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anti-SET antibody :: Rabbit SET nuclear oncogene Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS714835 anti-SET antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SET nuclear oncogene, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human SET nuclear oncogene polyclonal Antibody

 Product Synonym Names    SET nuclear oncogene; SET; 2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII; TAF-I; TAF-IBETA
 Product Gene Name   

anti-SET antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600960
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human SET
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-5655 / sc-27269 / sc-25564
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-SET antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SET antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for SET. It may not necessarily be applicable to this product.
 NCBI GI #    21618461
 NCBI GeneID    6418
 NCBI Accession #    AAH32749.1 [Other Products]
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 UniProt Secondary Accession #    Q15541; Q5VXV1; Q5VXV2; Q6FHZ5; A5A5H4; A6NGV1; B4DUE2 [Other Products]
 UniProt Related Accession #    Q01105 [Other Products]
 Molecular Weight    31,404 Da [Similar Products]
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 NCBI Official Full Name    SET nuclear oncogene
 NCBI Official Synonym Full Names    SET nuclear proto-oncogene
 NCBI Official Symbol    SET [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    protein SET; SET nuclear oncogene; HLA-DR-associated protein II; phosphatase 2A inhibitor I2PP2A; inhibitor-2 of protein phosphatase-2A; protein phosphatase type 2A inhibitor; inhibitor of granzyme A-activated DNase; SET translocation (myeloid leukemia-associated); Template-Activating Factor-I, chromatin remodelling factor
 UniProt Protein Name    Protein SET
 UniProt Synonym Protein Names   
HLA-DR-associated protein II; Inhibitor of granzyme A-activated DNase; IGAAD; PHAPII; Phosphatase 2A inhibitor I2PP2A; I-2PP2A; Template-activating factor I; TAF-I
 Protein Family    Protein
 UniProt Gene Name    SET [Similar Products]
 UniProt Synonym Gene Names    IGAAD; I-2PP2A; TAF-I [Similar Products]
 UniProt Entry Name    SET_HUMAN
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 NCBI Summary for SET    The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
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 UniProt Comments for SET    SET: a potent inhibitor of protein phosphatase 2A involved in apoptosis, transcription, nucleosome assembly and histone binding. The translocation t(6;9)(q21;q34.1) NUP214/CAN is found in some cases of acute undifferentiated leukemia (AUL). Two alternatively spliced isoforms have been described. Isoform 1 and isoform 2 interact directly with each other and with ANP32A within the tripartite INHAT (inhibitor of acetyltransferases) complex. Both isoforms inhibit the acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition.

Protein type: Apoptosis; Inhibitor; DNA replication; Oncoprotein; Nuclear receptor co-regulator; DNA-binding

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: nucleoplasm; protein complex; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm; cytosol; nucleus

Molecular Function: protein binding; DNA binding; histone binding; protein phosphatase type 2A regulator activity; protein phosphatase inhibitor activity

Biological Process: nucleosome assembly; nucleosome disassembly; regulation of catalytic activity; negative regulation of catalytic activity; gene expression; nucleocytoplasmic transport; negative regulation of neuron apoptosis; mitotic cell cycle; negative regulation of transcription, DNA-dependent; DNA replication; negative regulation of histone acetylation
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 Research Articles on SET    1. SET/TAF-Ibeta inhibits FoxO1 acetylation and activates its transcriptional activity toward p21
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SET antibodyPathways associated with anti-SET antibody
 Reference Product  PubMed Publications
 NUP214 antibody  >28 publications with SET and NUP214
 NME1 antibody  >22 publications with SET and NME1
 ANP32A antibody  >17 publications with SET and ANP32A
 APEX1 antibody  >14 publications with SET and APEX1
 ELAVL1 antibody  >10 publications with SET and ELAVL1
 TNFSF13 antibody  >8 publications with SET and TNFSF13
 XPO1 antibody  >4 publications with SET and XPO1
 USP46 antibody  >1 publications with SET and USP46
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Condensation Of Prophase Chromosomes Pathway antibodies  Condensation Of Prophase Chromosomes Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 HuR Stabilizes MRNA Pathway antibodies  HuR Stabilizes MRNA Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Prophase Pathway antibodies  Mitotic Prophase Pathway Diagram
 Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway antibodies  Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway Diagram
Diseases associated with anti-SET antibodyOrgans/Tissues associated with anti-SET antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >21017 publications with SET and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >13548 publications with SET and Cardiovascular Diseases
 Immune System Diseases Antibodies  >10210 publications with SET and Immune System Diseases
 Inflammation Antibodies  >4412 publications with SET and Inflammation
 Breast Neoplasms Antibodies  >4373 publications with SET and Breast Neoplasms
 Disease Models, Animal Antibodies  >3926 publications with SET and Disease Models, Animal
 Liver Diseases Antibodies  >3343 publications with SET and Liver Diseases
 Hypertension Antibodies  >3307 publications with SET and Hypertension
 Adenocarcinoma Antibodies  >3127 publications with SET and Adenocarcinoma
 Kidney Diseases Antibodies  >2811 publications with SET and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >35449 publications with SET and Blood
 Brain Antibodies  >23196 publications with SET and Brain
 Heart Antibodies  >11997 publications with SET and Heart
 Muscle Antibodies  >10665 publications with SET and Muscle
 Bone Antibodies  >10330 publications with SET and Bone
 Vascular Antibodies  >8354 publications with SET and Vascular
 Lung Antibodies  >7573 publications with SET and Lung
 Liver Antibodies  >7375 publications with SET and Liver
 Skin Antibodies  >6568 publications with SET and Skin
 Eye Antibodies  >6151 publications with SET and Eye
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