NP_005973.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 33 kD Predicted: 33 kDa
NCBI Official Full Name
homeobox protein SIX1
NCBI Official Synonym Full Names
SIX homeobox 1
NCBI Protein Information
homeobox protein SIX1
UniProt Protein Name
Homeobox protein SIX1
UniProt Synonym Protein Names
Sine oculis homeobox homolog 1
NCBI Summary for SIX1
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). [provided by RefSeq, Jul 2008]
UniProt Comments for SIX1
Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2 (). Regulates the expression of CCNA1.
Research Articles on SIX1
Precautions
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Products associated with anti-SIX1 antibody
Pathways associated with anti-SIX1 antibody
Diseases associated with anti-SIX1 antibody
Organs/Tissues associated with anti-SIX1 antibody
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