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anti-SGK1 antibody :: Rabbit SGK1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2534703
Western Blot (WB)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SGK1, Polyclonal Antibody

★Popular Item★
 Also Known As   

SGK1 Polyclonal Antibody

 Product Synonym Names    SGK1; SGK; Serine/threonine-protein kinase Sgk1; Serum/glucocorticoid-regulated kinase 1
 Product Gene Name   

anti-SGK1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602958
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/mL (lot specific)
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 Immunogen    Synthesized peptide derived from human SGK1 around the non-phosphorylation site of S78.
 Buffer    PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH 7.4
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 Preparation and Storage    Store at -20C. Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-SGK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-SGK1 antibody

   Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, KCNA3/Kv1.3 or EAAT1. Isoform 2 exhibited a greater effect on cell plasma membrane expression of ENaC and Na(+) transport than isoform 1.
 Product Categories/Family for anti-SGK1 antibody    Stem cells
 Applications Tested/Suitable for anti-SGK1 antibody   

Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-SGK1 antibody    WB: 1:500-1:2000
IHC: 1:100-1:300
IF: 1:200-1:1000
ELISA: 1:5000
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 Western Blot (WB) of anti-SGK1 antibody    Western Blot analysis of HuvEc cells using SGK1 Polyclonal Antibody
anti-SGK1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SGK1. It may not necessarily be applicable to this product.
 NCBI GI #    219521880
 NCBI GeneID    6446
 NCBI Accession #    NP_001137150.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001143678.1 [Other Products]
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 UniProt Secondary Accession #    Q5TCN2; Q5TCN3; Q5TCN4; Q5VY65; Q9UN56; B7UUP7; B7UUP8; B7UUP9; B7Z5B2; E1P583 [Other Products]
 UniProt Related Accession #    O00141 [Other Products]
 Molecular Weight    Calculated MW: 49
Observed MW: 54
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 NCBI Official Full Name    serine/threonine-protein kinase Sgk1 isoform 4
 NCBI Official Synonym Full Names    serum/glucocorticoid regulated kinase 1
 NCBI Official Symbol    SGK1 [Similar Products]
 NCBI Official Synonym Symbols   
SGK
[Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase Sgk1
 UniProt Protein Name    Serine/threonine-protein kinase Sgk1
 UniProt Synonym Protein Names   
Serum/glucocorticoid-regulated kinase 1
 Protein Family    Serine/threonine-protein kinase
 UniProt Gene Name    SGK1 [Similar Products]
 UniProt Synonym Gene Names    SGK [Similar Products]
 UniProt Entry Name    SGK1_HUMAN
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 NCBI Summary for SGK1    This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
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 UniProt Comments for SGK1    SGK1: serum and glucocorticoid-inducible kinase is an AGC protein kinase of the SGK family. Rapidly induced in response to a variety of stimuli including serum, glucocorticoids, follicle stimulating hormone, osmotic shock and mineralocorticoids. Can be activated via PI3K-dependent and -independent pathways. Plays a role in activating certain potassium, sodium and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. SGK is negatively regulated by ubiquitin modification and proteasome degradation.

Protein type: Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; AGC group; SGK family

Chromosomal Location of Human Ortholog: 6q23

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum membrane; mitochondrion; neuron projection; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane

Molecular Function: 3-phosphoinositide-dependent protein kinase binding; ATP binding; calcium channel regulator activity; chloride channel regulator activity; cofactor binding; potassium channel regulator activity; protein binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; sodium channel regulator activity; tau protein binding

Biological Process: apoptosis; cellular sodium ion homeostasis; glucocorticoid mediated signaling; long-term memory; microtubule depolymerization; negative regulation of apoptosis; negative regulation of microtubule polymerization; neurite morphogenesis; peptidyl-serine phosphorylation; positive regulation of cell growth; positive regulation of dendrite morphogenesis; positive regulation of transporter activity; protein amino acid phosphorylation; regulation of apoptosis; regulation of blood pressure; regulation of catalytic activity; regulation of cell cycle; regulation of cell growth; regulation of cell migration; regulation of cell proliferation; regulation of transcription factor activity; response to DNA damage stimulus; response to stress; sodium ion transport; transmembrane transport; visual learning
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 Research Articles on SGK1    1. SGK1 inhibits intestinal epithelial cell apoptosis and promotes proliferation via the MEK/ERK/p53 pathway in colitis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SGK1 antibodyPathways associated with anti-SGK1 antibody
 Reference Product  PubMed Publications
 MTOR antibody  >46 publications with SGK1 and MTOR
 RICTOR antibody  >15 publications with SGK1 and RICTOR
 KCNJ1 antibody  >12 publications with SGK1 and KCNJ1
 FOXO3 antibody  >10 publications with SGK1 and FOXO3
 PDPK1 antibody  >10 publications with SGK1 and PDPK1
 FOXO1 antibody  >9 publications with SGK1 and FOXO1
 NEDD4L antibody  >3 publications with SGK1 and NEDD4L
 SLC9A3R2 antibody  >2 publications with SGK1 and SLC9A3R2
 UBC antibody  >1 publications with SGK1 and UBC
 Products by Pathway  Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Class I PI3K Signaling Events Pathway antibodies  Class I PI3K Signaling Events Pathway Diagram
 FSH Signaling Pathway antibodies  FSH Signaling Pathway Diagram
 FoxO Family Signaling Pathway antibodies  FoxO Family Signaling Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 IL-6 Signaling Pathway antibodies  IL-6 Signaling Pathway Diagram
 Insulin Pathway antibodies  Insulin Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
Diseases associated with anti-SGK1 antibodyOrgans/Tissues associated with anti-SGK1 antibody
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >90 publications with SGK1 and Hypertension
 Cardiovascular Diseases Antibodies  >62 publications with SGK1 and Cardiovascular Diseases
 Fibrosis Antibodies  >53 publications with SGK1 and Fibrosis
 Kidney Diseases Antibodies  >48 publications with SGK1 and Kidney Diseases
 Inflammation Antibodies  >45 publications with SGK1 and Inflammation
 Disease Models, Animal Antibodies  >41 publications with SGK1 and Disease Models, Animal
 Nervous System Diseases Antibodies  >30 publications with SGK1 and Nervous System Diseases
 Lung Diseases Antibodies  >22 publications with SGK1 and Lung Diseases
 Proteinuria Antibodies  >19 publications with SGK1 and Proteinuria
 Carcinoma Antibodies  >19 publications with SGK1 and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >217 publications with SGK1 and Kidney
 Blood Antibodies  >181 publications with SGK1 and Blood
 Brain Antibodies  >61 publications with SGK1 and Brain
 Heart Antibodies  >49 publications with SGK1 and Heart
 Muscle Antibodies  >47 publications with SGK1 and Muscle
 Lung Antibodies  >46 publications with SGK1 and Lung
 Vascular Antibodies  >30 publications with SGK1 and Vascular
 Intestine Antibodies  >27 publications with SGK1 and Intestine
 Liver Antibodies  >23 publications with SGK1 and Liver
 Nerve Antibodies  >21 publications with SGK1 and Nerve
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