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anti-SIRP-alpha1 antibody :: Rabbit SIRP-alpha1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2534603
Western Blot (WB)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SIRP-alpha1, Polyclonal Antibody

★Popular Item★
 Also Known As   

SIRP-alpha1 Polyclonal Antibody

 Product Synonym Names    SIRPA; BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP; Tyrosine-protein phosphatase non-receptor type substrate 1; SHP substrate 1; SHPS-1; Brain Ig-like molecule with tyrosine-based activation motifs; Bit; CD172 antigen-like family member A; Inhibito
 Product Gene Name   

anti-SIRP-alpha1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602461
 3D Structure    ModBase 3D Structure for P78324
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
 Concentration    1 mg/ml (lot specific)
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 Immunogen    Synthesized peptide derived from the C-terminal region of human SIRP-alpha1.
 Buffer    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-SIRP-alpha1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SIRP-alpha1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-SIRP-alpha1 antibody    WB: 1:500-1:2000, IHC: 1:50-1:200, ELISA: 1:5000-1:20000
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 Western Blot (WB) of anti-SIRP-alpha1 antibody    Western Blot analysis of various cells with SIRP-?1 Polyclonal Antibody.
anti-SIRP-alpha1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SIRP-alpha1. It may not necessarily be applicable to this product.
 NCBI GI #    2052056
 NCBI GeneID    140885
 NCBI Accession #    CAA71403.1 [Other Products]
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 UniProt Primary Accession #    P78324 [Other Products]
 UniProt Secondary Accession #    O00683; O43799; Q8N517; Q8TAL8; Q9H0Z2; Q9UDX2; Q9UIJ6; Q9Y4U9; A2A2E1; A8K411; B2R6C3 [Other Products]
 UniProt Related Accession #    P78324 [Other Products]
 Molecular Weight    Calculated MW: 55
Observed MW: 55
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 NCBI Official Full Name    SIRP-alpha1
 NCBI Official Synonym Full Names    signal regulatory protein alpha
 NCBI Official Symbol    SIRPA [Similar Products]
 NCBI Official Synonym Symbols   
BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1
[Similar Products]
 NCBI Protein Information    tyrosine-protein phosphatase non-receptor type substrate 1
 UniProt Protein Name    Tyrosine-protein phosphatase non-receptor type substrate 1
 UniProt Synonym Protein Names   
Brain Ig-like molecule with tyrosine-based activation motifs; Bit; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Macrophage fusion receptor; MyD-1 antigen; Signal-regulatory protein alpha-1; Sirp-alpha-1; Signal-regulatory protein alpha-2; Sirp-alpha-2; Signal-regulatory protein alpha-3; Sirp-alpha-3; p84; CD_antigen: CD172a
 UniProt Gene Name    SIRPA [Similar Products]
 UniProt Synonym Gene Names    BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP; SHP substrate 1; SHPS-1; Bit; Sirp-alpha-1; Sirp-alpha-2; Sirp-alpha-3 [Similar Products]
 UniProt Entry Name    SHPS1_HUMAN
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 NCBI Summary for SIRP-alpha1    The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SIRP-alpha1    SHPS1: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR. Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB. Binds PTK2B. Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis; Receptor, misc.

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: integral to membrane; membrane; plasma membrane

Molecular Function: SH3 domain binding

Biological Process: blood coagulation; cell adhesion; leukocyte migration
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 Research Articles on SIRP-alpha1    1. Loss of cell surface CD47 clustering formation and binding avidity to SIRPalpha facilitate apoptotic cell clearance by macrophages.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SIRP-alpha1 antibodyPathways associated with anti-SIRP-alpha1 antibody
 Reference Product  PubMed Publications
 CD47 antibody  >79 publications with SIRP-alpha1 and CD47
 PTPN11 antibody  >11 publications with SIRP-alpha1 and PTPN11
 PTPN6 antibody  >7 publications with SIRP-alpha1 and PTPN6
 GRB2 antibody  >5 publications with SIRP-alpha1 and GRB2
 Products by Pathway  Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 IL-1 Signaling Pathway antibodies  IL-1 Signaling Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
 Signal Regulatory Protein (SIRP) Family Interactions Pathway antibodies  Signal Regulatory Protein (SIRP) Family Interactions Pathway Diagram
Diseases associated with anti-SIRP-alpha1 antibodyOrgans/Tissues associated with anti-SIRP-alpha1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >27 publications with SIRP-alpha1 and Inflammation
 Diabetes Mellitus Antibodies  >16 publications with SIRP-alpha1 and Diabetes Mellitus
 Cardiovascular Diseases Antibodies  >16 publications with SIRP-alpha1 and Cardiovascular Diseases
 Death Antibodies  >12 publications with SIRP-alpha1 and Death
 Disease Models, Animal Antibodies  >12 publications with SIRP-alpha1 and Disease Models, Animal
 Breast Neoplasms Antibodies  >9 publications with SIRP-alpha1 and Breast Neoplasms
 Necrosis Antibodies  >8 publications with SIRP-alpha1 and Necrosis
 Lung Diseases Antibodies  >7 publications with SIRP-alpha1 and Lung Diseases
 Kidney Diseases Antibodies  >5 publications with SIRP-alpha1 and Kidney Diseases
 Liver Diseases Antibodies  >5 publications with SIRP-alpha1 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >90 publications with SIRP-alpha1 and Blood
 Vascular Antibodies  >25 publications with SIRP-alpha1 and Vascular
 Bone Antibodies  >20 publications with SIRP-alpha1 and Bone
 Muscle Antibodies  >20 publications with SIRP-alpha1 and Muscle
 Prostate Antibodies  >13 publications with SIRP-alpha1 and Prostate
 Heart Antibodies  >10 publications with SIRP-alpha1 and Heart
 Eye Antibodies  >10 publications with SIRP-alpha1 and Eye
 Lung Antibodies  >10 publications with SIRP-alpha1 and Lung
 Bone Marrow Antibodies  >9 publications with SIRP-alpha1 and Bone Marrow
 Skin Antibodies  >9 publications with SIRP-alpha1 and Skin
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