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anti-SIK2 antibody :: Rabbit SIK2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150970
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SIK2, Polyclonal Antibody

 Also Known As   

SIK2 Antibody

 Product Synonym Names    SIK2; QIK; SNF1LK2; LOH11CR1I; KIAA0781; QIK; Qin-induced kinase; SIK-2; salt-inducible kinase 2
 Product Gene Name   

anti-SIK2 antibody

[Similar Products]
 Antibody/Peptide Pairs    SIK2 peptide (MBS153082) is used for blocking the activity of SIK2 antibody (MBS150970)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608973
 3D Structure    ModBase 3D Structure for Q9H0K1
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    SIK2 antibody is predicted to not cross-react with other SIK protein family members.
 Purity/Purification    SIK2 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    SIK2 antibody was raised against a 16 amino acid synthetic peptide near the center of human SIK2.
 Buffer    SIK2 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    SIK2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-SIK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SIK2 antibody

   SIK2 Antibody: Salt-inducible kinase 2 (SIK2), like its closely related homolog SIK1, belongs AMPK subfamily of the Ser/Thr protein kinase family and negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1 alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation.
 Applications Tested/Suitable for anti-SIK2 antibody   

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

 Application Notes for anti-SIK2 antibody    SIK2 antibody can be used for detection of SIK2 by Western blot at 1 mug/mL.
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 Western Blot (WB) of anti-SIK2 antibody    Western blot analysis of SIK2 in SW480 cell lysate with SIK2 antibody at 1 μg/mL.
anti-SIK2 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-SIK2 antibody    Immunofluorescence of SIK2 in SW480 cells with SIK2 antibody at 5 μg/ml.
anti-SIK2 antibody Immunofluorescence (IF) image
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 Immunocytochemistry (ICC) of anti-SIK2 antibody    Immunocytochemistry of SIK2 in SW480 cells with SIK2 antibody at 2.5 μg/ml.
anti-SIK2 antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for SIK2. It may not necessarily be applicable to this product.
 NCBI GI #    38569460
 NCBI GeneID    23235
 NCBI Accession #    EAW67148 [Other Products]
 NCBI GenBank Nucleotide #    NM_015191.2 [Other Products]
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 UniProt Primary Accession #    Q9H0K1 [Other Products]
 UniProt Secondary Accession #    O94878; Q17RV0; Q6AZE2; Q76N03; Q8NCV7; Q96CZ8; A8K5B8; B0YJ94 [Other Products]
 UniProt Related Accession #    Q9H0K1 [Other Products]
 Molecular Weight    103,915 Da
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 NCBI Official Full Name    serine/threonine-protein kinase SIK2
 NCBI Official Synonym Full Names    salt-inducible kinase 2
 NCBI Official Symbol    SIK2 [Similar Products]
 NCBI Official Synonym Symbols   
QIK; SIK-2; SNF1LK2; LOH11CR1I
[Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase SIK2; SNF1-like kinase 2; qin-induced kinase; salt-inducible protein kinase 2; salt-inducible serine/threonine kinase 2; serine/threonine-protein kinase SNF1-like kinase 2
 UniProt Protein Name    Serine/threonine-protein kinase SIK2
 UniProt Synonym Protein Names   
Qin-induced kinase; Salt-inducible kinase 2; SIK-2; Serine/threonine-protein kinase SNF1-like kinase 2
 Protein Family    Serine/threonine-protein kinase
 UniProt Gene Name    SIK2 [Similar Products]
 UniProt Synonym Gene Names    ; SIK-2 [Similar Products]
 UniProt Entry Name    SIK2_HUMAN
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 UniProt Comments for SIK2    QIK: a serine/threonine kinase of the CAMKL family and related to AMPK. Specifically expressed in adipose tissues. Like AMPK, QIK is phosphorylated and activated by LKB1. Part of a molecular complex including TORC2 and calcineurin that regulates the effects of circulating glucose and gut hormones during feeding on TORC2-mediated gene expression. In mice, insulin promotes the phosphorylation and ubiquitin-dependent degradation of TORC2, inhibiting gluconeogenic gene expression during re-feeding. In response to insulin, Akt2 phosphorylates and activates QIK which in turn stimulates the phosphorylation and cytoplasmic translocation of TORC2 where it associates with COP1, which promotes its ubiquitination and proteasomal degradation. Phosphorylates Ser794 of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3.

Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, CAMK; CAMK group; CAMKL family; QIK subfamily

Chromosomal Location of Human Ortholog: 11q23.1

Cellular Component: cytoplasm; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; magnesium ion binding; ATP binding

Biological Process: regulation of insulin receptor signaling pathway; protein amino acid autophosphorylation; insulin receptor signaling pathway; protein amino acid phosphorylation
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 Research Articles on SIK2    1. a mechanism by which the interplay between SIK2 and p97/VCP contributes to the regulation of ERAD in mammalian cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SIK2 antibodyPathways associated with anti-SIK2 antibody
 Reference Product  PubMed Publications
 CRTC2 antibody  >10 publications with SIK2 and CRTC2
 IRS1 antibody  >4 publications with SIK2 and IRS1
 CRTC3 antibody  >3 publications with SIK2 and CRTC3
 STK11 antibody  >3 publications with SIK2 and STK11
 Products by Pathway  Pathway Diagram
 LKB1 Signaling Events Pathway antibodies  LKB1 Signaling Events Pathway Diagram
Diseases associated with anti-SIK2 antibodyOrgans/Tissues associated with anti-SIK2 antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >4 publications with SIK2 and Disease Models, Animal
 Hyperglycemia Antibodies  >4 publications with SIK2 and Hyperglycemia
 Inflammation Antibodies  >4 publications with SIK2 and Inflammation
 Immune System Diseases Antibodies  >2 publications with SIK2 and Immune System Diseases
 Liver Diseases Antibodies  >2 publications with SIK2 and Liver Diseases
 Fatty Liver Antibodies  >2 publications with SIK2 and Fatty Liver
 Hypertrophy Antibodies  >1 publications with SIK2 and Hypertrophy
 Necrosis Antibodies  >1 publications with SIK2 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >6 publications with SIK2 and Liver
 Adipose Tissue Antibodies  >5 publications with SIK2 and Adipose Tissue
 Brain Antibodies  >5 publications with SIK2 and Brain
 Blood Antibodies  >4 publications with SIK2 and Blood
 Pancreas Antibodies  >3 publications with SIK2 and Pancreas
 Connective Tissue Antibodies  >3 publications with SIK2 and Connective Tissue
 Prostate Antibodies  >1 publications with SIK2 and Prostate
 Heart Antibodies  >1 publications with SIK2 and Heart
 Eye Antibodies  >1 publications with SIK2 and Eye
 Kidney Antibodies  >1 publications with SIK2 and Kidney
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