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anti-ATP2A1 antibody :: Rabbit SERCA1 ATPase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175483
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SERCA1 ATPase (ATP2A1), Polyclonal Antibody

 Also Known As   

Anti-SERCA1 ATPase antibody

 Product Synonym Names    Sarcoplasmic/endoplasmic reticulum calcium ATPase 1(SERCA1/SR Ca(2+)-ATPase 1); ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; fast twitch skeletal muscle isoform antibody; AT2A1_HUMAN antibody; ATP2A antibody; ATP2A1 antibody; ATPase Ca++ transporting cardiac muscle fast twitch 1 antibody; ATPase Ca++ transporting fast twitch 1 antibody; ATPase, Ca(2+)-transporting fast twitch 1 antibody; Calcium pump 1 antibody; Calcium transporting ATPase sarcoplasmic reticulum type fast twitch skeletal muscle isoform antibody; Calcium-transporting ATPase sarcoplasmic reticulum type antibody; EC 3.6.3.8 antibody; Endoplasmic reticulum class 1/2 Ca(2+) ATPase antibody; Fast skeletal muscle SR calcium ATPase antibody; fast twitch skeletal muscle isoform antibody; OTTHUMP00000162561 antibody; OTTHUMP00000162562 antibody; Sarcoendoplasmic reticulum calcium ATPase antibody; Sarcoplasmic reticulum Ca(2+)-ATPase 1 antibody; Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 antibody; SERCA 1 antibody; SERCA1 antibody; SERCA1 truncated isoform, included antibody; SR Ca(2+) ATPase 1 antibody; SR Ca(2+)-ATPase 1 antibody
 Product Gene Name   

anti-ATP2A1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 601003
 3D Structure    ModBase 3D Structure for O14983
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence in the middle region of human SERCA1 ATPase (665-680aa EQREACRRACCFARVE), identical to the related rat and mouse sequences.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ATP2A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ATP2A1 antibody

   Description: Rabbit IgG polyclonal antibody for Sarcoplasmic/endoplasmic reticulum calcium ATPase 1(ATP2A1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Background: SERCA1(SARCOPLASMIC RETICULUM Ca(2+)-ATPase 1), also called ATP2A1, is an enzyme that in humans is encoded by the ATP2A1 gene. This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. The SERCA1 gene is mapped on 16p11.2. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Zhang et al.(1995)determined that the human ATP2A1 gene is 26 kb long and contains 23 exons, 1 of which can be alternatively spliced.Overexpression of S1T, but not full-length SERCA1, induced ER stress in HeLa cells and amplified ER stress through the PERK(EIF2AK3)-EIF2A -ATF4 -CHOP(DDIT3) pathway. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise.
 Applications Tested/Suitable for anti-ATP2A1 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

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 Western Blot (WB) of anti-ATP2A1 antibody    Anti-SERCA1 ATPase antibody, MBS175483, Western blotting
Lane 1: Rat Skeletal Muscle Tissue Lysate
Lane 2: PANC Cell Lysate
Lane 3: U87 Cell Lysate

anti-ATP2A1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ATP2A1 antibody    Anti-SERCA1 ATPase antibody, MBS175483, IHC(P)
IHC(P): Human Placenta Tissue
anti-ATP2A1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ATP2A1 antibody    Anti-SERCA1 ATPase antibody, MBS175483, IHC(P)
IHC(P): Rat Skeletal Muscle Tissue
anti-ATP2A1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ATP2A1. It may not necessarily be applicable to this product.
 NCBI GI #    12643544
 NCBI GeneID    487
 NCBI Accession #    O14983.1 [Other Products]
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 UniProt Primary Accession #    O14983 [Other Products]
 UniProt Secondary Accession #    O14984; A8K5J9; B3KY17 [Other Products]
 UniProt Related Accession #    O14983 [Other Products]
 Molecular Weight    95,199 Da
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 NCBI Official Full Name    Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
 NCBI Official Synonym Full Names    ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
 NCBI Official Symbol    ATP2A1 [Similar Products]
 NCBI Official Synonym Symbols   
ATP2A; SERCA1
[Similar Products]
 NCBI Protein Information    sarcoplasmic/endoplasmic reticulum calcium ATPase 1; calcium pump 1; SR Ca(2+)-ATPase 1; endoplasmic reticulum class 1/2 Ca(2+) ATPase; calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform
 UniProt Protein Name    Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
 UniProt Synonym Protein Names   
Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase
 Protein Family    Sarcoplasmic/endoplasmic reticulum calcium ATPase
 UniProt Gene Name    ATP2A1 [Similar Products]
 UniProt Synonym Gene Names    SERCA1; SR Ca(2+)-ATPase 1 [Similar Products]
 UniProt Entry Name    AT2A1_HUMAN
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 NCBI Summary for ATP2A1    This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Oct 2013]
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 UniProt Comments for ATP2A1    ATP2A1: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. Associated with sarcolipin (SLN) and phospholamban (PLN). Increased contractile activity leads to a decrease in SERCA1 expression, while decreased contractile activity leads to an increase in SERCA1 expression. Skeletal muscle, fast twitch muscle (type II) fibers. Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Transporter, ion channel; Hydrolase; Membrane protein, multi-pass; Endoplasmic reticulum; Membrane protein, integral; EC 3.6.3.8

Chromosomal Location of Human Ortholog: 16p12.1

Cellular Component: I band; endoplasmic reticulum membrane; sarcoplasmic reticulum membrane; membrane; sarcoplasmic reticulum; perinuclear region of cytoplasm; ER-Golgi intermediate compartment; integral to membrane

Molecular Function: protein binding; protein homodimerization activity; calcium-transporting ATPase activity; calcium ion binding; ATP binding

Biological Process: apoptotic mitochondrial changes; metabolic process; positive regulation of fast-twitch skeletal muscle contraction; maintenance of mitochondrion localization; elevation of endoplasmic reticulum calcium ion concentration; reduction of endoplasmic reticulum calcium ion concentration; calcium ion transport; regulation of striated muscle contraction; blood coagulation; transmembrane transport; elevation of mitochondrial calcium ion concentration; negative regulation of striated muscle contraction

Disease: Brody Myopathy
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 Research Articles on ATP2A1    1. We performed a detailed study of SERCA1 protein expression in muscle of patients with BD and BS, and evaluated the alternative splicing of SERCA1 in primary cultures of normal human muscle
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ATP2A1 antibodyPathways associated with anti-ATP2A1 antibody
 Reference Product  PubMed Publications
 SLN antibody  >3 publications with ATP2A1 and SLN
 PLN antibody  >3 publications with ATP2A1 and PLN
 CKM antibody  >2 publications with ATP2A1 and CKM
 TNNC2 antibody  >2 publications with ATP2A1 and TNNC2
 CACNA1S antibody  >1 publications with ATP2A1 and CACNA1S
 IRS1 antibody  >1 publications with ATP2A1 and IRS1
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Ion Transport By P-type ATPases Pathway antibodies  Ion Transport By P-type ATPases Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram
Diseases associated with anti-ATP2A1 antibodyOrgans/Tissues associated with anti-ATP2A1 antibody
 Disease Name  Pubmed Publications
 Heart Failure Antibodies  >7 publications with ATP2A1 and Heart Failure
 Brody myopathy Antibodies  >4 publications with ATP2A1 and Brody myopathy
 Weight Loss Antibodies  >3 publications with ATP2A1 and Weight Loss
 Hypertrophy Antibodies  >3 publications with ATP2A1 and Hypertrophy
 Fibrosis Antibodies  >2 publications with ATP2A1 and Fibrosis
 Brain Diseases Antibodies  >2 publications with ATP2A1 and Brain Diseases
 Neoplasms, Experimental Antibodies  >1 publications with ATP2A1 and Neoplasms, Experimental
 Abnormalities, Drug-Induced Antibodies  >1 publications with ATP2A1 and Abnormalities, Drug-Induced
 Kidney Diseases Antibodies  >1 publications with ATP2A1 and Kidney Diseases
 Liver Diseases Antibodies  >1 publications with ATP2A1 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >104 publications with ATP2A1 and Muscle
 Heart Antibodies  >25 publications with ATP2A1 and Heart
 Nerve Antibodies  >8 publications with ATP2A1 and Nerve
 Brain Antibodies  >6 publications with ATP2A1 and Brain
 Embryonic Tissue Antibodies  >6 publications with ATP2A1 and Embryonic Tissue
 Lung Antibodies  >5 publications with ATP2A1 and Lung
 Thyroid Antibodies  >3 publications with ATP2A1 and Thyroid
 Prostate Antibodies  >2 publications with ATP2A1 and Prostate
 Eye Antibodies  >2 publications with ATP2A1 and Eye
 Liver Antibodies  >2 publications with ATP2A1 and Liver
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