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anti-SLC17A7 antibody :: Goat SLC17A7 / BNPI / VGLUT1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS243639
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SLC17A7 / BNPI / VGLUT1, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat Polyclonal to Human SLC17A7 / BNPI / VGLUT1

 Product Synonym Names    Anti-SLC17A7 / BNPI / VGLUT1 Antibody IHC-plus; SLC17A7; BNPI; VGLUT1; Human SLC17A7; BNPI; VGLUT1
 Product Gene Name   

anti-SLC17A7 antibody

[Similar Products]
 Product Synonym Gene Name    BNPI; VGLUT1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605208
 3D Structure    ModBase 3D Structure for Q9P2U7
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Human
Predicted Reactivity: Monkey, Mouse, Rat, Bovine, Pig, Rabbit
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 Specificity    Human SLC17A7 / VGLUT1.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide C-HDQLAGSDDSEMED from an internal region of human SLC17A7 / VGLUT1 (NP_064705.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Elephant (100%); Marmoset, Mouse, Rat, Panda, Bovine, Rabbit, Pig (93%).
 Immunogen Type    Synthetic peptide
 Immunogen    SLC17A7 / BNPI / VGLUT1 antibody was raised against synthetic peptide C-HDQLAGSDDSEMED from an internal region of human SLC17A7 / VGLUT1 (NP_064705.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Elephant (100%); Marmoset, Mouse, Rat, Panda, Bovine, Rabbit, Pig (93%); Hamster, Dog, Horse (86%).
 Usage    Immunohistochemistry: MBS243639 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for MBS243639 was determined to be 3.75ug/ml.
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
 Other Notes    Small volumes of anti-SLC17A7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-SLC17A7 antibody    Family: Transporter
Subfamily: Sodium:phosphate symporter
 Applications Tested/Suitable for anti-SLC17A7 antibody   

Immunohistochemistry (IHC - Paraffin)

 Application Notes for anti-SLC17A7 antibody    IHC-P (3.75 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-SLC17A7 antibody    Anti-SLC17A7 / VGLUT1 antibody IHC of human adrenal cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
anti-SLC17A7 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for SLC17A7. It may not necessarily be applicable to this product.
 NCBI GI #    9945322
 NCBI GeneID    57030
 NCBI Accession #    NP_064705.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_020309.3 [Other Products]
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 UniProt Primary Accession #    Q9P2U7 [Other Products]
 UniProt Secondary Accession #    Q6PCD0; B4DFR9; B4DG46 [Other Products]
 UniProt Related Accession #    Q9P2U7 [Other Products]
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 NCBI Official Full Name    vesicular glutamate transporter 1
 NCBI Official Synonym Full Names    solute carrier family 17 (vesicular glutamate transporter), member 7
 NCBI Official Symbol    SLC17A7 [Similar Products]
 NCBI Official Synonym Symbols   
BNPI; VGLUT1
[Similar Products]
 NCBI Protein Information    vesicular glutamate transporter 1; solute carrier family 17 member 7; brain-specific Na-dependent inorganic phosphate cotransporter; brain-specific Na(+)-dependent inorganic phosphate cotransporter; solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
 UniProt Protein Name    Vesicular glutamate transporter 1
 UniProt Synonym Protein Names   
Brain-specific Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 7
 Protein Family    Vesicular glutamate transporter
 UniProt Gene Name    SLC17A7 [Similar Products]
 UniProt Synonym Gene Names    BNPI; VGLUT1; VGluT1 [Similar Products]
 UniProt Entry Name    VGLU1_HUMAN
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 NCBI Summary for SLC17A7    The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SLC17A7    SLC17A7: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.

Protein type: Transporter, SLC family; Membrane protein, multi-pass; Vesicle; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 19q13

Cellular Component: synaptic vesicle membrane; integral to membrane; presynaptic active zone; plasma membrane; excitatory synapse; cell junction

Molecular Function: sodium:inorganic phosphate symporter activity; sodium-dependent phosphate transmembrane transporter activity; inorganic phosphate transmembrane transporter activity; L-glutamate transmembrane transporter activity

Biological Process: synaptic transmission; synaptic transmission, glutamatergic; L-glutamate import; glutamate secretion; phosphate transport; long-term memory; neurotransmitter secretion; ion transport; regulation of excitatory postsynaptic membrane potential; sequestering of neurotransmitter; transmembrane transport
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 Research Articles on SLC17A7    1. Depressed patients showed significant decreases in synaptophysin (SYN) and VGLUT1 expression, whereas in bipolar patients, decreases in VGLUT1 expression have also been found.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SLC17A7 antibodyPathways associated with anti-SLC17A7 antibody
 Reference Product  PubMed Publications
 SLC32A1 antibody  >4 publications with SLC17A7 and SLC32A1
 VAMP2 antibody  >2 publications with SLC17A7 and VAMP2
 KCNC3 antibody  >1 publications with SLC17A7 and KCNC3
 UNC13B antibody  >1 publications with SLC17A7 and UNC13B
 RAB3A antibody  >1 publications with SLC17A7 and RAB3A
 Products by Pathway  Pathway Diagram
 Glutamate Neurotransmitter Release Cycle Pathway antibodies  Glutamate Neurotransmitter Release Cycle Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Release Cycle Pathway antibodies  Neurotransmitter Release Cycle Pathway Diagram
 Nicotine Addiction Pathway antibodies  Nicotine Addiction Pathway Diagram
 Nicotine Addiction Pathway antibodies  Nicotine Addiction Pathway Diagram
 Organic Anion Transporters Pathway antibodies  Organic Anion Transporters Pathway Diagram
 Retrograde Endocannabinoid Signaling Pathway antibodies  Retrograde Endocannabinoid Signaling Pathway Diagram
 Retrograde Endocannabinoid Signaling Pathway antibodies  Retrograde Endocannabinoid Signaling Pathway Diagram
Diseases associated with anti-SLC17A7 antibodyOrgans/Tissues associated with anti-SLC17A7 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >45 publications with SLC17A7 and Nervous System Diseases
 Mental Disorders Antibodies  >40 publications with SLC17A7 and Mental Disorders
 Learning Disorders Antibodies  >12 publications with SLC17A7 and Learning Disorders
 Epilepsy Antibodies  >11 publications with SLC17A7 and Epilepsy
 Pain Antibodies  >10 publications with SLC17A7 and Pain
 Memory Disorders Antibodies  >10 publications with SLC17A7 and Memory Disorders
 Neurobehavioral Manifestations Antibodies  >8 publications with SLC17A7 and Neurobehavioral Manifestations
 Cognition Disorders Antibodies  >6 publications with SLC17A7 and Cognition Disorders
 Seizures Antibodies  >6 publications with SLC17A7 and Seizures
 Nerve Degeneration Antibodies  >5 publications with SLC17A7 and Nerve Degeneration
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >260 publications with SLC17A7 and Brain
 Eye Antibodies  >21 publications with SLC17A7 and Eye
 Muscle Antibodies  >19 publications with SLC17A7 and Muscle
 Bone Antibodies  >8 publications with SLC17A7 and Bone
 Embryonic Tissue Antibodies  >8 publications with SLC17A7 and Embryonic Tissue
 Skin Antibodies  >4 publications with SLC17A7 and Skin
 Pineal Gland Antibodies  >3 publications with SLC17A7 and Pineal Gland
 Lung Antibodies  >2 publications with SLC17A7 and Lung
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