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anti-SGK1 antibody :: Rabbit SGK1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151408
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SGK1, Polyclonal Antibody

 Also Known As   

SGK1 Antibody

 Product Synonym Names    SGK1; SGK; SGK; serum/glucocorticoid regulated kinase 1
 Product Gene Name   

anti-SGK1 antibody

[Similar Products]
 Antibody/Peptide Pairs    SGK1 peptide (MBS151965) is used for blocking the activity of SGK1 antibody (MBS151408)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602958
 3D Structure    ModBase 3D Structure for O00141
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    SGK1 antibody is predicted to not cross-react with other SGK protein family members. At least five isoforms are known to exist
 Purity/Purification    SGK1 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    SGK1 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human SGK1.
 Buffer    SGK1 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    SGK1 antibody can be stored at 4 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-SGK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SGK1 antibody

   SGK1 Antibody: Serum and glucocorticoid-regulated protein kinase 1 (SGK1) is a member of the AGC family of serine/threonine kinases that plays an important role in cellular stress response and cell survival. SGK1 is transcriptionally activated by numerous stimuli, including serum, glucocorticoids, osmotic stress, and hormones. SGK1 functions as a regulator of cell survival and ion channels and transporters such as ENaC or KCNA3/Kv1.3. It phosphorylates and negatively regulates pro-apoptotic FOXO3A. SGK1 is thought to play an essential function in nephropathy and cardiovascular development.
 Applications Tested/Suitable for anti-SGK1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-SGK1 antibody    SGK1 antibody can be used for detection of SGK1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-SGK1 antibody    Western blot analysis of SGK1 in human stomach tissue lysate with SGK1 antibody at (A) 1 and (B) 2 μg/mL.
anti-SGK1 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-SGK1 antibody    Immunofluorescence of SGK1 in human stomach tissue with SGK1 antibody at 20 μg/mL.
anti-SGK1 antibody Immunofluorescence (IF) image
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 Immunohistochemistry (IHC) of anti-SGK1 antibody    Immunohistochemistry of SGK1 in human stomach tissue with SGK1 antibody at 5 μg/mL.
anti-SGK1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for SGK1. It may not necessarily be applicable to this product.
 NCBI GI #    25168263
 NCBI GeneID    6446
 NCBI Accession #    NP_005618 [Other Products]
 NCBI GenBank Nucleotide #    NM_005627.3 [Other Products]
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 UniProt Primary Accession #    O00141 [Other Products]
 UniProt Secondary Accession #    Q5TCN2; Q5TCN3; Q5TCN4; Q5VY65; Q9UN56; B7UUP7; B7UUP8; B7UUP9; B7Z5B2; E1P583 [Other Products]
 UniProt Related Accession #    O00141 [Other Products]
 Molecular Weight    52,119 Da
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 NCBI Official Full Name    serine/threonine-protein kinase Sgk1 isoform 1
 NCBI Official Synonym Full Names    serum/glucocorticoid regulated kinase 1
 NCBI Official Symbol    SGK1 [Similar Products]
 NCBI Official Synonym Symbols   
SGK
[Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase Sgk1; Sgk1 variant i3; serine/threonine protein kinase SGK; serum/glucocorticoid-regulated kinase 1
 UniProt Protein Name    Serine/threonine-protein kinase Sgk1
 UniProt Synonym Protein Names   
Serum/glucocorticoid-regulated kinase 1
 Protein Family    Serine/threonine-protein kinase
 UniProt Gene Name    SGK1 [Similar Products]
 UniProt Synonym Gene Names    SGK [Similar Products]
 UniProt Entry Name    SGK1_HUMAN
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 NCBI Summary for SGK1    This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
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 UniProt Comments for SGK1    SGK1: serum and glucocorticoid-inducible kinase is an AGC protein kinase of the SGK family. Rapidly induced in response to a variety of stimuli including serum, glucocorticoids, follicle stimulating hormone, osmotic shock and mineralocorticoids. Can be activated via PI3K-dependent and -independent pathways. Plays a role in activating certain potassium, sodium and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. SGK is negatively regulated by ubiquitin modification and proteasome degradation.

Protein type: Protein kinase, AGC; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis; AGC group; SGK family

Chromosomal Location of Human Ortholog: 6q23

Cellular Component: nucleoplasm; endoplasmic reticulum membrane; mitochondrion; cytoplasm; plasma membrane; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; potassium channel regulator activity; chloride channel regulator activity; sodium channel regulator activity; calcium channel regulator activity; protein serine/threonine/tyrosine kinase activity; ATP binding

Biological Process: apoptosis; positive regulation of transporter activity; sodium ion transport; protein amino acid phosphorylation; regulation of cell migration; regulation of cell proliferation; regulation of apoptosis; regulation of transcription factor activity; long-term memory; regulation of catalytic activity; regulation of blood pressure; response to stress; regulation of cell growth; response to DNA damage stimulus; transmembrane transport
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 Research Articles on SGK1    1. The role of distinct SGK1/FOXO3A-associated regulation in p53 versus ANXA7 responses were elucidated and proposed that aberrant SGK1 could affect reciprocal SGK1-FOXO3A-Akt regulation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-SGK1 antibodyDiseases associated with anti-SGK1 antibody
 Products by Pathway  Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Class I PI3K Signaling Events Pathway antibodies  Class I PI3K Signaling Events Pathway Diagram
 FSH Signaling Pathway antibodies  FSH Signaling Pathway Diagram
 FoxO Family Signaling Pathway antibodies  FoxO Family Signaling Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 IL-6 Signaling Pathway antibodies  IL-6 Signaling Pathway Diagram
 Insulin Pathway antibodies  Insulin Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >80 publications with SGK1 and Hypertension
 Cardiovascular Diseases Antibodies  >52 publications with SGK1 and Cardiovascular Diseases
 Fibrosis Antibodies  >49 publications with SGK1 and Fibrosis
 Kidney Diseases Antibodies  >47 publications with SGK1 and Kidney Diseases
 Inflammation Antibodies  >34 publications with SGK1 and Inflammation
 Nervous System Diseases Antibodies  >25 publications with SGK1 and Nervous System Diseases
 Proteinuria Antibodies  >19 publications with SGK1 and Proteinuria
 Brain Diseases Antibodies  >14 publications with SGK1 and Brain Diseases
 Heart Diseases Antibodies  >13 publications with SGK1 and Heart Diseases
 Carcinoma Antibodies  >13 publications with SGK1 and Carcinoma
Organs/Tissues associated with anti-SGK1 antibody
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >206 publications with SGK1 and Kidney
 Blood Antibodies  >153 publications with SGK1 and Blood
 Brain Antibodies  >46 publications with SGK1 and Brain
 Heart Antibodies  >41 publications with SGK1 and Heart
 Lung Antibodies  >40 publications with SGK1 and Lung
 Muscle Antibodies  >40 publications with SGK1 and Muscle
 Intestine Antibodies  >23 publications with SGK1 and Intestine
 Liver Antibodies  >21 publications with SGK1 and Liver
 Vascular Antibodies  >20 publications with SGK1 and Vascular
 Bone Antibodies  >17 publications with SGK1 and Bone
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