed Publications
 KCNH2 antibody  >201 publications with SCN5A and KCNH2
 SCN3B antibody  >29 publications with SCN5A and SCN3B
 SCN4B antibody  >21 publications with SCN5A and SCN4B
 SCN2B antibody  >14 publications with SCN5A and SCN2B
 FGF12 antibody  >5 publications with SCN5A and FGF12
 ANK3 antibody  >3 publications with SCN5A and ANK3
 CALM2 antibody  >3 publications with SCN5A and CALM2
 FGF13 antibody  >3 publications with SCN5A and FGF13
 CALM1 antibody  >2 publications with SCN5A and CALM1
 UBC antibody  >1 publications with SCN5A and UBC
 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Cardiac Conduction Pathway antibodies  Cardiac Conduction Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Interaction Between L1 And Ankyrins Pathway antibodies  Interaction Between L1 And Ankyrins Pathway Diagram
 L1CAM Interactions Pathway antibodies  L1CAM Interactions Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Phase 0 - Rapid Depolarisation Pathway antibodies  Phase 0 - Rapid Depolarisation Pathway Diagram
Diseases associated with anti-SCN5A antibodyOrgans/Tissues associated with anti-SCN5A antibody
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >1189 publications with SCN5A and Heart Diseases
 Arrhythmias, Cardiac Antibodies  >1182 publications with SCN5A and Arrhythmias, Cardiac
 Brugada Syndrome Antibodies  >579 publications with SCN5A and Brugada Syndrome
 Long QT Syndrome Antibodies  >573 publications with SCN5A and Long QT Syndrome
 Ventricular Fibrillation Antibodies  >236 publications with SCN5A and Ventricular Fibrillation
 Tachycardia, Ventricular Antibodies  >226 publications with SCN5A and Tachycardia, Ventricular
 Syncope Antibodies  >194 publications with SCN5A and Syncope
 Atrial Fibrillation Antibodies  >115 publications with SCN5A and Atrial Fibrillation
 Sudden Infant Death Antibodies  >105 publications with SCN5A and Sudden Infant Death
 Nervous System Diseases Antibodies  >99 publications with SCN5A and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >939 publications with SCN5A and Heart
 Blood Antibodies  >83 publications with SCN5A and Blood
 Brain Antibodies  >51 publications with SCN5A and Brain
 Embryonic Tissue Antibodies  >38 publications with SCN5A and Embryonic Tissue
 Ovary Antibodies  >17 publications with SCN5A and Ovary
 Eye Antibodies  >4 publications with SCN5A and Eye
 Testis Antibodies  >1 publications with SCN5A and Testis
 Uterus Antibodies  >1 publications with SCN5A and Uterus
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