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anti-SLC12A1 antibody :: Goat SLC12A1 / NKCC2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS244408
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SLC12A1 / NKCC2, Polyclonal Antibody

 Also Known As   

Goat Polyclonal to Human SLC12A1 / NKCC2

 Product Synonym Names    Anti-SLC12A1 / NKCC2 Antibody (aa43-57) IHC-plus; SLC12A1; BSC1; MBSC1; Na-K-2Cl cotransporter; NKCC2A variant A; RBSC; NKCC2; Human SLC12A1; NKCC2
 Product Gene Name   

anti-SLC12A1 antibody

[Similar Products]
 Product Synonym Gene Name    NKCC2 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 601678
 3D Structure    ModBase 3D Structure for Q13621
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Gorilla, Human, Monkey
Predicted Reactivity: Orangutan, Gibbon, Mouse, Rat, Bat, Hamster (at least 90% immunogen sequence identity)
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 Specificity    Human SLC12A1.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide C-PHYEETSFGDEAQKR from an internal region of human SLC12A1 (NP_000329.2). Percent identity by BLAST analysis: Human, Gorilla, Monkey, Marmoset (100%); Orangutan, Gibbon, Mouse, Rat, Hamster, Bat (93%).
 Immunogen Type    Synthetic peptide
 Immunogen    SLC12A1 / NKCC2 antibody was raised against synthetic peptide C-PHYEETSFGDEAQKR from an internal region of human SLC12A1 (NP_000329.2). Percent identity by BLAST analysis: Human, Gorilla, Monkey, Marmoset (100%); Orangutan, Gibbon, Mouse, Rat, Hamster, Bat (93%); Panda, Bovine, Dog, Rabbit, Horse, Pig, Platypus (87%); Ferret, Elephant, Opossum (80%).
 Antigen Modification    aa43-57
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 Preparation and Storage    Store at -20 degree C. Minimize freezing and thawing.
 Other Notes    Small volumes of anti-SLC12A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-SLC12A1 antibody

   The sodium-potassium-chloride cotransporter isoform 2 is kidney-specific and is found on the apical membrane of the thick ascending limb of Henle's loop and the macula densa. It accounts for most of the NaCl resorption with the stoichiometry of 1Na:1K:2Cl and is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene.
 Product Categories/Family for anti-SLC12A1 antibody    Family: Transporter
Subfamily: Cation:chloride symporter
 Applications Tested/Suitable for anti-SLC12A1 antibody   

Immunohistochemistry (IHC - Paraffin)

 Application Notes for anti-SLC12A1 antibody    IHC-P (3.75 - 7.5 ug/ml)
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 Immunohistochemistry (IHC) of anti-SLC12A1 antibody    Anti-SLC12A1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
anti-SLC12A1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for SLC12A1. It may not necessarily be applicable to this product.
 NCBI GI #    134254459
 NCBI GeneID    6557
 NCBI Accession #    NP_000329.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000338.2 [Other Products]
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 UniProt Primary Accession #    Q13621 [Other Products]
 UniProt Secondary Accession #    A8JYA2; E9PDW4 [Other Products]
 UniProt Related Accession #    Q13621 [Other Products]
 Molecular Weight    – Da
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 NCBI Official Full Name    solute carrier family 12 member 1 isoform A
 NCBI Official Synonym Full Names    solute carrier family 12 (sodium/potassium/chloride transporter), member 1
 NCBI Official Symbol    SLC12A1 [Similar Products]
 NCBI Official Synonym Symbols   
BSC1; NKCC2
[Similar Products]
 NCBI Protein Information    solute carrier family 12 member 1; NKCC2A variant A; Na-K-2Cl cotransporter; kidney-specific Na-K-Cl symporter; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; solute carrier family 12 (sodium/potassium/chloride transporters), member 1
 UniProt Protein Name    Solute carrier family 12 member 1
 UniProt Synonym Protein Names   
Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; Kidney-specific Na-K-Cl symporter
 Protein Family    Solute carrier family
 UniProt Gene Name    SLC12A1 [Similar Products]
 UniProt Synonym Gene Names    NKCC2 [Similar Products]
 UniProt Entry Name    S12A1_HUMAN
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 NCBI Summary for SLC12A1    This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.[provided by RefSeq, May 2010]
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 UniProt Comments for SLC12A1    NKCC2: Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. Kidney specific. Activated by WNK3. Belongs to the SLC12A transporter family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, SLC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 15q15-q21.1

Cellular Component: membrane; apical plasma membrane; integral to membrane; plasma membrane

Molecular Function: sodium:potassium:chloride symporter activity

Biological Process: transport; sodium ion transport; ion transport; chloride transport; excretion; kidney development; transmembrane transport; potassium ion transport; chemical homeostasis

Disease: Bartter Syndrome, Antenatal, Type 1
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 Research Articles on SLC12A1    1. The association between polymorphisms in KCNJ1, SLC12A1, and 7 other genes and calcium intake and colorectal neoplasia risk was studied.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SLC12A1 antibodyPathways associated with anti-SLC12A1 antibody
 Reference Product  PubMed Publications
 AQP2 antibody  >46 publications with SLC12A1 and AQP2
 KCNJ1 antibody  >40 publications with SLC12A1 and KCNJ1
 CLCNKB antibody  >16 publications with SLC12A1 and CLCNKB
 STK39 antibody  >15 publications with SLC12A1 and STK39
 WNK4 antibody  >10 publications with SLC12A1 and WNK4
 BSND antibody  >8 publications with SLC12A1 and BSND
 WNK3 antibody  >6 publications with SLC12A1 and WNK3
 Products by Pathway  Pathway Diagram
 Cation-coupled Chloride Cotransporters Pathway antibodies  Cation-coupled Chloride Cotransporters Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies  Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram
Diseases associated with anti-SLC12A1 antibodyOrgans/Tissues associated with anti-SLC12A1 antibody
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >78 publications with SLC12A1 and Kidney Diseases
 Hypertension Antibodies  >76 publications with SLC12A1 and Hypertension
 Cardiovascular Diseases Antibodies  >57 publications with SLC12A1 and Cardiovascular Diseases
 Bartter Syndrome Antibodies  >40 publications with SLC12A1 and Bartter Syndrome
 Disease Models, Animal Antibodies  >28 publications with SLC12A1 and Disease Models, Animal
 Hypokalemia Antibodies  >25 publications with SLC12A1 and Hypokalemia
 Polyuria Antibodies  >22 publications with SLC12A1 and Polyuria
 Renal Insufficiency Antibodies  >13 publications with SLC12A1 and Renal Insufficiency
 Nervous System Diseases Antibodies  >13 publications with SLC12A1 and Nervous System Diseases
 Hypotension Antibodies  >7 publications with SLC12A1 and Hypotension
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >243 publications with SLC12A1 and Kidney
 Vascular Antibodies  >25 publications with SLC12A1 and Vascular
 Brain Antibodies  >14 publications with SLC12A1 and Brain
 Muscle Antibodies  >8 publications with SLC12A1 and Muscle
 Lung Antibodies  >8 publications with SLC12A1 and Lung
 Parathyroid Antibodies  >7 publications with SLC12A1 and Parathyroid
 Liver Antibodies  >6 publications with SLC12A1 and Liver
 Bone Antibodies  >6 publications with SLC12A1 and Bone
 Intestine Antibodies  >5 publications with SLC12A1 and Intestine
 Eye Antibodies  >4 publications with SLC12A1 and Eye
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