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anti-SETDB2 antibody :: Goat SETDB2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422716
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SETDB2, Polyclonal Antibody

 Also Known As   

Goat anti-SETDB2 Antibody

 Product Synonym Names    Goat Anti-CLLD8 / SETDB2 Antibody; SETDB2; SET domain, bifurcated 2; C13orf4; CLLD8; CLLL8; DKFZp586I0123; DKFZp761J1217; KMT1F; OTTHUMP00000018418; chronic lymphocytic leukemia deletion region 8; chronic lymphocytic leukemia deletion region gene 8 protein; histone-lysine N-methyltransfera; SETDB2 antibody; SET domain; bifurcated 2 antibody; C13orf4 antibody; CLLD8 antibody; CLLL8 antibody; DKFZp586I0123 antibody; DKFZp761J1217 antibody; KMT1F antibody; OTTHUMP00000018418 antibody; chronic lymphocytic leukemia deletion region gene 8 protein antibody; histone-lysine N-methyltransfera antibody
 Product Gene Name   

anti-SETDB2 antibody

[Similar Products]
 Antibody/Peptide Pairs    SETDB2 peptide (MBS427400) is used for blocking the activity of SETDB2 antibody (MBS422716)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    QRRHAKTNSH SSALH
 OMIM    607865
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Dog, Pig, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-QRRHAKTNSHSSALH, from the internal region of the protein sequence according to NP_114121.2; NP_001153780.1.
 Epitope    Internal region
 Note    This antibody is expected to recognize both reported isoforms (NP_114121.2; NP_001153780.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-SETDB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SETDB2 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-SETDB2 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 90kDa band observed in Human Heart lysates (calculated MW of 81.9kDa according to NP_114121.2). Recommended concentration: 0.1-0.3ug/ml.
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 Western Blot (WB) of anti-SETDB2 antibody    (0.1ug/ml) staining of Human Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-SETDB2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SETDB2. It may not necessarily be applicable to this product.
 NCBI GI #    238624095
 NCBI GeneID    83852
 NCBI Accession #    NP_114121.2 [Other Products]
 NCBI Related Accession #    NP_001153780.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_031915.2 [Other Products]
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 UniProt Secondary Accession #    Q5TC65; Q5TC66; Q5W0A7; Q659A7; Q86UD6; Q96AI6 [Other Products]
 UniProt Related Accession #    Q96T68 [Other Products]
 Molecular Weight    81,766 Da
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 NCBI Official Full Name    histone-lysine N-methyltransferase SETDB2 isoform a
 NCBI Official Synonym Full Names    SET domain bifurcated 2
 NCBI Official Symbol    SETDB2 [Similar Products]
 NCBI Official Synonym Symbols   
CLLD8; CLLL8; KMT1F; C13orf4
[Similar Products]
 NCBI Protein Information    histone-lysine N-methyltransferase SETDB2
 UniProt Protein Name    Histone-lysine N-methyltransferase SETDB2
 UniProt Synonym Protein Names   
Chronic lymphocytic leukemia deletion region gene 8 protein; Lysine N-methyltransferase 1F; SET domain bifurcated 2
 Protein Family    Histone-lysine N-methyltransferase
 UniProt Gene Name    SETDB2 [Similar Products]
 UniProt Synonym Gene Names    C13orf4; CLLD8; KMT1F [Similar Products]
 UniProt Entry Name    SETB2_HUMAN
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 NCBI Summary for SETDB2    This gene encodes a member of a family of proteins that contain a methyl-CpG-binding domain (MBD) and a SET domain and function as histone methyltransferases. This protein is recruited to heterochromatin and plays a role in the regulation of chromosome segregation. This region is commonly deleted in chronic lymphocytic leukemia. Naturally-occuring readthrough transcription occurs from this gene to the downstream PHF11 (PHD finger protein 11) gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
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 UniProt Comments for SETDB2    SETDB2: Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. Belongs to the histone-lysine methyltransferase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase, protein lysine; Methyltransferase

Chromosomal Location of Human Ortholog: 13q14

Cellular Component: chromosome; nucleoplasm; nucleus

Molecular Function: DNA binding; histone lysine N-methyltransferase activity (H3-K9 specific); histone-lysine N-methyltransferase activity; protein binding; zinc ion binding

Biological Process: cell division; chromosome segregation; heart looping; histone H3-K9 methylation; mitosis; negative regulation of transcription, DNA-dependent
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 Research Articles on SETDB2    1. these findings identify Setdb2 as a novel regulator of the immune system in acute respiratory viral infection.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-SETDB2 antibodyDiseases associated with anti-SETDB2 antibody
 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 PKMTs Methylate Histone Lysines Pathway antibodies  PKMTs Methylate Histone Lysines Pathway Diagram
 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >3 publications with SETDB2 and Lung Diseases
 Stomach Neoplasms Antibodies  >1 publications with SETDB2 and Stomach Neoplasms
 Leukemia Antibodies  >1 publications with SETDB2 and Leukemia
 Chromosome Aberrations Antibodies  >1 publications with SETDB2 and Chromosome Aberrations
 Breast Neoplasms Antibodies  >1 publications with SETDB2 and Breast Neoplasms
 Inflammation Antibodies  >1 publications with SETDB2 and Inflammation
Organs/Tissues associated with anti-SETDB2 antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >3 publications with SETDB2 and Lung
 Blood Antibodies  >2 publications with SETDB2 and Blood
 Heart Antibodies  >2 publications with SETDB2 and Heart
 Testis Antibodies  >1 publications with SETDB2 and Testis
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