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anti-SH2D1A antibody :: Goat SH2D1A/SLAM associated protein Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421463
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SH2D1A/SLAM associated protein, Polyclonal Antibody

 Also Known As   

Goat anti-SH2D1A/SLAM associated protein Antibody

 Product Synonym Names    Goat Anti-SH2D1A / SAP Antibody; SH2D1A; SH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome); HGNC: 10820; DSHP; EBVS; IMD5; LYP; MTCP1; SAP; XLP; XLPD; SH2 domain protein 1A; SLAM (signaling lymphocyte activation molecule) associated protein; T cell signal transduction; SH2D1A antibody; SH2 domain protein 1A; Duncan\1s disease (lymphoproliferative syndrome) antibody; HGNC: 10820 antibody; DSHP antibody; EBVS antibody; IMD5 antibody; LYP antibody; MTCP1 antibody; SAP antibody; XLP antibody; XLPD antibody; SH2 domain protein 1A antibody; SLAM (signaling lymphocyte activation molecule) associated protein antibody; T cell signal transduction molecule SAP antibody; RP5-1052M9.3 antibody; FLJ18687 antibody; FLJ92177 antibody; Duncan's disease (lymphoproliferative syndrome) antibody; Duncan's disease antibody; SLAM-associated protein antibody; T cell signal transduction molecule SAP; signaling lymphocyte activation molecule-associated protein antibody; SH2D1A/SLAM associated protein
 Product Gene Name   

anti-SH2D1A antibody

[Similar Products]
 Product Synonym Gene Name    SLAM [Similar Products]
 Antibody/Peptide Pairs    SH2D1A/SLAM associated protein peptide (MBS425080) is used for blocking the activity of SH2D1A/SLAM associated protein antibody (MBS421463)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    QYPVEKKSSA RSTQ
 OMIM    300490
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Pig,
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-QYPVEKKSSARSTQ, from the internal region of the protein sequence according to NP_002342.1; NP_001108409.1.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-SH2D1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SH2D1A antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-SH2D1A antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 16kDa band observed in Human Lymph Node lysates (calculated MW of 14.2kDa according to NP_002342.1). In transfected HEK293 transiently expressing SH2D1A a band of approx.17kDa is observed. This band is not observed in the non-transfected HEK293. Recommended concentration: 0.2-0.6ug/ml.
Immunoprecipitation: This antibody was deemed fit for IP under native conditions (observations from anonymous customer).
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 Western Blot (WB) of anti-SH2D1A antibody    (0.2ug/ml) staining of human lymph node lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-SH2D1A antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-SH2D1A antibody    HEK293 overexpressing SH2D1A (RC204723) and probed (mock transfection in first lane), tested by Origene.
anti-SH2D1A antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SH2D1A. It may not necessarily be applicable to this product.
 NCBI GI #    4506923
 NCBI GeneID    4068
 NCBI Accession #    NP_002342.1 [Other Products]
 NCBI Related Accession #    NP_001108409.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002351.4 [Other Products]
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 UniProt Secondary Accession #    O95383; O95384; O95385; O95386; Q6FGS6; Q9UNR0; A8MSW0 [Other Products]
 UniProt Related Accession #    O60880 [Other Products]
 Molecular Weight    6,631 Da
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 NCBI Official Full Name    SH2 domain-containing protein 1A isoform 1
 NCBI Official Synonym Full Names    SH2 domain containing 1A
 NCBI Official Symbol    SH2D1A [Similar Products]
 NCBI Official Synonym Symbols   
LYP; SAP; XLP; DSHP; EBVS; IMD5; XLPD; MTCP1; XLPD1; SAP/SH2D1A
[Similar Products]
 NCBI Protein Information    SH2 domain-containing protein 1A
 UniProt Protein Name    SH2 domain-containing protein 1A
 UniProt Synonym Protein Names   
Duncan disease SH2-protein; Signaling lymphocytic activation molecule-associated protein; SLAM-associated protein; T-cell signal transduction molecule SAP
 Protein Family    SH2 domain-containing protein
 UniProt Gene Name    SH2D1A [Similar Products]
 UniProt Synonym Gene Names    DSHP; SAP; SLAM-associated protein [Similar Products]
 UniProt Entry Name    SH21A_HUMAN
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 NCBI Summary for SH2D1A    This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SH2D1A    SH2D1A: Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3. Interacts with NTRK1, NTRK2 and NTRK3. Interacts with CD84, CD244, LY9, SLAMF1 and FYN. Expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: Xq25

Cellular Component: cytoplasm; cytosol

Molecular Function: protein binding; SH3/SH2 adaptor activity

Biological Process: adaptive immune response; cell-cell signaling; cellular defense response; humoral immune response; innate immune response; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of signal transduction; regulation of immune response

Disease: Lymphoproliferative Syndrome, X-linked, 1
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 Research Articles on SH2D1A    1. The mutation c.131G>A in this patient was found in combination with a second SH2D1A mutation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SH2D1A antibodyPathways associated with anti-SH2D1A antibody
 Reference Product  PubMed Publications
 CD244 antibody  >49 publications with SH2D1A and CD244
 FYN antibody  >39 publications with SH2D1A and FYN
 SLAMF1 antibody  >22 publications with SH2D1A and SLAMF1
 CD84 antibody  >19 publications with SH2D1A and CD84
 LY9 antibody  >16 publications with SH2D1A and LY9
 CD40 antibody  >15 publications with SH2D1A and CD40
 SLAMF6 antibody  >14 publications with SH2D1A and SLAMF6
 FYB antibody  >1 publications with SH2D1A and FYB
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram
 Measles Pathway antibodies  Measles Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
Diseases associated with anti-SH2D1A antibodyOrgans/Tissues associated with anti-SH2D1A antibody
 Disease Name  Pubmed Publications
 Lymphoproliferative Disorders Antibodies  >191 publications with SH2D1A and Lymphoproliferative Disorders
 Nervous System Diseases Antibodies  >14 publications with SH2D1A and Nervous System Diseases
 Necrosis Antibodies  >7 publications with SH2D1A and Necrosis
 Inflammation Antibodies  >7 publications with SH2D1A and Inflammation
 Vascular Diseases Antibodies  >5 publications with SH2D1A and Vascular Diseases
 Cardiovascular Diseases Antibodies  >5 publications with SH2D1A and Cardiovascular Diseases
 Lung Diseases Antibodies  >5 publications with SH2D1A and Lung Diseases
 Prostatic Neoplasms Antibodies  >2 publications with SH2D1A and Prostatic Neoplasms
 Liver Neoplasms Antibodies  >1 publications with SH2D1A and Liver Neoplasms
 Breast Neoplasms Antibodies  >1 publications with SH2D1A and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >250 publications with SH2D1A and Blood
 Bone Marrow Antibodies  >25 publications with SH2D1A and Bone Marrow
 Thymus Antibodies  >14 publications with SH2D1A and Thymus
 Liver Antibodies  >8 publications with SH2D1A and Liver
 Spleen Antibodies  >8 publications with SH2D1A and Spleen
 Lung Antibodies  >4 publications with SH2D1A and Lung
 Prostate Antibodies  >2 publications with SH2D1A and Prostate
 Pharynx Antibodies  >2 publications with SH2D1A and Pharynx
 Testis Antibodies  >1 publications with SH2D1A and Testis
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