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anti-SCO2 antibody :: Rabbit anti-Human, Mouse SCO cytochrome oxidase deficient homolog 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS712124 anti-SCO2 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SCO cytochrome oxidase deficient homolog 2 (SCO2), Polyclonal Antibody

 Also Known As   

Rabbit anti-human SCO cytochrome oxidase deficient homolog 2 (yeast) polyclonal Antibody

 Product Synonym Names    SCO cytochrome oxidase deficient homolog 2 (yeast); SCO2; MGC125823; MGC125825; SCO1L
 Product Gene Name   

anti-SCO2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608908
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human SCO2
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-49110 / sc-49112 / sc-134778
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-SCO2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SCO2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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NCBI/Uniprot data below describe general gene information for SCO2. It may not necessarily be applicable to this product.
 NCBI GI #    74354511
 NCBI GeneID    9997
 NCBI Accession #    AAI02026.1 [Other Products]
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 UniProt Secondary Accession #    Q3T1B5; Q9UK87 [Other Products]
 UniProt Related Accession #    O43819 [Other Products]
 Molecular Weight    29,810 Da [Similar Products]
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 NCBI Official Full Name    SCO cytochrome oxidase deficient homolog 2 (yeast)
 NCBI Official Synonym Full Names    SCO2 cytochrome c oxidase assembly protein
 NCBI Official Symbol    SCO2 [Similar Products]
 NCBI Official Synonym Symbols   
MYP6; SCO1L; CEMCOX1
[Similar Products]
 NCBI Protein Information    protein SCO2 homolog, mitochondrial; SCO cytochrome oxidase deficient homolog 2
 UniProt Protein Name    Protein SCO2 homolog, mitochondrial
 Protein Family    Protein
 UniProt Gene Name    SCO2 [Similar Products]
 UniProt Entry Name    SCO2_HUMAN
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 NCBI Summary for SCO2    Cytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps to maintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production. Human COX is a multimeric protein complex that requires several assembly factors; this gene encodes one of the COX assembly factors. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidase subunit II. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy and myopia 6. [provided by RefSeq, Oct 2014]
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 UniProt Comments for SCO2    SCO2: Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2). Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC). This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies. Belongs to the SCO1/2 family.

Protein type: Mitochondrial

Chromosomal Location of Human Ortholog: 22q13.33

Cellular Component: nucleoplasm; myofibril; mitochondrion; mitochondrial inner membrane

Molecular Function: copper ion binding

Biological Process: cellular copper ion homeostasis; eye development; in utero embryonic development; respiratory chain complex IV assembly; response to activity; copper ion transport; muscle system process

Disease: Cardioencephalomyopathy, Fatal Infantile, Due To Cytochrome C Oxidase Deficiency 1; Myopia 6
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 Research Articles on SCO2    1. alpha-particle-induced bystander effect is regulated by p53 and its downstream SCO2 in the irradiated hepatoma cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SCO2 antibodyPathways associated with anti-SCO2 antibody
 Reference Product  PubMed Publications
 COX17 antibody  >18 publications with SCO2 and COX17
 SURF1 antibody  >16 publications with SCO2 and SURF1
 COX10 antibody  >14 publications with SCO2 and COX10
 COX11 antibody  >10 publications with SCO2 and COX11
 TP53 antibody  >10 publications with SCO2 and TP53
 COX15 antibody  >6 publications with SCO2 and COX15
 TYMP antibody  >2 publications with SCO2 and TYMP
 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Respiratory Electron Transport Pathway antibodies  Respiratory Electron Transport Pathway Diagram
 Respiratory Electron Transport, ATP Synthesis By Chemiosmotic Coupling, And Heat Production By Uncoupling Proteins. Pathway antibodies  Respiratory Electron Transport, ATP Synthesis By Chemiosmotic Coupling, And Heat Production By Uncoupling Proteins. Pathway Diagram
 The Citric Acid (TCA) Cycle And Respiratory Electron Transport Pathway antibodies  The Citric Acid (TCA) Cycle And Respiratory Electron Transport Pathway Diagram
 Pyrimidine Deoxyribonucleosides Degradation Pathway antibodies  Pyrimidine Deoxyribonucleosides Degradation Pathway Diagram
 Salvage Pathways Of Pyrimidine Deoxyribonucleotides antibodies  Salvage Pathways Of Pyrimidine Deoxyribonucleotides Diagram
Diseases associated with anti-SCO2 antibodyOrgans/Tissues associated with anti-SCO2 antibody
 Disease Name  Pubmed Publications
 Cytochrome-c Oxidase Deficiency Antibodies  >58 publications with SCO2 and Cytochrome-c Oxidase Deficiency
 Cardiovascular Diseases Antibodies  >38 publications with SCO2 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >38 publications with SCO2 and Nervous System Diseases
 Heart Diseases Antibodies  >32 publications with SCO2 and Heart Diseases
 Cardiomyopathies Antibodies  >21 publications with SCO2 and Cardiomyopathies
 Cardiomyopathy, Hypertrophic Antibodies  >19 publications with SCO2 and Cardiomyopathy, Hypertrophic
 Cardioencephalomyopathy, Fatal Infantile, due to Cytochrome C Oxidase Deficiency Antibodies  >12 publications with SCO2 and Cardioencephalomyopathy, Fatal Infantile, due to Cytochrome C Oxidase Deficiency
 Congenital Abnormalities Antibodies  >9 publications with SCO2 and Congenital Abnormalities
 Heart Failure Antibodies  >8 publications with SCO2 and Heart Failure
 Mitochondrial Encephalomyopathies Antibodies  >7 publications with SCO2 and Mitochondrial Encephalomyopathies
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >55 publications with SCO2 and Blood
 Muscle Antibodies  >44 publications with SCO2 and Muscle
 Brain Antibodies  >43 publications with SCO2 and Brain
 Liver Antibodies  >14 publications with SCO2 and Liver
 Lung Antibodies  >9 publications with SCO2 and Lung
 Skin Antibodies  >5 publications with SCO2 and Skin
 Kidney Antibodies  >2 publications with SCO2 and Kidney
 Ganglia Antibodies  >2 publications with SCO2 and Ganglia
 Eye Antibodies  >1 publications with SCO2 and Eye
 Intestine Antibodies  >1 publications with SCO2 and Intestine
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