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anti-SHC4 antibody :: Rabbit anti-Human SHC4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1493430
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SHC4, Polyclonal Antibody

★Popular Item★
 Also Known As   

SHC4 Antibody

 Product Synonym Names    Rai-like protein; RaLP; SHC-transforming protein D; hShcD; Src homology 2 domain-containing-transforming protein C4; SH2 domain protein C4
 Product Gene Name   

anti-SHC4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q6S5L8
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
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 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human SHC-transforming protein 4 protein (1-185aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-165482
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-SHC4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SHC4 antibody

   Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
 Applications Tested/Suitable for anti-SHC4 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-SHC4 antibody    Recommended dilution: WB:1:500-2000
IHC:1:20-1:200
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 Western Blot (WB) of anti-SHC4 antibody    Western blot
All lanes: SHC4 antibody at 6ug/ml+jurkat whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 69,43 kDa
Observed band size: 69 kDa

anti-SHC4 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-SHC4 antibody    Immunohistochemistry of paraffin-embedded human melanoma using MBS1493430 at dilution 1:100
anti-SHC4 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for SHC4. It may not necessarily be applicable to this product.
 NCBI GI #    222446609
 NCBI GeneID    399694
 NCBI Accession #    NP_976224.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_203349.3 [Other Products]
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 UniProt Primary Accession #    Q6S5L8 [Other Products]
 UniProt Secondary Accession #    Q6UXQ3; Q8IYW3 [Other Products]
 UniProt Related Accession #    Q6S5L8 [Other Products]
 Molecular Weight    42,782 Da
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 NCBI Official Full Name    SHC-transforming protein 4
 NCBI Official Synonym Full Names    SHC (Src homology 2 domain containing) family member 4
 NCBI Official Symbol    SHC4 [Similar Products]
 NCBI Official Synonym Symbols   
RaLP; SHCD
[Similar Products]
 NCBI Protein Information    SHC-transforming protein 4
 UniProt Protein Name    SHC-transforming protein 4
 UniProt Synonym Protein Names   
Rai-like protein; RaLP; SHC-transforming protein D; hShcD; Src homology 2 domain-containing-transforming protein C4; SH2 domain protein C4
 Protein Family    SHC-transforming protein
 UniProt Gene Name    SHC4 [Similar Products]
 UniProt Synonym Gene Names    SHCD; RaLP; hShcD; SH2 domain protein C4 [Similar Products]
 UniProt Entry Name    SHC4_HUMAN
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 UniProt Comments for SHC4    SHC4: Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 15q21.1-q21.2

Cellular Component: cell junction; intracellular; plasma membrane; postsynaptic membrane

Molecular Function: protein binding; protein domain specific binding; receptor tyrosine kinase binding

Biological Process: apoptosis; positive regulation of cell proliferation; regulation of gene expression; stem cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway
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 Research Articles on SHC4    1. The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SHC4 antibodyPathways associated with anti-SHC4 antibody
 Reference Product  PubMed Publications
 GRB2 antibody  >2 publications with SHC4 and GRB2
 EGFR antibody  >2 publications with SHC4 and EGFR
 IGF1R antibody  >1 publications with SHC4 and IGF1R
 Products by Pathway  Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
Diseases associated with anti-SHC4 antibodyOrgans/Tissues associated with anti-SHC4 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1 publications with SHC4 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >1 publications with SHC4 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with SHC4 and Brain
 Skin Antibodies  >2 publications with SHC4 and Skin
 Connective Tissue Antibodies  >1 publications with SHC4 and Connective Tissue
 Embryonic Tissue Antibodies  >1 publications with SHC4 and Embryonic Tissue
 Uncharacterized Tissue Antibodies  >1 publications with SHC4 and Uncharacterized Tissue
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