P34896.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Serine hydroxymethyltransferase, cytosolic
NCBI Official Synonym Full Names
serine hydroxymethyltransferase 1
NCBI Official Synonym Symbols
NCBI Protein Information
serine hydroxymethyltransferase, cytosolic
UniProt Protein Name
Serine hydroxymethyltransferase, cytosolic
UniProt Synonym Protein Names
Glycine hydroxymethyltransferase; Serine methylase
UniProt Synonym Gene Names
NCBI Summary for SHMT1
This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
UniProt Comments for SHMT1
SHMT1: Interconversion of serine and glycine. Belongs to the SHMT family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Amino Acid Metabolism - glycine, serine and threonine; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 2.1.2.1; Energy Metabolism - methane; Lyase; Methyltransferase; Mitochondrial; Other Amino Acids Metabolism - cyanoamino acid
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component: cytosol; nucleus
Molecular Function: glycine hydroxymethyltransferase activity; identical protein binding; mRNA 5'-UTR binding; protein binding; protein homodimerization activity; pyridoxal phosphate binding; translation repressor activity, nucleic acid binding
Biological Process: carnitine biosynthetic process; folic acid metabolic process; glycine metabolic process; L-serine catabolic process; L-serine metabolic process; negative regulation of translation; protein homotetramerization; protein tetramerization; purine base biosynthetic process; tetrahydrofolate metabolic process
Research Articles on SHMT1
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Products associated with anti-SHMT1 antibody
Pathways associated with anti-SHMT1 antibody
Diseases associated with anti-SHMT1 antibody
Organs/Tissues associated with anti-SHMT1 antibody
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