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anti-SENP1 antibody :: Rabbit anti-Human, Mouse SENP1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7051445
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SENP1, Polyclonal Antibody

★Popular Item★
 Also Known As   

SENP1 Antibody

 Product Synonym Names    Sentrin-specific protease 1; Sentrin/SUMO-specific protease SENP1; SENP1
 Product Gene Name   

anti-SENP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF149770 mRNA
 3D Structure    ModBase 3D Structure for Q9P0U3
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Sentrin-specific protease 1 protein (63-214AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, PH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-46634 / sc-67074
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-SENP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SENP1 antibody

   Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1. Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed: 25406032).
 Applications Tested/Suitable for anti-SENP1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-SENP1 antibody    WB: 1: 500-1: 5000
IHC: 1: 20-1: 200
IF: 1: 50-1: 200
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 Western Blot (WB) of anti-SENP1 antibody    Western Blot
Positive WB detected in:Hela whole cell lysate,HL60 whole cell lysate,Jurkat whole cell lysate,Mouse heart tissue,Mouse brain tissue,Mouse spleen tissue,Mouse stomach tissue,Mouse skeletal muscle tissue
All lanes: SENP1 antibody at 2.7ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 74 kDa
Observed band size: 74,50 kDa

anti-SENP1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-SENP1 antibody    Immunohistochemistry of paraffin-embedded human colon cancer using MBS7051445 at dilution of 1:100
anti-SENP1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-SENP1 antibody    Immunofluorescent analysis of Hela cells using MBS7051445 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-SENP1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for SENP1. It may not necessarily be applicable to this product.
 NCBI GI #    390131988
 NCBI GeneID    29843
 NCBI Accession #    NP_001254523.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001267594.1 [Other Products]
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 UniProt Primary Accession #    Q9P0U3 [Other Products]
 UniProt Secondary Accession #    Q86XC8; A8K7P5 [Other Products]
 UniProt Related Accession #    Q9P0U3 [Other Products]
 Molecular Weight    73,351 Da
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 NCBI Official Full Name    sentrin-specific protease 1
 NCBI Official Synonym Full Names    SUMO1/sentrin specific peptidase 1
 NCBI Official Symbol    SENP1 [Similar Products]
 NCBI Official Synonym Symbols   
SuPr-2
[Similar Products]
 NCBI Protein Information    sentrin-specific protease 1
 UniProt Protein Name    Sentrin-specific protease 1
 UniProt Synonym Protein Names   
Sentrin/SUMO-specific protease SENP1
 Protein Family    Sentrin-specific protease
 UniProt Gene Name    SENP1 [Similar Products]
 UniProt Entry Name    SENP1_HUMAN
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 NCBI Summary for SENP1    This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
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 UniProt Comments for SENP1    SENP1: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity. Belongs to the peptidase C48 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.22.68; Nuclear receptor co-regulator; Protease

Chromosomal Location of Human Ortholog: 12q13.1

Cellular Component: focal adhesion; nuclear membrane; nucleoplasm; nucleus

Molecular Function: endopeptidase activity; protein binding; SUMO-specific protease activity

Biological Process: caspase activation; positive regulation of transcription from RNA polymerase II promoter; protein desumoylation; protein sumoylation; proteolysis
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 Research Articles on SENP1    1. Genetic interactions of SNPs in CARD14, SENP1 and VEGFA might represent a functional mechanism in the pathogenesis of high altitude polycythemia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SENP1 antibodyPathways associated with anti-SENP1 antibody
 Reference Product  PubMed Publications
 SUMO1 antibody  >116 publications with SENP1 and SUMO1
 SUMO2 antibody  >23 publications with SENP1 and SUMO2
 SUMO3 antibody  >13 publications with SENP1 and SUMO3
 RANGAP1 antibody  >7 publications with SENP1 and RANGAP1
 GATA1 antibody  >2 publications with SENP1 and GATA1
 HDAC1 antibody  >2 publications with SENP1 and HDAC1
 BCL11B antibody  >1 publications with SENP1 and BCL11B
 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Processing And Activation Of SUMO Pathway antibodies  Processing And Activation Of SUMO Pathway Diagram
 Regulation Of Androgen Receptor Activity Pathway antibodies  Regulation Of Androgen Receptor Activity Pathway Diagram
 SUMO Is Proteolytically Processed Pathway antibodies  SUMO Is Proteolytically Processed Pathway Diagram
 SUMOylation Pathway antibodies  SUMOylation Pathway Diagram
Diseases associated with anti-SENP1 antibodyOrgans/Tissues associated with anti-SENP1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >21 publications with SENP1 and Inflammation
 Prostatic Neoplasms Antibodies  >13 publications with SENP1 and Prostatic Neoplasms
 Cardiovascular Diseases Antibodies  >8 publications with SENP1 and Cardiovascular Diseases
 Cell Transformation, Neoplastic Antibodies  >5 publications with SENP1 and Cell Transformation, Neoplastic
 Neoplasm Metastasis Antibodies  >3 publications with SENP1 and Neoplasm Metastasis
 Disease Models, Animal Antibodies  >3 publications with SENP1 and Disease Models, Animal
 Hypertension Antibodies  >3 publications with SENP1 and Hypertension
 Ovarian Neoplasms Antibodies  >2 publications with SENP1 and Ovarian Neoplasms
 Neoplasms, Experimental Antibodies  >2 publications with SENP1 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >2 publications with SENP1 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >22 publications with SENP1 and Prostate
 Blood Antibodies  >14 publications with SENP1 and Blood
 Brain Antibodies  >13 publications with SENP1 and Brain
 Vascular Antibodies  >12 publications with SENP1 and Vascular
 Pancreas Antibodies  >9 publications with SENP1 and Pancreas
 Lung Antibodies  >9 publications with SENP1 and Lung
 Liver Antibodies  >6 publications with SENP1 and Liver
 Kidney Antibodies  >6 publications with SENP1 and Kidney
 Lymph Node Antibodies  >5 publications with SENP1 and Lymph Node
 Muscle Antibodies  >4 publications with SENP1 and Muscle
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