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anti-SEK1 antibody :: Rabbit SEK1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2536154
Western Blot (WB)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SEK1, Polyclonal Antibody

★Popular Item★
 Also Known As   

SEK1 Polyclonal Antibody

 Product Synonym Names    MAP2K4; JNKK1; MEK4; MKK4; PRKMK4; SEK1; SERK1; SKK1; Dual specificity mitogen-activated protein kinase kinase 4; MAP kinase kinase 4; MAPKK 4; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated pro
 Product Gene Name   

anti-SEK1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
 Concentration    1 mg/ml (lot specific)
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 Immunogen    Synthesized peptide derived from the C-terminal region of human SEK1.
 Buffer    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-SEK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SEK1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-SEK1 antibody    WB: 1:500-1:2000, IHC: 1:50-1:200, IF: 1:50-1:100, ELISA: 1:5000-1:20000
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 Western Blot (WB) of anti-SEK1 antibody    Western Blot analysis of 293 cells with SEK1 Polyclonal Antibody.
anti-SEK1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SEK1. It may not necessarily be applicable to this product.
 NCBI GI #    1754531
 NCBI GeneID    26398
 NCBI Accession #    AAB81554.1 [Other Products]
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 UniProt Related Accession #    P47809 [Other Products]
 Molecular Weight    Calculated MW: 44
Observed MW: 44
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 NCBI Official Full Name    SEK1
 NCBI Official Synonym Full Names    mitogen-activated protein kinase kinase 4
 NCBI Official Symbol    Map2k4 [Similar Products]
 NCBI Official Synonym Symbols   
MEK4; MKK4; Sek1; JNKK1; Serk1; PRKMK4
[Similar Products]
 NCBI Protein Information    dual specificity mitogen-activated protein kinase kinase 4
 UniProt Protein Name    Dual specificity mitogen-activated protein kinase kinase 4
 UniProt Synonym Protein Names   
C-JUN N-terminal kinase kinase 1; JNK kinase 1; JNKK 1; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1
 UniProt Gene Name    Map2k4 [Similar Products]
 UniProt Synonym Gene Names    Jnkk1; Mek4; Mkk4; Prkmk4; Sek1; Serk1; Skk1; MAP kinase kinase 4; MAPKK 4; JNK kinase 1; JNKK 1; MEK 4; SEK1 [Similar Products]
 UniProt Entry Name    MP2K4_MOUSE
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 UniProt Comments for SEK1    MKK4: dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38 but not ERK1 or -2. Mediates cellular responses to various cellular stresses and inflammatory cytokines. Phosphorylation by Akt inhibits MKK4 and suppresses stress-activated signal transduction.

Protein type: Protein kinase, STE; Kinase, protein; EC 2.7.12.2; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family

Cellular Component: axon; cytoplasm; cytosol; dendrite cytoplasm; nucleus; perikaryon

Molecular Function: ATP binding; JUN kinase kinase activity; kinase activity; MAP kinase kinase activity; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity; transferase activity

Biological Process: activation of JNK activity; activation of protein kinase activity; apoptosis; JNK cascade; MAPKKK cascade; phosphorylation; positive regulation of apoptosis; positive regulation of DNA replication; positive regulation of neuron apoptosis; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of protein amino acid phosphorylation; protein amino acid phosphorylation; regulation of mitotic cell cycle; response to wounding; stress-activated protein kinase signaling pathway
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 Research Articles on SEK1    1. Demonstrate that Mkk4 is a negative regulator of the TGF-beta1 signaling associated with atrial remodeling and arrhythmogenesis with age.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SEK1 antibodyPathways associated with anti-SEK1 antibody
 Reference Product  PubMed Publications
 Map2k7 antibody  >65 publications with SEK1 and Map2k7
 Map3k1 antibody  >44 publications with SEK1 and Map3k1
 Mapk8 antibody  >31 publications with SEK1 and Mapk8
 Map3k5 antibody  >17 publications with SEK1 and Map3k5
 Rac1 antibody  >10 publications with SEK1 and Rac1
 Cd40 antibody  >3 publications with SEK1 and Cd40
 Mapk8ip3 antibody  >1 publications with SEK1 and Mapk8ip3
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
Diseases associated with anti-SEK1 antibodyOrgans/Tissues associated with anti-SEK1 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >57 publications with SEK1 and Necrosis
 Inflammation Antibodies  >21 publications with SEK1 and Inflammation
 Breast Neoplasms Antibodies  >21 publications with SEK1 and Breast Neoplasms
 Adenocarcinoma Antibodies  >20 publications with SEK1 and Adenocarcinoma
 Lung Neoplasms Antibodies  >14 publications with SEK1 and Lung Neoplasms
 Pancreatic Neoplasms Antibodies  >13 publications with SEK1 and Pancreatic Neoplasms
 Brain Diseases Antibodies  >12 publications with SEK1 and Brain Diseases
 Lung Diseases Antibodies  >12 publications with SEK1 and Lung Diseases
 Neoplasms, Experimental Antibodies  >11 publications with SEK1 and Neoplasms, Experimental
 Prostatic Neoplasms Antibodies  >11 publications with SEK1 and Prostatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >48 publications with SEK1 and Blood
 Brain Antibodies  >25 publications with SEK1 and Brain
 Lung Antibodies  >22 publications with SEK1 and Lung
 Liver Antibodies  >19 publications with SEK1 and Liver
 Kidney Antibodies  >14 publications with SEK1 and Kidney
 Bone Antibodies  >10 publications with SEK1 and Bone
 Skin Antibodies  >10 publications with SEK1 and Skin
 Lymph Node Antibodies  >6 publications with SEK1 and Lymph Node
 Heart Antibodies  >6 publications with SEK1 and Heart
 Embryonic Tissue Antibodies  >6 publications with SEK1 and Embryonic Tissue
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