NP_001191016.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
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NCBI Official Full Name
small conductance calcium-activated potassium channel protein 3 isoform c
NCBI Official Synonym Full Names
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
NCBI Protein Information
small conductance calcium-activated potassium channel protein 3; SKCa 3
UniProt Protein Name
Small conductance calcium-activated potassium channel protein 3
UniProt Synonym Protein Names
KCa2.3
UniProt Synonym Gene Names
UniProt Entry Name
KCNN3_HUMAN
NCBI Summary for KCNN3
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
UniProt Comments for KCNN3
KCNN3: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. Belongs to the potassium channel KCNN family. KCa2.3/KCNN3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component: cell soma; integral to membrane; plasma membrane
Molecular Function: calmodulin binding; small conductance calcium-activated potassium channel activity
Biological Process: synaptic transmission
Research Articles on KCNN3
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Products associated with anti-KCNN3 antibody
Pathways associated with anti-KCNN3 antibody
Diseases associated with anti-KCNN3 antibody
Organs/Tissues associated with anti-KCNN3 antibody
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