NP_001036096.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
12,806 Da
NCBI Official Full Name
succinate dehydrogenase assembly factor 1, mitochondrial
NCBI Official Synonym Full Names
succinate dehydrogenase complex assembly factor 1
NCBI Official Synonym Symbols
NCBI Protein Information
succinate dehydrogenase assembly factor 1, mitochondrial
UniProt Protein Name
Succinate dehydrogenase assembly factor 1, mitochondrial
UniProt Synonym Protein Names
LYR motif-containing protein 8
UniProt Synonym Gene Names
NCBI Summary for SDHAF1
The succinate dehydrogenase (SDH) complex (or complex II) of the mitochondrial respiratory chain is composed of 4 individual subunits. The protein encoded by this gene resides in the mitochondria, and is essential for SDH assembly, but does not physically associate with the complex in vivo. Mutations in this gene are associated with SDH-defective infantile leukoencephalopathy (mitochondrial complex II deficiency).[provided by RefSeq, Mar 2010]
UniProt Comments for SDHAF1
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3.
Research Articles on SDHAF1
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Products associated with anti-SDHAF1 antibody
Diseases associated with anti-SDHAF1 antibody
Organs/Tissues associated with anti-SDHAF1 antibody
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