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anti-SLC10A2 antibody :: Rabbit anti-Human SLC10A2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7005222
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SLC10A2, Polyclonal Antibody

★Popular Item★
 Also Known As   

SLC10A2 Antibody

 Product Synonym Names    Ileal sodium/bile acid cotransporter; Apical sodium-dependent bile acid transporter; ASBT; Ileal Na(+)/bile acid cotransporter; Ileal sodium-dependent bile acid transporter; IBAT; ISBT; Na(+)-dependent ileal bile acid transporter; Sodium/taurocholate cotransporting polypeptide; ileal; Solute carrier family 10 member 2; SLC10A2; ASBT; ISBT; NTCP2
 Product Gene Name   

anti-SLC10A2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601295
 3D Structure    ModBase 3D Structure for Q12908
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%,Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Ileal sodium/bile acid cotransporter protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-27493
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-SLC10A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SLC10A2 antibody

   Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism.
 Applications Tested/Suitable for anti-SLC10A2 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

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 Immunohistochemistry (IHC) of anti-SLC10A2 antibody    Immunohistochemistry of paraffin-embedded human endometrial carcinoma MBS7005222 at dilution 1:100
anti-SLC10A2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-SLC10A2 antibody    Immunofluorescent analysis of A431 cells using MBS7005222 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-SLC10A2 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for SLC10A2. It may not necessarily be applicable to this product.
 NCBI GI #    4506973
 NCBI GeneID    6555
 NCBI Accession #    NP_000443.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000452.2 [Other Products]
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 UniProt Primary Accession #    Q12908 [Other Products]
 UniProt Secondary Accession #    Q13839; A1L4F4 [Other Products]
 UniProt Related Accession #    Q12908 [Other Products]
 Molecular Weight    37,714 Da
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 NCBI Official Full Name    ileal sodium/bile acid cotransporter
 NCBI Official Synonym Full Names    solute carrier family 10 (sodium/bile acid cotransporter), member 2
 NCBI Official Symbol    SLC10A2 [Similar Products]
 NCBI Official Synonym Symbols   
ASBT; IBAT; ISBT; PBAM; NTCP2
[Similar Products]
 NCBI Protein Information    ileal sodium/bile acid cotransporter
 UniProt Protein Name    Ileal sodium/bile acid cotransporter
 UniProt Synonym Protein Names   
Apical sodium-dependent bile acid transporter; ASBT; Ileal Na(+)/bile acid cotransporter; Ileal sodium-dependent bile acid transporter; IBAT; ISBT; Na(+)-dependent ileal bile acid transporter; Sodium/taurocholate cotransporting polypeptide, ileal; Solute carrier family 10 member 2
 Protein Family    Ileal sodium/bile acid cotransporter
 UniProt Gene Name    SLC10A2 [Similar Products]
 UniProt Synonym Gene Names    ASBT; ISBT; NTCP2; ASBT; IBAT; ISBT [Similar Products]
 UniProt Entry Name    NTCP2_HUMAN
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 NCBI Summary for SLC10A2    This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG). [provided by RefSeq, Mar 2010]
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 UniProt Comments for SLC10A2    ASBT: Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism. Defects in SLC10A2 are a cause of primary bile acid malabsorption (PBAM). PBAM is an idiopathic intestinal disorder associated with congenital diarrhea, steatorrhea, interruption of the enterohepatic circulation of bile acids, and reduced plasma cholesterol levels. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 13q33

Cellular Component: apical plasma membrane; integral to plasma membrane; microvillus; plasma membrane

Molecular Function: bile acid:sodium symporter activity

Biological Process: bile acid and bile salt transport; bile acid metabolic process; sodium ion transport; transmembrane transport; transport

Disease: Bile Acid Malabsorption, Primary
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 Research Articles on SLC10A2    1. Results unravel novel roles for N-glycosylation of ASBT and suggest that high levels of glucose alter the composition of the glycan and may contribute to the increase in ASBT function in diabetes mellitus.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SLC10A2 antibodyPathways associated with anti-SLC10A2 antibody
 Reference Product  PubMed Publications
 CYP7A1 antibody  >7 publications with SLC10A2 and CYP7A1
 ABCB11 antibody  >3 publications with SLC10A2 and ABCB11
 ABCC3 antibody  >3 publications with SLC10A2 and ABCC3
 NR1H4 antibody  >2 publications with SLC10A2 and NR1H4
 HNF1A antibody  >2 publications with SLC10A2 and HNF1A
 FABP6 antibody  >2 publications with SLC10A2 and FABP6
 Products by Pathway  Pathway Diagram
 Bile Acid And Bile Salt Metabolism Pathway antibodies  Bile Acid And Bile Salt Metabolism Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Recycling Of Bile Acids And Salts Pathway antibodies  Recycling Of Bile Acids And Salts Pathway Diagram
Diseases associated with anti-SLC10A2 antibodyOrgans/Tissues associated with anti-SLC10A2 antibody
 Disease Name  Pubmed Publications
 Cholestasis Antibodies  >7 publications with SLC10A2 and Cholestasis
 Liver Diseases Antibodies  >6 publications with SLC10A2 and Liver Diseases
 Disease Models, Animal Antibodies  >4 publications with SLC10A2 and Disease Models, Animal
 Kidney Diseases Antibodies  >3 publications with SLC10A2 and Kidney Diseases
 Inflammation Antibodies  >3 publications with SLC10A2 and Inflammation
 Dyslipidemias Antibodies  >3 publications with SLC10A2 and Dyslipidemias
 Fatty Liver Antibodies  >2 publications with SLC10A2 and Fatty Liver
 Fibrosis Antibodies  >1 publications with SLC10A2 and Fibrosis
 Hyperplasia Antibodies  >1 publications with SLC10A2 and Hyperplasia
 Lung Neoplasms Antibodies  >1 publications with SLC10A2 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >34 publications with SLC10A2 and Intestine
 Kidney Antibodies  >7 publications with SLC10A2 and Kidney
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