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anti-SIN3A antibody :: Rabbit SIN3A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS127794
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SIN3A, Polyclonal Antibody

 Also Known As   

SIN3A Polyclonal Antibody

 Product Synonym Names    DKFZp434K2235; FLJ90319; KIAA0700
 Product Gene Name   

anti-SIN3A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607776
 3D Structure    ModBase 3D Structure for Q96ST3
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human SIN3A
 Calculated Molecular Weight    145kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-SIN3A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-SIN3A antibody

   SIN3 was originally identified as a negative regulator of transcription in budding yeast (1,2). Since then, three isoforms of the SIN3 proteins have been identified in mammalian cells, as products of two different genes, SIN3A and SIN3B (3,4). Both SIN3A and SIN3B are nuclear proteins that function as scaffolding subunits for the multi-subunit SIN3 transcriptional repressor complex, containing SIN3A or SIN3B, HDAC1, HDAC2, SDS3, RBBP4/RBAP48, RBBP7/RBAP46, SAP30, and SAP18 (3,4). SIN3 proteins contain four paired amphipathic alpha-helix (PAH) motifs that function in the recruitment of the SIN3 complex to target genes by binding a multitude of DNA-binding transcriptional repressor proteins, including Mad1, p53, E2F4, HCF-1, AML1, Elk-1, NRSF, CTCF, ERalpha, and MeCP2 (3,4). In addition, SIN3 proteins contain an HDAC interaction domain (HID), which mediates binding of HDAC1 and HDAC2 via the SDS3 bridging protein, and a highly conserved region (HCR) at the carboxy terminus, which contributes to repressor protein binding (3,4). RBBP4 and RBBP7 proteins also bind to SDS3 and contribute to nucleosome binding of the complex. The SIN3 complex functions to repress transcription, in part, by deacetylating histones at target gene promoters (3,4). In addition, recent studies have shown that SIN3 is recruited to the coding regions of repressed and active genes, where it deacetylates histones and suppresses spurious transcription by RNA polymerase II (3,5). In addition to histone deacetylase activity, the SIN3 complex associates with histone methyltransferase (ESET), histone demethylase (JARID1A/RBP2), ATP-dependent chromatin remodeling (SWI/SNF), methylcytosine dioxygenase (TET1), and O-GlcNAc transferase (OGT) activities, all of which appear to contribute to the regulation of target genes (5-9). The SIN3 complex is critical for proper regulation of embryonic development, cell growth and proliferation, apoptosis, DNA replication, DNA repair, and DNA methylation (imprinting and X-chromosome inactivation) (3,4).
 Product Categories/Family for anti-SIN3A antibody    Polyclonal
 Applications Tested/Suitable for anti-SIN3A antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), CHIP

 Application Notes for anti-SIN3A antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:50 - 1:200
IP: 1:50 - 1:200
ChIP: 1:20 - 1:100
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 Western Blot (WB) of anti-SIN3A antibody    Western blot analysis of extracts of various cell lines, using SIN3A antibody.
anti-SIN3A antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-SIN3A antibody    Immunofluorescence analysis of U2OS cell using SIN3A antibody. Blue: DAPI for nuclear staining.
anti-SIN3A antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for SIN3A. It may not necessarily be applicable to this product.
 NCBI GI #    37999759
 NCBI GeneID    25942
 NCBI Accession #    Q96ST3.2 [Other Products]
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 UniProt Primary Accession #    Q96ST3 [Other Products]
 UniProt Secondary Accession #    Q8N8N4; Q8NC83; Q8WV18; Q96L98; Q9UFQ1; B2RNS5 [Other Products]
 UniProt Related Accession #    Q96ST3 [Other Products]
 Molecular Weight    1273
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 NCBI Official Full Name    Paired amphipathic helix protein Sin3a
 NCBI Official Synonym Full Names    SIN3 transcription regulator family member A
 NCBI Official Symbol    SIN3A [Similar Products]
 NCBI Protein Information    paired amphipathic helix protein Sin3a; SIN3A; transcriptional regulator, SIN3A; transcriptional corepressor Sin3a; transcriptional co-repressor Sin3A; SIN3 transcription regulator homolog A; SIN3 homolog A, transcription regulator; histone deacetylase complex subunit Sin3a
 UniProt Protein Name    Paired amphipathic helix protein Sin3a
 UniProt Synonym Protein Names   
Histone deacetylase complex subunit Sin3a; Transcriptional corepressor Sin3a
 Protein Family    Paired amphipathic helix protein
 UniProt Gene Name    SIN3A [Similar Products]
 UniProt Entry Name    SIN3A_HUMAN
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 NCBI Summary for SIN3A    The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SIN3A    SIN3A: Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Interacts with BAZ2A, MXD3, MXD4, MBD2, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1 and SMYD2. Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30. Interacts with ARID4B, BRMS1L, DACH1, HCFC1, HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ, SUDS3 and TOPORS. Interacts with TET1; the interaction recruits SIN3A to gene promoters. Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression in parallel with histone deacetylase.

Protein type: Nucleolus; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 15q24.2

Cellular Component: kinetochore; nucleoplasm; transcription factor complex; intercellular bridge; Sin3 complex; transcriptional repressor complex; cytoplasm; nucleolus; nucleus

Molecular Function: protein binding; protein deacetylase activity; protein complex binding; chromatin binding; histone deacetylase activity; transcription factor activity

Biological Process: positive regulation of chromatin silencing; transcription, DNA-dependent; in utero embryonic development; rhythmic process; histone deacetylation; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; response to organic nitrogen; regulation of gene expression, epigenetic; protein amino acid deacetylation; negative regulation of gene expression, epigenetic; response to methylglyoxal; negative regulation of circadian rhythm; positive regulation of transcription from RNA polymerase II promoter; gene expression; hemopoietic progenitor cell differentiation; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; positive regulation of defense response to virus by host; negative regulation of transcription, DNA-dependent; blood coagulation; DNA replication; activation of innate immune response; negative regulation of apoptosis; aging
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 Research Articles on SIN3A    1. EBNA3C binds strongly to BATF/IRF4/SPI1/RUNX3 sites to enhance transcription and recruits RBPJ/Sin3A- and REST/NRSF-repressive complexes to repress p14(ARF) and p16(INK4A) expression
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SIN3A antibodyPathways associated with anti-SIN3A antibody
 Reference Product  PubMed Publications
 HDAC1 antibody  >84 publications with SIN3A and HDAC1
 HDAC2 antibody  >31 publications with SIN3A and HDAC2
 MECP2 antibody  >27 publications with SIN3A and MECP2
 SAP30 antibody  >8 publications with SIN3A and SAP30
 SKI antibody  >4 publications with SIN3A and SKI
 MXD1 antibody  >3 publications with SIN3A and MXD1
 RBBP4 antibody  >3 publications with SIN3A and RBBP4
 RBBP7 antibody  >2 publications with SIN3A and RBBP7
 TP53 antibody  >1 publications with SIN3A and TP53
 Products by Pathway  Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Epigenetic Regulation Of Gene Expression Pathway antibodies  Epigenetic Regulation Of Gene Expression Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Signaling Events Mediated By Gli Proteins Pathway antibodies  Hedgehog Signaling Events Mediated By Gli Proteins Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with anti-SIN3A antibodyOrgans/Tissues associated with anti-SIN3A antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >13 publications with SIN3A and Nervous System Diseases
 Skin Diseases Antibodies  >11 publications with SIN3A and Skin Diseases
 Breast Neoplasms Antibodies  >8 publications with SIN3A and Breast Neoplasms
 Brain Diseases Antibodies  >7 publications with SIN3A and Brain Diseases
 Neoplasms, Experimental Antibodies  >7 publications with SIN3A and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >7 publications with SIN3A and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >5 publications with SIN3A and Neoplasm Metastasis
 Necrosis Antibodies  >4 publications with SIN3A and Necrosis
 Inflammation Antibodies  >4 publications with SIN3A and Inflammation
 Liver Diseases Antibodies  >4 publications with SIN3A and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >23 publications with SIN3A and Brain
 Blood Antibodies  >15 publications with SIN3A and Blood
 Thyroid Antibodies  >13 publications with SIN3A and Thyroid
 Muscle Antibodies  >12 publications with SIN3A and Muscle
 Embryonic Tissue Antibodies  >9 publications with SIN3A and Embryonic Tissue
 Lung Antibodies  >9 publications with SIN3A and Lung
 Liver Antibodies  >8 publications with SIN3A and Liver
 Vascular Antibodies  >7 publications with SIN3A and Vascular
 Eye Antibodies  >7 publications with SIN3A and Eye
 Testis Antibodies  >7 publications with SIN3A and Testis
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