Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow SHP-1 rightarrow Polyclonal SHP-1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Aromatase (ARO) Recombinant Protein
 • Albumin Antibody
 • GP ELISA Kit
 • Axis Inhibition Protein (AXIN) ELISA Kit
 • Keratan Sulfate (KS) ELISA Kit
 • aldosterone, ALD ELISA Kit
 • CRF-RI Antibody
 • (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB Recombinant Protein
 • A Disintegrin and Metalloprotease 21 (ADAM21) ELISA Kit
 • KCNH1 Antibody
 • Claudin 3 (CLDN3) ELISA Kit
 • RASA1 Antibody
 • Desmoglein 1 (DSG1) ELISA Kit
 • MAD1 (Phospho-Ser428) Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-SHP-1 antibody :: Rabbit SHP-1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9406467
Unit / Price
0.05 mL  /  $200 +1 FREE 8GB USB
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SHP-1, Polyclonal Antibody

★Popular Item★
 Also Known As   

SHP-1 (Phospho-Tyr536) Antibody

 Product Synonym Names    70Z-SHP; HCP; HCPH; Hematopoietic cell protein-tyrosine phosphatase; PTN6
 Product Gene Name   

anti-SHP-1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    176883
 3D Structure    ModBase 3D Structure for P29350
Section Bar
 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Specificity    The antibody detects endogenous level of SHP-1 only when phosphorylated at tyrosine 536.
 Purity/Purification    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
 Form/Format    Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1.0 mg/ml (lot specific)
Section Bar
 Immunogen Type    Peptide-KLH
 Immunogen Description    Peptide sequence around phosphorylation site of tyrosine 536 (S-E-Y(p)-G-N) derived from Human SHP-1.
 Modification    Phospho-Tyr536
 Target Name    SHP-1
Section Bar
 Preparation and Storage    Store at -20 degree C for long term preservation (recommended). Store at 4 degree C for short term use.
 Other Notes    Small volumes of anti-SHP-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-SHP-1 antibody

   Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.
 Product Categories/Family for anti-SHP-1 antibody    Phospho-specific Ab
 Applications Tested/Suitable for anti-SHP-1 antibody   

Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-SHP-1 antibody    Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:200
Section Bar
 Immunohistochemistry (IHC) of anti-SHP-1 antibody    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using SHP-1(Phospho-Tyr536) Antibody (left) or the same antibody preincubated with blocking peptide(right).
anti-SHP-1 antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunofluorescence (IF) of anti-SHP-1 antibody    Immunofluorescence staining of methanol-fixed Hela cells using SHP-1(Phospho-Tyr536) Antibody.
anti-SHP-1 antibody Immunofluorescence (IF) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for SHP-1. It may not necessarily be applicable to this product.
 NCBI GI #    18104989
 NCBI GeneID    5777
 NCBI Accession #    NP_002822.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002831.5 [Other Products]
Section Bar
 UniProt Primary Accession #    P29350 [Other Products]
 UniProt Secondary Accession #    Q969V8; Q9UK67; A8K306; G3V0F8 [Other Products]
 UniProt Related Accession #    P29350 [Other Products]
 Molecular Weight    70,131 Da
Table BarTOPTable Bar
 NCBI Official Full Name    tyrosine-protein phosphatase non-receptor type 6 isoform 1
 NCBI Official Synonym Full Names    protein tyrosine phosphatase, non-receptor type 6
 NCBI Official Symbol    PTPN6 [Similar Products]
 NCBI Official Synonym Symbols   
HCP; HCPH; SHP1; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1
[Similar Products]
 NCBI Protein Information    tyrosine-protein phosphatase non-receptor type 6
 UniProt Protein Name    Tyrosine-protein phosphatase non-receptor type 6
 UniProt Synonym Protein Names   
Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C; PTP-1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1
 UniProt Gene Name    PTPN6 [Similar Products]
 UniProt Synonym Gene Names    HCP; PTP1C; PTP-1C [Similar Products]
 UniProt Entry Name    PTN6_HUMAN
Section Bar
 NCBI Summary for SHP-1    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for SHP-1    Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
Table BarTOPTable Bar
 Research Articles on SHP-1    1. SHP-1 expression ws lower in PBMCs from unmedicated schizophrenics. The promoter region was hypermethylated. Silencing SHP-1 induced IKK/NF-kB and pro-inflammatory cytokines. SHP-1 expression may explain 30% of the clinical negative symptom variance.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-SHP-1 antibodyPathways associated with anti-SHP-1 antibody
 Reference Product  PubMed Publications
 SRC antibody  >546 publications with SHP-1 and SRC
 GAB1 antibody  >20 publications with SHP-1 and GAB1
 EGFR antibody  >15 publications with SHP-1 and EGFR
 SIRPA antibody  >7 publications with SHP-1 and SIRPA
 BLNK antibody  >4 publications with SHP-1 and BLNK
 SSTR2 antibody  >4 publications with SHP-1 and SSTR2
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
Diseases associated with anti-SHP-1 antibodyOrgans/Tissues associated with anti-SHP-1 antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >130 publications with SHP-1 and Immune System Diseases
 Inflammation Antibodies  >77 publications with SHP-1 and Inflammation
 Death Antibodies  >65 publications with SHP-1 and Death
 Necrosis Antibodies  >42 publications with SHP-1 and Necrosis
 Nervous System Diseases Antibodies  >28 publications with SHP-1 and Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >28 publications with SHP-1 and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >24 publications with SHP-1 and Liver Diseases
 Lung Diseases Antibodies  >23 publications with SHP-1 and Lung Diseases
 Liver Neoplasms Antibodies  >23 publications with SHP-1 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >22 publications with SHP-1 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >445 publications with SHP-1 and Blood
 Bone Antibodies  >89 publications with SHP-1 and Bone
 Bone Marrow Antibodies  >82 publications with SHP-1 and Bone Marrow
 Liver Antibodies  >60 publications with SHP-1 and Liver
 Brain Antibodies  >49 publications with SHP-1 and Brain
 Muscle Antibodies  >44 publications with SHP-1 and Muscle
 Spleen Antibodies  >37 publications with SHP-1 and Spleen
 Lung Antibodies  >36 publications with SHP-1 and Lung
 Kidney Antibodies  >35 publications with SHP-1 and Kidney
 Skin Antibodies  >27 publications with SHP-1 and Skin
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions