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anti-SIGLEC11 antibody :: Rabbit anti-Human SIGLEC11 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS626763
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SIGLEC11, Polyclonal Antibody

★Popular Item★
 Also Known As   

SIGLEC11, CT (Sialic Acid-binding Ig-like Lectin 11, Sialic Acid-binding Lectin 11, Siglec-11, UNQ9222/PRO28718)

 Product Synonym Names    Anti -SIGLEC11, CT (Sialic Acid-binding Ig-like Lectin 11, Sialic Acid-binding Lectin 11, Siglec-11, UNQ9222/PRO28718)
 Product Gene Name   

anti-SIGLEC11 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (50452250..50464429, complement). Location: 19q13.33
 OMIM    607157
 3D Structure    ModBase 3D Structure for Q96RL6
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes human SIGLEC11.
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.09% sodium azide.
 Concentration    0.32mg/ml (lot specific)
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 Immunogen    KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 631-662 in the C-terminal region of human Siglec 11, UniProt Accession #AAK72907; Q96RL6
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-SIGLEC11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-SIGLEC11 antibody

   SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have one or more cytoplasmic immune receptor tyrosine-based inhibitory motifs (ITIM). SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6. Sequence analysis predicted that the 697aa SIGLEC10 protein contains a signal peptide, an N-terminal V-set Ig-like domain and four C2-set Ig-like domains, five potential N-linked glycosylation sites, a transmembrane region, and a 126-residue cytoplasmic tail with 3 putative ITIMs. Northern blot analysis detected a major 3.0-kb SIGLEC10 transcript, with highest levels in spleen, lymph node, blood leukocytes, and appendix. Little or no expression was observed in pancreas, thyroid, and testis. Flow cytometric analysis demonstrated eosinophil-specific expression of SIGLEC10, but at a lower level than that of SIGLEC8. Expression was also detected on monocytes and a CD16-positive/CD56-negative natural killer-like lymphocyte population. After sialidase treatment, which is necessary for unmasking the sialic acid-binding site on SIGLECs interacting with cell surface sialic acids, cells expressing SIGLEC10 bound to red blood cells. Immunoprecipitation analysis indicated expression of a 100- to 120-kD monomeric protein, higher than the predicted molecular mass, suggesting that SIGLEC10 is glycosylated.
 Product Categories/Family for anti-SIGLEC11 antibody    Antibodies; Abs to Lectins
 Applications Tested/Suitable for anti-SIGLEC11 antibody   

Western Blot, ELISA (EL/EIA), Immunohistochemistry (IHC)
Other applications not tested.

 Application Notes for anti-SIGLEC11 antibody    Suitable for use in ELISA and Immunohistochemistry.
Dilution:
Western Blot: 1:1,000
Immunohistochemistry (FFPE): 1:10-1:50
Optimal dilutions to be determined by the researcher.
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 Western Blot of anti-SIGLEC11 antibody    Western Blot analysis in MCF-7 cell line Iysates (3Sug/lane) using MBS626763. This demonstrates that MBS626763 detected the SIGLEC 11 protein (arrow).
anti-SIGLEC11 antibody Western Blot (WB) image
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  Immunohistochemistry of anti-SIGLEC11 antibody    Immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue using MBS626763 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS626763 for immunohistochemistry.
anti-SIGLEC11 antibody  Immunohistochemistry (IHC) image
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NCBI/Uniprot data below describe general gene information for SIGLEC11. It may not necessarily be applicable to this product.
 NCBI GI #    205830470
 NCBI GeneID    114132
 NCBI Accession #    NP_443116.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_052884.2 [Other Products]
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 UniProt Primary Accession #    Q96RL6 [Other Products]
 UniProt Related Accession #    Q96RL6 [Other Products]
 Molecular Weight    75,795 Da [Similar Products]
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 NCBI Official Full Name    sialic acid-binding Ig-like lectin 11 isoform 1
 NCBI Official Synonym Full Names    sialic acid binding Ig-like lectin 11
 NCBI Official Symbol    SIGLEC11 [Similar Products]
 NCBI Protein Information    sialic acid-binding Ig-like lectin 11; siglec-11; OTTHUMP00000211434; OTTHUMP00000211435; sialic acid-binding lectin 11
 UniProt Protein Name    Sialic acid-binding Ig-like lectin 11
 Protein Family    Sialic acid-binding Ig-like lectin
 UniProt Gene Name    SIGLEC11 [Similar Products]
 UniProt Entry Name    SIG11_HUMAN
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 NCBI Summary for SIGLEC11    SIGLECs are a family of cell surface lectins defined by shared structural motifs in the first 2 immunoglobulin (Ig)-like domains and by their ability to recognize sialic acids via the first Ig V set domain.[supplied by OMIM]
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 UniProt Comments for SIGLEC11    SIGLEC11: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8- linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: integral to membrane

Molecular Function: carbohydrate binding

Biological Process: cell adhesion
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 Research Articles on SIGLEC11    1. Siglec-11 ectopically expressed on murine microglia interacts with PSA on neurons, reduces LPS-induced gene transcription of proinflammatory mediators, impairs phagocytosis and alleviates microglial neurotoxicity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SIGLEC11 antibodyOrgans/Tissues associated with anti-SIGLEC11 antibody
 Reference Product  PubMed Publications
 PTPN6 antibody  >1 publications with SIGLEC11 and PTPN6
 PTPN11 antibody  >1 publications with SIGLEC11 and PTPN11
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with SIGLEC11 and Brain
 Lung Antibodies  >1 publications with SIGLEC11 and Lung
 Ovary Antibodies  >1 publications with SIGLEC11 and Ovary
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