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anti-SLC6A20 antibody :: Rabbit anti-Human SIT1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS6004817 anti-SLC6A20 antibody
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SIT1 (SLC6A20), Polyclonal Antibody

 Also Known As   

SIT1, CT (SIT1, SIT, Signaling threshold-regulating transmembrane adapter 1, SHP2-interacting transmembrane adapter protein, Suppression-inducing transmembrane adapter 1, gp30/40)

 Product Synonym Names    Anti -SIT1, CT (SIT1, SIT, Signaling threshold-regulating transmembrane adapter 1, SHP2-interacting transmembrane adapter protein, Suppression-inducing transmembrane adapter 1, gp30/40)
 Product Gene Name   

anti-SLC6A20 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (45796941..45838039, complement). Location: 3p21.3
 OMIM    138500
 3D Structure    ModBase 3D Structure for Q9NP91
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Human
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
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 Immunogen    SIT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-189 amino acids from the C-terminal region of human SIT1.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-SLC6A20 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-SLC6A20 antibody

   Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells.
 Product Categories/Family for anti-SLC6A20 antibody    Antibodies; Abs to Transmembrane Proteins
 Applications Tested/Suitable for anti-SLC6A20 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-SLC6A20 antibody    Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
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NCBI/Uniprot data below describe general gene information for SLC6A20. It may not necessarily be applicable to this product.
 NCBI GI #    12408638
 NCBI GeneID    54716
 NCBI Accession #    NP_071800.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_022405.3 [Other Products]
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 UniProt Primary Accession #    Q9NP91 [Other Products]
 UniProt Secondary Accession #    O75590; Q8TF10; Q9NPQ2; Q9NQ77; A1A4F2 [Other Products]
 UniProt Related Accession #    Q9NP91 [Other Products]
 Molecular Weight    65,914 Da [Similar Products]
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 NCBI Official Full Name    sodium- and chloride-dependent transporter XTRP3 isoform 2
 NCBI Official Synonym Full Names    solute carrier family 6 (proline IMINO transporter), member 20
 NCBI Official Symbol    SLC6A20 [Similar Products]
 NCBI Official Synonym Symbols   
XT3; SIT1; Xtrp3
[Similar Products]
 NCBI Protein Information    sodium- and chloride-dependent transporter XTRP3; orphan transporter XT3; X transporter protein 3; transporter rB21A homolog; sodium/imino-acid transporter 1; neurotransmitter transporter RB21A; solute carrier family 6 (neurotransmitter transporter), member 20
 UniProt Protein Name    Sodium- and chloride-dependent transporter XTRP3
 UniProt Synonym Protein Names   
Sodium/imino-acid transporter 1; Solute carrier family 6 member 20; Transporter rB21A homolog
 Protein Family    Sodium- and chloride-dependent transporter
 UniProt Gene Name    SLC6A20 [Similar Products]
 UniProt Synonym Gene Names    SIT1; XT3; XTRP3 [Similar Products]
 UniProt Entry Name    S6A20_HUMAN
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 NCBI Summary for SLC6A20    Transport of small hydrophilic substances across cell membranes is mediated by substrate-specific transporter proteins which have been classified into several families of related genes. The protein encoded by this gene is a member of the subgroup of transporter with unidentified substrates within the Na+ and Cl- coupled transporter family. This gene is expressed in kidney, and its alternative splicing generates 2 transcript variants. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SLC6A20    SLC6A20: Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N- methylated amino acids. Involved in the transport of glycine. Defects in SLC6A20 are a cause of hyperglycinuria (HG). It is a condition characterized by excess of glycine in the urine. In some cases it is associated with renal colic and renal oxalate stones. Defects in SLC6A20 are a cause of iminoglycinuria (IG). It is a disorder of renal tubular reabsorption of glycine and imino acids (proline and hydroxyproline), marked by excessive levels of all three substances in the urine. Haploinsufficiency of SLC6A20 combined with deficiency of the neutral amino acid transporter SLC6A19 or partially inactivating mutations in SLC36A2, is responsible for iminoglycinuria. Additional polymorphisms and mutations in SLC6A18 can contribute to the IG phenotype in some families. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A20 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: integral to plasma membrane; apical plasma membrane; plasma membrane

Molecular Function: neurotransmitter:sodium symporter activity; amino acid transmembrane transporter activity

Biological Process: glycine transport; neurotransmitter transport; amino acid transport; ion transport; proline transport; transmembrane transport

Disease: Iminoglycinuria; Hyperglycinuria
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 Research Articles on SLC6A20    1. Using homology modeling we identified two highly conserved Na(+)-binding sites and a putative Cl(-)-binding site of SLC6A20.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to SIT1, CT (SIT1, SIT, Signaling threshold-regulating transmembrane adapter 1,
 Catalog #  Product Name  Catalog #  Product Name
 MBS9222002  SIT1 Antibody (C-term) Blocking Peptide  MBS9203902  SIT1 Antibody (C-term)
 MBS2079377  APC/CY7-Linked Polyclonal Antibody to Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1)  MBS427225  SIT1 Immunizing Peptide
 MBS2014348  Polyclonal Antibody to Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1)  MBS422320  Goat anti-SIT1 Antibody
 MBS1225182  Recombinant Saccharomyces cerevisiae Siderophore iron transporter 1 (SIT1)  MBS2018337  Recombinant Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1)
 MBS8249798  Recombinant Human SIT1 Protein  MBS6004817  SIT1, CT (SIT1, SIT, Signaling threshold-regulating transmembrane adapter 1, SHP2-interacting transm...
Products associated with anti-SLC6A20 antibodyPathways associated with anti-SLC6A20 antibody
 Reference Product  PubMed Publications
 SLC36A1 antibody  >2 publications with SLC6A20 and SLC36A1
 SLC36A2 antibody  >1 publications with SLC6A20 and SLC36A2
 Products by Pathway  Pathway Diagram
 Amino Acid Transport Across The Plasma Membrane Pathway antibodies  Amino Acid Transport Across The Plasma Membrane Pathway Diagram
 Na+/Cl- Dependent Neurotransmitter Transporters Pathway antibodies  Na+/Cl- Dependent Neurotransmitter Transporters Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway antibodies  Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway Diagram
 Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies  Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram
Diseases associated with anti-SLC6A20 antibodyOrgans/Tissues associated with anti-SLC6A20 antibody
 Disease Name  Pubmed Publications
 Iminoglycinuria Antibodies  >4 publications with SLC6A20 and Iminoglycinuria
 Weight Loss Antibodies  >2 publications with SLC6A20 and Weight Loss
 Neoplasms Antibodies  >2 publications with SLC6A20 and Neoplasms
 Kidney Diseases Antibodies  >1 publications with SLC6A20 and Kidney Diseases
 Weight Gain Antibodies  >1 publications with SLC6A20 and Weight Gain
 Urinary Bladder Neoplasms Antibodies  >1 publications with SLC6A20 and Urinary Bladder Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with SLC6A20 and Neoplasms, Experimental
 HYPERGLYCINURIA Antibodies  >1 publications with SLC6A20 and HYPERGLYCINURIA
 Mesothelioma Antibodies  >1 publications with SLC6A20 and Mesothelioma
 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >11 publications with SLC6A20 and Intestine
 Brain Antibodies  >6 publications with SLC6A20 and Brain
 Nerve Antibodies  >3 publications with SLC6A20 and Nerve
 Lung Antibodies  >2 publications with SLC6A20 and Lung
 Muscle Antibodies  >1 publications with SLC6A20 and Muscle
 Stomach Antibodies  >1 publications with SLC6A20 and Stomach
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