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anti-SHC3 antibody :: Rabbit anti-Human SHC-Transforming Protein 3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2027238 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.02 mg  /  $130 +1 FREE 8GB USB
0.05 mg  /  $175 +1 FREE 8GB USB
0.1 mg  /  $225 +1 FREE 8GB USB
0.2 mg  /  $340 +1 FREE 8GB USB
1 mg  /  $800 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SHC-Transforming Protein 3 (SHC3), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to SHC-Transforming Protein 3 (SHC3)

 Product Gene Name   

anti-SHC3 antibody

[Similar Products]
 Matching Pairs    Antibody: SHC-Transforming Protein 3 (MBS2027238)
Antigen: SHC-Transforming Protein 3 (MBS2030912)
 Matching Pairs    Unconjugated Antibody: SHC-Transforming Protein 3 (MBS2027238)
APC: SHC-Transforming Protein 3 (SHC3) (MBS2074953)
 Matching Pairs    Unconjugated Antibody: SHC-Transforming Protein 3 (MBS2027238)
PE Conjugated Antibody: SHC-Transforming Protein 3 (SHC3) (MBS2074954)
 Matching Pairs    Unconjugated Antibody: SHC-Transforming Protein 3 (MBS2027238)
APC: SHC-Transforming Protein 3 (SHC3) (MBS2074955)
 Matching Pairs    Unconjugated Antibody: SHC-Transforming Protein 3 (MBS2027238)
Cy3 Conjugated Antibody: SHC-Transforming Protein 3 (SHC3) (MBS2074956)
 Matching Pairs    Unconjugated Antibody: SHC-Transforming Protein 3 (MBS2027238)
FITC Conjugated Antibody: SHC-Transforming Protein 3 (SHC3) (MBS2074957)
 Matching Pairs    Unconjugated Antibody: SHC-Transforming Protein 3 (MBS2027238)
HRP Conjugated Antibody: SHC-Transforming Protein 3 (SHC3) (MBS2074958)
 Matching Pairs    Unconjugated Antibody: SHC-Transforming Protein 3 (MBS2027238)
APC: Immunoglobulin G (MBS2090675)
 Matching Pairs    Unconjugated Antibody: SHC-Transforming Protein 3 (MBS2027238)
Unconjugated Secondary Antibody: Immunoglobulin G (MBS2090678)
 Matching Pairs    Unconjugated Antibody: SHC-Transforming Protein 3 (MBS2027238)
Biotin Conjugated Antibody: SHC-Transforming Protein 3 (SHC3) (MBS2095782)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    D84361 mRNA
 3D Structure    ModBase 3D Structure for Q92529
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is a rabbit polyclonal antibody raised against SHC3. It has beenselected for its ability to recognize SHC3 in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Liquid
 Concentration    200ug/ml (lot specific)
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 Fragment    SHC3 (Val188~Gln433)
 Organism Species    Homo sapiens (Human)
 Conjugate    No Conjugate
 Immunogen    Recombinant SHC3 (Val188~Gln433) expressed in E Coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2074955
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-SHC3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-SHC3 antibody    Knock-Out Validation Antibody
 Applications Tested/Suitable for anti-SHC3 antibody   

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)

 Application Notes for anti-SHC3 antibody    Western blotting: 0.5-2ug/ml
Immunocytochemistry in formalin fixed cells: 5-20ug/ml
Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml
Immunohistochemistry in paraffin section: 5-20ug/ml
Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml
Optimal working dilutions must be determined by end user.
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 Western Blot (WB) Knockout Verification of anti-SHC3 antibody    Knockout Verification: Lane 1: Wild-type HepG2 cell lysate; Lane 2: SHC3 knockout HepG2 cell lysate; Predicted MW: 64,51kd Observed MW: 51kd Primary Ab: 3ug/ml Rabbit Anti-Human SHC3 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
anti-SHC3 antibody Western Blot (WB) Knockout Verification (WB) image
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 Western Blot (WB) of anti-SHC3 antibody    Western Blot; Sample: Lane1: Porcine Brain Tissue; Lane2: Human HepG2 Cells.
anti-SHC3 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-SHC3 antibody    Western Blot; Sample: Recombinant SHC3, Human.
anti-SHC3 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-SHC3 antibody    DAB staining on IHC-P; Samples: Human Stomach Cancer Tissue.
anti-SHC3 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-SHC3 antibody    DAB staining on IHC-P; Samples: Human Liver Tissue
anti-SHC3 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-SHC3 antibody    DAB staining on IHC-P; Samples: Human Kidney Tissue
anti-SHC3 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for SHC3. It may not necessarily be applicable to this product.
 NCBI GI #    224586793
 NCBI GeneID    53358
 NCBI Accession #    NP_058544.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_016848.5 [Other Products]
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 UniProt Primary Accession #    Q92529 [Other Products]
 UniProt Secondary Accession #    Q5T7I7; Q8TAP2; Q9UCX5 [Other Products]
 UniProt Related Accession #    Q92529 [Other Products]
 Molecular Weight    51,939 Da
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 NCBI Official Full Name    SHC-transforming protein 3
 NCBI Official Synonym Full Names    SHC adaptor protein 3
 NCBI Official Symbol    SHC3 [Similar Products]
 NCBI Official Synonym Symbols   
RAI; NSHC; SHCC; N-Shc
[Similar Products]
 NCBI Protein Information    SHC-transforming protein 3
 UniProt Protein Name    SHC-transforming protein 3
 UniProt Synonym Protein Names   
Neuronal Shc; N-Shc; Protein Rai; SHC-transforming protein C; Src homology 2 domain-containing-transforming protein C3; SH2 domain protein C3
 Protein Family    SHC-transforming protein
 UniProt Gene Name    SHC3 [Similar Products]
 UniProt Synonym Gene Names    NSHC; SHCC; N-Shc; SH2 domain protein C3 [Similar Products]
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 UniProt Comments for SHC3    SHC3: an adapter protein containing an SH2 and a PID domain. Couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons and the regulation of NMDA receptor function in the hippocampus. May modulate hippocampal synaptic plasticity underlying learning and memory. Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors. Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord. A switch from Shc1 to Shc3 occurs during maturation of neuronal precursors to postmitotic neurons. Two alternatively spliced isoforms have been described.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9q22.1

Cellular Component: cytosol; plasma membrane

Molecular Function: phosphotyrosine binding; protein binding; Ras guanyl-nucleotide exchange factor activity; receptor tyrosine kinase binding; signal transducer activity

Biological Process: axon guidance; central nervous system development; epidermal growth factor receptor signaling pathway; learning and/or memory; MAPK cascade; Ras protein signal transduction; regulation of molecular function; synaptic transmission, glutamatergic; transmembrane receptor protein tyrosine kinase signaling pathway
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 Research Articles on SHC3    1. High SHC3 expression is associated with glioblastoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SHC3 antibodyPathways associated with anti-SHC3 antibody
 Reference Product  PubMed Publications
 NTRK1 antibody  >6 publications with SHC3 and NTRK1
 GRB2 antibody  >5 publications with SHC3 and GRB2
 RET antibody  >4 publications with SHC3 and RET
 NTRK2 antibody  >4 publications with SHC3 and NTRK2
 ALK antibody  >3 publications with SHC3 and ALK
 APP antibody  >2 publications with SHC3 and APP
 Products by Pathway  Pathway Diagram
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 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
Diseases associated with anti-SHC3 antibodyOrgans/Tissues associated with anti-SHC3 antibody
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >4 publications with SHC3 and Brain Diseases
 Prenatal Injuries Antibodies  >1 publications with SHC3 and Prenatal Injuries
 Carcinoma Antibodies  >1 publications with SHC3 and Carcinoma
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with SHC3 and Prenatal Exposure Delayed Effects
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >17 publications with SHC3 and Brain
 Blood Antibodies  >2 publications with SHC3 and Blood
 Muscle Antibodies  >2 publications with SHC3 and Muscle
 Eye Antibodies  >2 publications with SHC3 and Eye
 Heart Antibodies  >1 publications with SHC3 and Heart
 Embryonic Tissue Antibodies  >1 publications with SHC3 and Embryonic Tissue
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