NP_036159
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,799 Da
NCBI Official Full Name
evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
NCBI Official Synonym Full Names
ECSIT homolog (Drosophila)
NCBI Official Synonym Symbols
NCBI Protein Information
evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
UniProt Protein Name
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
UniProt Synonym Protein Names
Protein SITPEC
UniProt Synonym Gene Names
UniProt Entry Name
ECSIT_MOUSE
UniProt Comments for SITPEC
ECSIT: Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development. Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase. Belongs to the ECSIT family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; Adaptor/scaffold
Cellular Component: nucleoplasm; transcription factor complex; mitochondrion; cytoplasm; nucleus
Molecular Function: signal transducer activity; protein binding; oxidoreductase activity, acting on NADH or NADPH; transcription factor activity
Biological Process: BMP signaling pathway; regulation of transcription from RNA polymerase II promoter; mesoderm formation; immune system process; transmembrane receptor protein serine/threonine kinase signaling pathway; innate immune response; regulation of oxidoreductase activity
Research Articles on SITPEC
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Products associated with anti-SITPEC antibody
Pathways associated with anti-SITPEC antibody
Diseases associated with anti-SITPEC antibody
Organs/Tissues associated with anti-SITPEC antibody
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