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anti-SIPA1L2 antibody :: Rabbit SIPA1L2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150183
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SIPA1L2, Polyclonal Antibody

 Also Known As   

SIPA1L2 Antibody

 Product Synonym Names    SIPA1L2; SPAL2; KIAA1389; Signal-induced proliferation-associated 1-like protein 2; SIPA1-like protein 2; signal-induced proliferation-associated 1 like 2
 Product Gene Name   

anti-SIPA1L2 antibody

[Similar Products]
 Antibody/Peptide Pairs    SIPA1L2 peptide (MBS152647) is used for blocking the activity of SIPA1L2 antibody (MBS150183)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    611609
 3D Structure    ModBase 3D Structure for Q9P2F8
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    SIPA1L2 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    SIPA1L2 antibody was raised against a 19 amino acid synthetic peptide from near the amino terminus of human SIPA1L2.
 Buffer    SIPA1L2 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    SIPA1L2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-SIPA1L2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SIPA1L2 antibody

   SIPA1L2 Antibody: Signal-induced proliferation associated-like protein 2 (SIPA1L2) is a member of the SIPA1 family of RapGAPs. Little is known of the role of the SIPA1L2 protein, but recent studies of SIPA indicate that its deregulation can cause myeloproliferative stem cell disorders in mice and increased metastases in human cancers. Other studies suggest SIPA1L1 may play important roles in embryo development and control of cell proliferation. Based on the amount of homology between SIPA family members, it is likely that SIPA1L2 plays a role in embryo development and cell proliferation, possibly including oncogenesis.
 Applications Tested/Suitable for anti-SIPA1L2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-SIPA1L2 antibody    SIPA1L2 antibody can be used for detection of SIPA1L2 by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-SIPA1L2 antibody    Western blot analysis of SIPA1L2 in rat brain tissue lysate with SIPA1L2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
anti-SIPA1L2 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-SIPA1L2 antibody    Immunofluorescence of SIPA1L2 in human brain tissue with SIPA1L2 antibody at 20 μg/mL.
anti-SIPA1L2 antibody Immunofluorescence (IF) image
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 Immunohistochemistry (IHC) of anti-SIPA1L2 antibody    Immunohistochemistry of SIPA1L2 in human brain tissue with SIPA1L2 antibody at 5 μg/mL.
anti-SIPA1L2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for SIPA1L2. It may not necessarily be applicable to this product.
 NCBI GI #    112421013
 NCBI GeneID    57568
 NCBI Accession #    NP_065859 [Other Products]
 NCBI GenBank Nucleotide #    NM_020808.3 [Other Products]
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 UniProt Primary Accession #    Q9P2F8 [Other Products]
 UniProt Secondary Accession #    Q2TV88; Q5VXR7; Q5VXR8; Q641Q4; Q8NA38; Q96DZ3; Q9H9F6 [Other Products]
 UniProt Related Accession #    Q9P2F8 [Other Products]
 Molecular Weight    84,536 Da
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 NCBI Official Full Name    signal-induced proliferation-associated 1-like protein 2
 NCBI Official Synonym Full Names    signal-induced proliferation-associated 1 like 2
 NCBI Official Symbol    SIPA1L2 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    signal-induced proliferation-associated 1-like protein 2; SPA-1-like 2; SIPA1-like protein 2
 UniProt Protein Name    Signal-induced proliferation-associated 1-like protein 2
 Protein Family    Signal-induced proliferation-associated 1-like protein
 UniProt Gene Name    SIPA1L2 [Similar Products]
 UniProt Synonym Gene Names    KIAA1389; SIPA1-like protein 2 [Similar Products]
 UniProt Entry Name    SI1L2_HUMAN
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 UniProt Comments for SIPA1L2    SIPA1L2: 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; GAPs, Ras

Chromosomal Location of Human Ortholog: 1q42.2

Molecular Function: GTPase activator activity

Biological Process: regulation of small GTPase mediated signal transduction; positive regulation of GTPase activity
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 Research Articles on SIPA1L2    1. Observational study of gene-disease association. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-SIPA1L2 antibody
 Products by Pathway  Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
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