Related Product Information for
anti-SIN3A antibody
SIN3 was originally identified as a negative regulator of transcription in budding yeast (1, 2). Since then, three isoforms of the SIN3 proteins have been identified in mammalian cells, as products of two different genes, SIN3A and SIN3B (3, 4). Both SIN3A and SIN3B are nuclear proteins that function as scaffolding subunits for the multi-subunit SIN3 transcriptional repressor complex, containing SIN3A or SIN3B, HDAC1, HDAC2, SDS3, RBBP4/RBAP48, RBBP7/RBAP46, SAP30, and SAP18 (3, 4). SIN3 proteins contain four paired amphipathic alpha-helix (PAH) motifs that function in the recruitment of the SIN3 complex to target genes by binding a multitude of DNA-binding transcriptional repressor proteins, including Mad1, p53, E2F4, HCF-1, AML1, Elk-1, NRSF, CTCF, ERalpha, and MeCP2 (3, 4). In addition, SIN3 proteins contain an HDAC interaction domain (HID), which mediates binding of HDAC1 and HDAC2 via the SDS3 bridging protein, and a highly conserved region (HCR) at the carboxy terminus, which contributes to repressor protein binding (3, 4). RBBP4 and RBBP7 proteins also bind to SDS3 and contribute to nucleosome binding of the complex. The SIN3 complex functions to repress transcription, in part, by deacetylating histones at target gene promoters (3, 4). In addition, recent studies have shown that SIN3 is recruited to the coding regions of repressed and active genes, where it deacetylates histones and suppresses spurious transcription by RNA polymerase II (3, 5). In addition to histone deacetylase activity, the SIN3 complex associates with histone methyltransferase (ESET), histone demethylase (JARID1A/RBP2), ATP-dependent chromatin remodeling (SWI/SNF), methylcytosine dioxygenase (TET1), and O-GlcNAc transferase (OGT) activities, all of which appear to contribute to the regulation of target genes (5-9). The SIN3 complex is critical for proper regulation of embryonic development, cell growth and proliferation, apoptosis, DNA replication, DNA repair, and DNA methylation (imprinting and X-chromosome inactivation) (3, 4).
NCBI Accession #
AAA69773.2
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
145,474 Da
NCBI Official Full Name
Sin3A, partial
NCBI Official Synonym Full Names
transcriptional regulator, SIN3A (yeast)
NCBI Official Synonym Symbols
Sin3; mSin3A; AW553200; mKIAA4126 [Similar Products]
NCBI Protein Information
paired amphipathic helix protein Sin3a; histone deacetylase complex subunit Sin3a; transcriptional corepressor Sin3a; transcriptional regulator, SIN3 yeast homolog A
UniProt Protein Name
Paired amphipathic helix protein Sin3a
UniProt Synonym Protein Names
Histone deacetylase complex subunit Sin3a; Transcriptional corepressor Sin3a
UniProt Synonym Gene Names
UniProt Entry Name
SIN3A_MOUSE
UniProt Comments for SIN3A
SIN3A: Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Interacts with BAZ2A, MXD3, MXD4, MBD2, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1 and SMYD2. Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30. Interacts with ARID4B, BRMS1L, DACH1, HCFC1, HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ, SUDS3 and TOPORS. Interacts with TET1; the interaction recruits SIN3A to gene promoters. Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression in parallel with histone deacetylase.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Nucleolus
Cellular Component: nucleoplasm; kinetochore; transcription factor complex; intercellular bridge; protein complex; transcriptional repressor complex; Sin3 complex; cytoplasm; chromatin; nucleus
Molecular Function: protein binding; DNA binding; RNA binding; protein deacetylase activity; protein complex binding; chromatin binding; histone deacetylase activity; transcription factor binding; transcription factor activity; transcription corepressor activity
Biological Process: transcription from RNA polymerase II promoter; positive regulation of chromatin silencing; transcription, DNA-dependent; in utero embryonic development; rhythmic process; histone deacetylation; negative regulation of transcription from RNA polymerase II promoter; response to organic nitrogen; regulation of transcription, DNA-dependent; protein amino acid deacetylation; response to methylglyoxal; hemopoietic progenitor cell differentiation; negative regulation of circadian rhythm; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; positive regulation of defense response to virus by host; DNA replication; activation of innate immune response; aging; negative regulation of apoptosis
Research Articles on SIN3A
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Pathways associated with anti-SIN3A antibody
Diseases associated with anti-SIN3A antibody
Organs/Tissues associated with anti-SIN3A antibody
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