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anti-SEPT4 antibody :: Rabbit anti-Human SEPT4 / Septin 4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240374
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SEPT4 / Septin 4, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human SEPT4 / Septin 4

 Product Synonym Names    Anti-SEPT4 / Septin 4 Antibody (N-Terminus) IHC-plus; SEPT4; Brain protein H5; ARTS; BRADEION; CE5B3; Cerebral protein 7; H5; HCDCREL-2; Peanut-like 2 (Drosophila); PNUTL2; SEP4; Septin 4; Bradeion beta; CE5B3 beta; Hucep-7; MART; Peanut-like protein 2; Septin-4; Septin-M; Human SEPT4; Septin 4
 Product Gene Name   

anti-SEPT4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603696
 3D Structure    ModBase 3D Structure for O43236
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    synthetic peptide corresponding to amino acids near the amino terminus of human ARTS
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.02% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human SEPT4 / Septin 4.
 Immunogen Type    Synthetic peptide
 Immunogen    SEPT4 / Septin 4 antibody was raised against synthetic peptide from human SEPT4 / Septin 4.
 Antigen Modification    N-Terminus
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
 Other Notes    Small volumes of anti-SEPT4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-SEPT4 antibody

   Apoptosis is related to many diseases and development. Mitochondrial proteins, such as cytochrome c, Apaf-1, and AIF play important role in apoptosis. A novel mitochondrial septin-like protein was identified recently and designated ARTS for apoptosis related protein in TGF-b signaling pathway. ARTS that is encoded by the human septin H5/PNUTL2/CDCrel2b gene is located to mitochondria and translocates to the nucleus when apoptosis occurs. ARTS is expressed in many tissues.
 Product Categories/Family for anti-SEPT4 antibody    Family: Apoptosis
 Applications Tested/Suitable for anti-SEPT4 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

 Application Notes for anti-SEPT4 antibody    IHC-P (2.5 ug/ml), WB (0.5 - 2 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
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 Immunohistochemistry (IHC) of anti-SEPT4 antibody    Anti-SEPT4 / Septin 4 antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-SEPT4 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-SEPT4 antibody    Anti-SEPT4 / Septin 4 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-SEPT4 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-SEPT4 antibody    Immunofluorescence of ARTS in Human Lung cells with ARTS antibody at 20 ug/ml.
anti-SEPT4 antibody Immunofluorescence (IF) image
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 Western Blot (WB) of anti-SEPT4 antibody    Western blot of ARTS expression in human lung (lane 1), spleen (lane 2), and kidney (lane 3) tissue lysates with ARTS antibody at 2 ug /ml.
anti-SEPT4 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SEPT4. It may not necessarily be applicable to this product.
 NCBI GI #    4758942
 NCBI GeneID    5414
 NCBI Accession #    NP_004565.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004574.4 [Other Products]
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 UniProt Primary Accession #    O43236 [Other Products]
 UniProt Secondary Accession #    Q6IAP3; Q9H315; Q9UM58; B2RD42; B3KSX9; B4DXC6; B4DXV5 [Other Products]
 UniProt Related Accession #    O43236 [Other Products]
 Molecular Weight    30,809 Da
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 NCBI Official Full Name    septin-4 isoform 1
 NCBI Official Synonym Full Names    septin 4
 NCBI Official Symbol    SEPT4 [Similar Products]
 NCBI Official Synonym Symbols   
H5; ARTS; MART; SEP4; CE5B3; PNUTL2; hucep-7; BRADEION; hCDCREL-2
[Similar Products]
 NCBI Protein Information    septin-4; septin-M; CE5B3 beta; bradeion beta; brain protein H5; cerebral protein 7; peanut-like protein 2; cell division control-related protein 2; apoptosis-related protein in the TGF-beta signaling pathway
 UniProt Protein Name    Septin-4
 UniProt Synonym Protein Names   
Apoptosis-related protein in the TGF-beta signaling pathway; ARTS; Bradeion beta; Brain protein H5; CE5B3 beta; Cell division control-related protein 2; hCDCREL-2; Cerebral protein 7; Peanut-like protein 2
 UniProt Gene Name    SEPT4 [Similar Products]
 UniProt Synonym Gene Names    ARTS; PNUTL2; SEP4; ARTS; hCDCREL-2 [Similar Products]
 UniProt Entry Name    SEPT4_HUMAN
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 NCBI Summary for SEPT4    This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. [provided by RefSeq, Nov 2010]
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 UniProt Comments for SEPT4    SEPT4: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli. Belongs to the septin family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; Cell development/differentiation; Apoptosis; Cytoskeletal

Chromosomal Location of Human Ortholog: 17q22

Cellular Component: cytoskeleton; mitochondrion; nucleus

Molecular Function: GTPase activity; protein binding; GTP binding; structural molecule activity

Biological Process: regulation of apoptosis; sperm mitochondrion organization and biogenesis; apoptosis; metabolic process; positive regulation of apoptosis; cell division; positive regulation of protein ubiquitination; brain development; cell cycle; sperm capacitation
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 Research Articles on SEPT4    1. results suggest that Septin4 may be involved in the process of activation of hepatic stellate cells by lipopolysaccharide stimulation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SEPT4 antibodyPathways associated with anti-SEPT4 antibody
 Reference Product  PubMed Publications
 XIAP antibody  >12 publications with SEPT4 and XIAP
 SEPT8 antibody  >7 publications with SEPT4 and SEPT8
 SEPT14 antibody  >2 publications with SEPT4 and SEPT14
 RTKN antibody  >1 publications with SEPT4 and RTKN
 Products by Pathway  Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
Diseases associated with anti-SEPT4 antibodyOrgans/Tissues associated with anti-SEPT4 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >13 publications with SEPT4 and Nervous System Diseases
 Brain Diseases Antibodies  >12 publications with SEPT4 and Brain Diseases
 Liver Diseases Antibodies  >6 publications with SEPT4 and Liver Diseases
 Disease Models, Animal Antibodies  >5 publications with SEPT4 and Disease Models, Animal
 Fibrosis Antibodies  >4 publications with SEPT4 and Fibrosis
 Inflammation Antibodies  >3 publications with SEPT4 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >2 publications with SEPT4 and Carcinoma, Hepatocellular
 Congenital Abnormalities Antibodies  >2 publications with SEPT4 and Congenital Abnormalities
 Liver Neoplasms Antibodies  >2 publications with SEPT4 and Liver Neoplasms
 Atrophy Antibodies  >1 publications with SEPT4 and Atrophy
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >18 publications with SEPT4 and Brain
 Nerve Antibodies  >11 publications with SEPT4 and Nerve
 Liver Antibodies  >7 publications with SEPT4 and Liver
 Testis Antibodies  >4 publications with SEPT4 and Testis
 Muscle Antibodies  >4 publications with SEPT4 and Muscle
 Heart Antibodies  >3 publications with SEPT4 and Heart
 Embryonic Tissue Antibodies  >3 publications with SEPT4 and Embryonic Tissue
 Adrenal Gland Antibodies  >2 publications with SEPT4 and Adrenal Gland
 Bone Antibodies  >2 publications with SEPT4 and Bone
 Skin Antibodies  >2 publications with SEPT4 and Skin
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