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anti-SDHB antibody :: Goat SDHB Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421127
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SDHB, Polyclonal Antibody

 Also Known As   

Goat anti-SDHB Antibody

 Product Synonym Names    Goat Anti-SDHB, Biotinylated Antibody; SDHB; IP; SDH; SDH1; SDHIP; succinate dehydrogenase complex, subunit B, iron sulfur (Ip); OTTHUMP00000044624; iron-sulfur subunit; FLJ92337; PGL4; SDH2; SDHIP; SDHB antibody; IP antibody; SDH antibody; SDH1 antibody; SDHIP antibody; succinate dehydrogenase complex; subunit B; iron sulfur (Ip) antibody; OTTHUMP00000044624 antibody; iron-sulfur subunit antibody; FLJ92337 antibody; SDH2 antibody; SDHIP antibody
 Product Gene Name   

anti-SDHB antibody

[Similar Products]
 Matching Pairs    Unconjugated Antibody: SDHB (MBS421127)
Biotin Conjugated Antibody: SDHB (MBS423534)
 Antibody/Peptide Pairs    SDHB peptide (MBS425682) is used for blocking the activity of SDHB antibody (MBS421127)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    ATYKEKKASV
 OMIM    115310
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-ATYKEKKASV, from the C Terminus of the protein sequence according to NP_002991.2.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-SDHB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SDHB antibody   

Peptide ELISA (EIA), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-SDHB antibody    Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Approx 28kDa band observed in Human Liver lysates (calculated MW of 31.6kDa according to NP_002991.1). Recommended concentration: 0. 03-0.1ug/ml.
ELISA: Customer successfully used this product in quantitative ELISA on HepG2 lysates.
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 Western Blot (WB) of anti-SDHB antibody    (0. 03ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-SDHB antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SDHB. It may not necessarily be applicable to this product.
 NCBI GI #    115387094
 NCBI GeneID    6390
 NCBI Accession #    NP_002991.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003000.2 [Other Products]
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 UniProt Secondary Accession #    Q0QEY7; Q9NQ12; B2R545 [Other Products]
 UniProt Related Accession #    P21912 [Other Products]
 Molecular Weight    31,630 Da
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 NCBI Official Full Name    succinate dehydrogenase
 NCBI Official Synonym Full Names    succinate dehydrogenase complex iron sulfur subunit B
 NCBI Official Symbol    SDHB [Similar Products]
 NCBI Official Synonym Symbols   
IP; SDH; CWS2; PGL4; SDH1; SDH2; SDHIP
[Similar Products]
 NCBI Protein Information    succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
 UniProt Protein Name    Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
 UniProt Synonym Protein Names   
Iron-sulfur subunit of complex II; Ip
 Protein Family    Succinate dehydrogenase
 UniProt Gene Name    SDHB [Similar Products]
 UniProt Synonym Gene Names    SDH; SDH1; Ip [Similar Products]
 UniProt Entry Name    SDHB_HUMAN
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 NCBI Summary for SDHB    Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SDHB    SDHB: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Defects in SDHB are a cause of susceptibility to pheochromocytoma (PCC). A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent. Defects in SDHB are the cause of paragangliomas type 4 (PGL4). A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion. Paragangliomas are most commonly located in the head and neck region, specifically at the carotid bifurcation, the jugular foramen, the vagal nerve, and in the middle ear. Defects in SDHB are a cause of paraganglioma and gastric stromal sarcoma (PGGSS); also called Carney-Stratakis syndrome. Gastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominant manner, alone or as a component of a syndrome associated with other tumors, such as in the context of neurofibromatosis type 1 (NF1). Patients have both gastrointestinal stromal tumors and paragangliomas. Susceptibility to the tumors was inherited in an apparently autosomal dominant manner, with incomplete penetrance. Defects in SDHB are a cause of Cowden-like syndrome (CWDLS). Cowden-like syndrome is a cancer predisposition syndrome associated with elevated risk for tumors of the breast, thyroid, kidney and uterus. Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Protein type: EC 1.3.5.1; Carbohydrate Metabolism - citrate (TCA) cycle; Energy Metabolism - oxidative phosphorylation; Oxidoreductase; Mitochondrial

Chromosomal Location of Human Ortholog: 1p36.1-p35

Cellular Component: mitochondrial inner membrane; mitochondrial respiratory chain complex II; mitochondrion; nucleoplasm; plasma membrane

Molecular Function: 2 iron, 2 sulfur cluster binding; 3 iron, 4 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; electron carrier activity; metal ion binding; protein binding; succinate dehydrogenase (ubiquinone) activity; ubiquinone binding

Biological Process: aerobic respiration; succinate metabolic process; tricarboxylic acid cycle

Disease: Cowden Syndrome 2; Gastrointestinal Stromal Tumor; Paraganglioma And Gastric Stromal Sarcoma; Paragangliomas 4; Pheochromocytoma
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 Research Articles on SDHB    1. 15 YEARS OF PARAGANGLIOMA: Genetics and mechanism of pheochromocytoma-paraganglioma syndromes characterized by germline SDHB and SDHD mutations
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SDHB antibodyPathways associated with anti-SDHB antibody
 Reference Product  PubMed Publications
 SDHD antibody  >430 publications with SDHB and SDHD
 SDHC antibody  >329 publications with SDHB and SDHC
 SDHA antibody  >180 publications with SDHB and SDHA
 UQCRC2 antibody  >2 publications with SDHB and UQCRC2
 SUCLG1 antibody  >1 publications with SDHB and SUCLG1
 CYC1 antibody  >1 publications with SDHB and CYC1
 UQCRFS1 antibody  >1 publications with SDHB and UQCRFS1
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
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 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway Diagram
 Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway antibodies  Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway Diagram
 Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway antibodies  Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway Diagram
Diseases associated with anti-SDHB antibodyOrgans/Tissues associated with anti-SDHB antibody
 Disease Name  Pubmed Publications
 Paraganglioma Antibodies  >526 publications with SDHB and Paraganglioma
 Pheochromocytoma Antibodies  >364 publications with SDHB and Pheochromocytoma
 Nervous System Diseases Antibodies  >81 publications with SDHB and Nervous System Diseases
 Hypertension Antibodies  >61 publications with SDHB and Hypertension
 Cardiovascular Diseases Antibodies  >59 publications with SDHB and Cardiovascular Diseases
 Kidney Diseases Antibodies  >41 publications with SDHB and Kidney Diseases
 Neoplasm Metastasis Antibodies  >27 publications with SDHB and Neoplasm Metastasis
 Carney-Stratakis Syndrome Antibodies  >21 publications with SDHB and Carney-Stratakis Syndrome
 Neoplasms, Experimental Antibodies  >20 publications with SDHB and Neoplasms, Experimental
 Heart Diseases Antibodies  >19 publications with SDHB and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Adrenal Gland Antibodies  >243 publications with SDHB and Adrenal Gland
 Blood Antibodies  >71 publications with SDHB and Blood
 Kidney Antibodies  >54 publications with SDHB and Kidney
 Vascular Antibodies  >45 publications with SDHB and Vascular
 Thyroid Antibodies  >38 publications with SDHB and Thyroid
 Liver Antibodies  >29 publications with SDHB and Liver
 Lymph Antibodies  >27 publications with SDHB and Lymph
 Muscle Antibodies  >25 publications with SDHB and Muscle
 Bone Antibodies  >23 publications with SDHB and Bone
 Brain Antibodies  >22 publications with SDHB and Brain
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