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anti-SDF-1 BETA antibody :: Goat SDF-1 BETA Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS220170 anti-SDF-1 BETA antibody
Unit / Price
0.05 mg  /  $555 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SDF-1 BETA, Polyclonal Antibody

 Also Known As   

GOAT ANTI HUMAN SDF-1 BETA:Biotin

 Product Gene Name   

anti-SDF-1 BETA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600835
 3D Structure    ModBase 3D Structure for P48061
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Goat
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 Form/Format    Biotin
Purified IgG conjugated to Biotin - lyophilised
 Concentration    IgG concentration 50ug/ml (lot specific)
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 Reconstitution    Reconstitute with 1.0ml sterile PBS containing 0.1% Bovine Serum Albumin. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution. For long term storage the addition of 0.09% sodium azide is recommended.
 Immunogen    Recombinant human SDF-1 beta.
Buffer Solution
 Antiserum Preparation    Antisera to human SDF-1 beta were raised by repeated immunisations of goats with highly purified antigen. Purified IgG prepared by affinity chromatography.
 Target Species    Human
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 Preparation and Storage    Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of reconstitution.
 Other Notes    Small volumes of anti-SDF-1 BETA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SDF-1 BETA antibody

   Goat anti Human SDF-1 beta antibody recognizes human SDF-1 beta, otherwise known as CXCL12b, a 72 amino acid stromal cell derived CXC chemokine, which arises from alternative splicing of the SDF-1 gene. The two isoforms, SDF-1 alpha and SDF-1 beta, share an identical amino acid sequence, except for an additional four residues in the C-Terminal region of the beta isoform. SDF-1 binds with high-affinity to the G protein -coupled receptor CXCR4 (fusin) and acts as a chemoattractant for T and B lymphocytes, monocytes and migratory neurons, and is a vital factor in haematopoiesis and angiogenesis. By competitively binding to CXCR4, SDF-1 acts as an inhibitor for the CXCR4-mediated entry of HIV-1 virus into target T-cells, and the SDF-1-CXCR4 interaction is important for the regulation of trafficking of normal and malignant stem cells.
 Applications Tested/Suitable for anti-SDF-1 BETA antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-SDF-1 BETA antibody    ELISA: Minimum Dilution: 0.15; Maximum Dilution: 0.30ug/ml;
Western Blotting: Minimum Dilution: 0.1; Maximum Dilution: 0.2ug/ml
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NCBI/Uniprot data below describe general gene information for SDF-1 BETA. It may not necessarily be applicable to this product.
 NCBI GI #    10834988
 NCBI GeneID    6387
 NCBI Accession #    NP_000600.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000609.6 [Other Products]
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 UniProt Primary Accession #    P48061 [Other Products]
 UniProt Secondary Accession #    Q2L985; Q2L986; Q2L988; Q5IT36; Q6ICW0; Q9H554; B2R4G0; E7EVL0; H7BYN8 [Other Products]
 UniProt Related Accession #    P48061 [Other Products]
 Molecular Weight    11,004 Da
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 NCBI Official Full Name    stromal cell-derived factor 1 isoform beta
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) ligand 12
 NCBI Official Symbol    CXCL12 [Similar Products]
 NCBI Official Synonym Symbols   
IRH; PBSF; SDF1; TLSF; TPAR1; SCYB12
[Similar Products]
 NCBI Protein Information    stromal cell-derived factor 1; intercrine reduced in hepatomas; pre-B cell growth-stimulating factor
 UniProt Protein Name    Stromal cell-derived factor 1
 UniProt Synonym Protein Names   
C-X-C motif chemokine 12; Intercrine reduced in hepatomas; IRH; hIRH; Pre-B cell growth-stimulating factor; PBSF
 UniProt Gene Name    CXCL12 [Similar Products]
 UniProt Synonym Gene Names    SDF1; SDF1A; SDF1B; SDF-1; hSDF-1; IRH; hIRH; PBSF [Similar Products]
 UniProt Entry Name    SDF1_HUMAN
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 NCBI Summary for SDF-1 BETA    This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
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 UniProt Comments for SDF-1 BETA    CXCL12: Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to another C-X-C chemokine receptor CXCR7, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1- alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3- 67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and CXCR7, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T- cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of CXCR7 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Monomer or homodimer; in equilibrium. Dimer formation is induced by non acidic pH and the presence of multivalent anions, and by binding to CXCR4 or heparin. Monomeric form is required for full chemotactic activity and resistance to ischemia/reperfusion injury, whereas the dimeric form acts as a partial agonist of CXCR4, stimulating Ca2+ mobilization but with no chemotactic activity and instead acts as a selective antagonist that blocks chemotaxis induced by the monomeric form. Interacts with the N- terminus of CXCR7. Isoform Alpha and isoform Beta are ubiquitously expressed, with highest levels detected in liver, pancreas and spleen. Isoform Gamma is mainly expressed in heart, with weak expression detected in several other tissues. Isoform Delta, isoform Epsilon and isoform Theta have highest expression levels in pancreas, with lower levels detected in heart, kidney, liver and spleen. Belongs to the intercrine alpha (chemokine CxC) family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Chemokine; Motility/polarity/chemotaxis; Cell development/differentiation; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 10q11.1

Cellular Component: extracellular space; extracellular region; external side of plasma membrane

Molecular Function: growth factor activity; chemokine activity; chemokine receptor binding; CXCR chemokine receptor binding; receptor binding

Biological Process: response to peptide hormone stimulus; positive regulation of dopamine secretion; positive regulation of cell adhesion; adult locomotory behavior; blood circulation; neuron migration; motor axon guidance; chemotaxis; signal transduction; germ cell development; induction of positive chemotaxis; T cell proliferation; response to radiation; germ cell migration; cell adhesion; organ regeneration; regulation of actin polymerization and/or depolymerization; response to virus; patterning of blood vessels; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; response to heat; response to mechanical stimulus; ameboidal cell migration; positive regulation of axon extension involved in axon guidance; response to hypoxia; immune response; positive regulation of endothelial cell proliferation; telencephalon cell migration

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To
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 Research Articles on SDF-1 BETA    1. Data show that the CXC chemokine receptor 4 (CXCR4) antagonist AMD 3100 disrupted the stromal cell-derived factor 1 (SDF-1alpha)/CXCR4 axis and decreases platelet-derived growth factor B (PDGF-B) protein expression in vivo in two xenograft Ewing tumor models.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SDF-1 BETA antibodyPathways associated with anti-SDF-1 BETA antibody
 Reference Product  PubMed Publications
 CXCR4 antibody  >3342 publications with SDF-1 BETA and CXCR4
 CCR5 antibody  >295 publications with SDF-1 BETA and CCR5
 CXCR7 antibody  >283 publications with SDF-1 BETA and CXCR7
 CXCR3 antibody  >125 publications with SDF-1 BETA and CXCR3
 HIF1A antibody  >82 publications with SDF-1 BETA and HIF1A
 CCR4 antibody  >42 publications with SDF-1 BETA and CCR4
 STAT3 antibody  >42 publications with SDF-1 BETA and STAT3
 JAK2 antibody  >20 publications with SDF-1 BETA and JAK2
 VAV1 antibody  >17 publications with SDF-1 BETA and VAV1
 SDC4 antibody  >5 publications with SDF-1 BETA and SDC4
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Diseases associated with anti-SDF-1 BETA antibodyOrgans/Tissues associated with anti-SDF-1 BETA antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >579 publications with SDF-1 BETA and Cardiovascular Diseases
 Inflammation Antibodies  >572 publications with SDF-1 BETA and Inflammation
 Neoplasm Metastasis Antibodies  >396 publications with SDF-1 BETA and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >271 publications with SDF-1 BETA and Breast Neoplasms
 Heart Diseases Antibodies  >269 publications with SDF-1 BETA and Heart Diseases
 HIV Infections Antibodies  >263 publications with SDF-1 BETA and HIV Infections
 Ischemia Antibodies  >242 publications with SDF-1 BETA and Ischemia
 Neoplasm Invasiveness Antibodies  >236 publications with SDF-1 BETA and Neoplasm Invasiveness
 Lung Diseases Antibodies  >224 publications with SDF-1 BETA and Lung Diseases
 Necrosis Antibodies  >222 publications with SDF-1 BETA and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1503 publications with SDF-1 BETA and Bone
 Bone Marrow Antibodies  >1375 publications with SDF-1 BETA and Bone Marrow
 Vascular Antibodies  >1104 publications with SDF-1 BETA and Vascular
 Brain Antibodies  >500 publications with SDF-1 BETA and Brain
 Muscle Antibodies  >372 publications with SDF-1 BETA and Muscle
 Lung Antibodies  >341 publications with SDF-1 BETA and Lung
 Heart Antibodies  >307 publications with SDF-1 BETA and Heart
 Liver Antibodies  >282 publications with SDF-1 BETA and Liver
 Embryonic Tissue Antibodies  >211 publications with SDF-1 BETA and Embryonic Tissue
 Nerve Antibodies  >173 publications with SDF-1 BETA and Nerve
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