NP_000443.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
ileal sodium/bile acid cotransporter
NCBI Official Synonym Full Names
solute carrier family 10 (sodium/bile acid cotransporter), member 2
NCBI Protein Information
ileal sodium/bile acid cotransporter
UniProt Protein Name
Ileal sodium/bile acid cotransporter
UniProt Synonym Protein Names
Apical sodium-dependent bile acid transporter; ASBT; Ileal Na(+)/bile acid cotransporter; Ileal sodium-dependent bile acid transporter; IBAT; ISBT; Na(+)-dependent ileal bile acid transporter; Sodium/taurocholate cotransporting polypeptide, ileal; Solute carrier family 10 member 2
UniProt Synonym Gene Names
UniProt Entry Name
NTCP2_HUMAN
NCBI Summary for SLC10A2
This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG). [provided by RefSeq, Mar 2010]
UniProt Comments for SLC10A2
ASBT: Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism. Defects in SLC10A2 are a cause of primary bile acid malabsorption (PBAM). PBAM is an idiopathic intestinal disorder associated with congenital diarrhea, steatorrhea, interruption of the enterohepatic circulation of bile acids, and reduced plasma cholesterol levels. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter
Chromosomal Location of Human Ortholog: 13q33
Cellular Component: apical plasma membrane; integral to plasma membrane; microvillus; plasma membrane
Molecular Function: bile acid:sodium symporter activity
Biological Process: bile acid and bile salt transport; bile acid metabolic process; sodium ion transport; transmembrane transport; transport
Disease: Bile Acid Malabsorption, Primary
Research Articles on SLC10A2
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Products associated with anti-SLC10A2 antibody
Pathways associated with anti-SLC10A2 antibody
Diseases associated with anti-SLC10A2 antibody
Organs/Tissues associated with anti-SLC10A2 antibody
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