Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow SLC22A12 rightarrow Polyclonal SLC22A12  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Thyroid Stimulating Hormone (TSH) ELISA Kit
 • Cadherin 5 (CDH5) ELISA Kit
 • Collagen Type I (COL1) ELISA Kit
 • S100 Calcium Binding Protein ELISA Kit
 • RNH1 Blocking Peptide
 • N-Terminal Pro Brain Natriuretic Peptide (NT-ProBNP) ELISA Kit
 • BMP8 Antibody
 • TGFbeta3 Antibody
 • alpha-L-iduronidase (IDUA) ELISA Kit
 • ACTIN F TYPE (ACTG1) Antibody
 • Netrin-1 (NTN1) ELISA Kit
 • Olfactory Marker Protein (OMP) Recombinant Protein
 • ENG ELISA Kit
 • HIV-1 nef Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-SLC22A12 antibody :: Rabbit anti-Human SLC22A12 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2529149
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SLC22A12, Polyclonal Antibody

★Popular Item★
 Also Known As   

SLC22A12 Polyclonal Antibody

 Product Synonym Names    RST; OAT4L; URAT1
 Product Gene Name   

anti-SLC22A12 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    220150
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
Section Bar
 Purity/Purification    Affinity purification
 Concentration    0.3mg/mL (lot specific)
Section Bar
Section Bar
 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-SLC22A12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-SLC22A12 antibody

   Background/Introduction: The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants.
 Applications Tested/Suitable for anti-SLC22A12 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-SLC22A12 antibody    WB: 1:200-1:1000
IHC: 1:25-1:100
Section Bar
 Western Blot (WB) of anti-SLC22A12 antibody    Western Blot analysis of Hela and 293T cell using SLC22A12 Polyclonal Antibody at dilution of 1:200
anti-SLC22A12 antibody Western Blot (WB) (WB) image
Section Bar
 Immunohistochemistry (IHC) of anti-SLC22A12 antibody    Immunohistochemistry of paraffin-embedded Human liver cancer using SLC22A12 Polyclonal Antibody at dilution of 1:20
anti-SLC22A12 antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunohistochemistry (IHC) of anti-SLC22A12 antibody    Immunohistochemistry of paraffin-embedded Human brain using SLC22A12 Polyclonal Antibody at dilution of 1:20
anti-SLC22A12 antibody Immunohistochemistry (IHC) (IHC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for SLC22A12. It may not necessarily be applicable to this product.
 NCBI GI #    444299638
 NCBI GeneID    116085
 NCBI Accession #    NP_001263256.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001276327.1 [Other Products]
Section Bar
 UniProt Secondary Accession #    Q19PF7; Q19PF8; Q19PF9; Q19PG0; Q6UXW3; Q96DT2; B7WPG1; G3XAN7 [Other Products]
 UniProt Related Accession #    Q96S37 [Other Products]
Table BarTOPTable Bar
 NCBI Official Full Name    solute carrier family 22 member 12 isoform d
 NCBI Official Synonym Full Names    solute carrier family 22 (organic anion/urate transporter), member 12
 NCBI Official Symbol    SLC22A12 [Similar Products]
 NCBI Official Synonym Symbols   
RST; OAT4L; URAT1
[Similar Products]
 NCBI Protein Information    solute carrier family 22 member 12; organic anion transporter 4-like protein; renal-specific transporter; solute carrier family 22 (organic anion/cation transporter), member 12; urate anion exchanger 1; urate transporter 1
 UniProt Protein Name    Solute carrier family 22 member 12
 UniProt Synonym Protein Names   
Organic anion transporter 4-like protein; Renal-specific transporter; RST; Urate anion exchanger 1
 Protein Family    Solute carrier family
 UniProt Gene Name    SLC22A12 [Similar Products]
 UniProt Synonym Gene Names    OATL4; URAT1; RST [Similar Products]
 UniProt Entry Name    S22AC_HUMAN
Section Bar
 NCBI Summary for SLC22A12    The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Section Bar
 UniProt Comments for SLC22A12    SLC22A12: Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions. Defects in SLC22A12 are the cause of hypouricemia renal type 1 (RHUC1). A disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and nephrolithiasis. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family; Transporter

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: brush border membrane; apical plasma membrane; integral to membrane; plasma membrane

Molecular Function: urate transmembrane transporter activity; PDZ domain binding

Biological Process: response to drug; urate transport; urate metabolic process; cellular homeostasis; organic acid transport; transmembrane transport

Disease: Hypouricemia, Renal, 1
Table BarTOPTable Bar
 Research Articles on SLC22A12    1. Our analysis provides evidence for multiple ancestral-specific effects across the SLC22A11/SLC22A12 locus that presumably influence the activity of OAT4 and URAT1 and risk of gout.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-SLC22A12 antibodyPathways associated with anti-SLC22A12 antibody
 Reference Product  PubMed Publications
 PDZK1 antibody  >13 publications with SLC22A12 and PDZK1
 SLC17A1 antibody  >12 publications with SLC22A12 and SLC17A1
 SLC17A3 antibody  >10 publications with SLC22A12 and SLC17A3
 SLC16A9 antibody  >8 publications with SLC22A12 and SLC16A9
 SLC5A8 antibody  >4 publications with SLC22A12 and SLC5A8
 SLC5A12 antibody  >2 publications with SLC22A12 and SLC5A12
 Products by Pathway  Pathway Diagram
 Organic Anion Transport Pathway antibodies  Organic Anion Transport Pathway Diagram
 Organic Cation/anion/zwitterion Transport Pathway antibodies  Organic Cation/anion/zwitterion Transport Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway antibodies  Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway Diagram
Diseases associated with anti-SLC22A12 antibodyOrgans/Tissues associated with anti-SLC22A12 antibody
 Disease Name  Pubmed Publications
 Hyperuricemia Antibodies  >80 publications with SLC22A12 and Hyperuricemia
 Kidney Diseases Antibodies  >77 publications with SLC22A12 and Kidney Diseases
 Gout Antibodies  >60 publications with SLC22A12 and Gout
 Renal hypouricemia Antibodies  >55 publications with SLC22A12 and Renal hypouricemia
 Renal Insufficiency Antibodies  >33 publications with SLC22A12 and Renal Insufficiency
 Acute Kidney Injury Antibodies  >29 publications with SLC22A12 and Acute Kidney Injury
 Hypertension Antibodies  >23 publications with SLC22A12 and Hypertension
 Liver Diseases Antibodies  >9 publications with SLC22A12 and Liver Diseases
 Brain Diseases Antibodies  >5 publications with SLC22A12 and Brain Diseases
 Proteinuria Antibodies  >2 publications with SLC22A12 and Proteinuria
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >134 publications with SLC22A12 and Kidney
 Mixed Antibodies  >1 publications with SLC22A12 and Mixed
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions