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anti-SLC22A8 antibody :: Rabbit anti-Human, Mouse SLC22A8 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7044950
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

SLC22A8, Polyclonal Antibody

★Popular Item★
 Also Known As   

SLC22A8 Antibody

 Product Synonym Names    Solute carrier family 22 member 8; Organic anion transporter 3; hOAT3; SLC22A8; OAT3
 Product Gene Name   

anti-SLC22A8 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607581
 3D Structure    ModBase 3D Structure for Q8TCC7
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Antigen Affinity Purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Solute carrier family 22 member 8 protein (C-70AA)
 Conjugate    Non-conjugated
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-107836
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-SLC22A8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SLC22A8 antibody

   Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).
 Applications Tested/Suitable for anti-SLC22A8 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-SLC22A8 antibody    Western blot
All lanes: SLC22A8antibody IgG at 1.62ug/ml+ Mouse kidney tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 60,61,47,12,50 kDa
Observed band size: 60 kDa

anti-SLC22A8 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-SLC22A8 antibody    Immunohistochemistry of paraffin-embedded human kidney tissue MBS7044950 at dilution 1:100
anti-SLC22A8 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-SLC22A8 antibody    Immunohistochemistry of paraffin-embedded human adrenal gland tissue MBS7044950 at dilution 1:100
anti-SLC22A8 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for SLC22A8. It may not necessarily be applicable to this product.
 NCBI GI #    296080719
 NCBI GeneID    9376
 NCBI Accession #    NP_001171661.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001184732.1 [Other Products]
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 UniProt Primary Accession #    Q8TCC7 [Other Products]
 UniProt Secondary Accession #    O95820; Q59EW9; Q96TC1; B4DPH7; F5GWA8; F5H5J1 [Other Products]
 UniProt Related Accession #    Q8TCC7 [Other Products]
 Molecular Weight    49,821 Da
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 NCBI Official Full Name    solute carrier family 22 member 8 isoform 1
 NCBI Official Synonym Full Names    solute carrier family 22 member 8
 NCBI Official Symbol    SLC22A8 [Similar Products]
 NCBI Official Synonym Symbols   
OAT3
[Similar Products]
 NCBI Protein Information    solute carrier family 22 member 8
 UniProt Protein Name    Solute carrier family 22 member 8
 UniProt Synonym Protein Names   
Organic anion transporter 3; hOAT3
 Protein Family    Solute carrier family
 UniProt Gene Name    SLC22A8 [Similar Products]
 UniProt Synonym Gene Names    OAT3; hOAT3 [Similar Products]
 UniProt Entry Name    S22A8_HUMAN
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 NCBI Summary for SLC22A8    This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, May 2010]
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 UniProt Comments for SLC22A8    SLC22A8: Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA). Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family

Chromosomal Location of Human Ortholog: 11q11

Cellular Component: basolateral plasma membrane; integral to plasma membrane; plasma membrane

Molecular Function: anion:anion antiporter activity; inorganic anion exchanger activity; sodium-independent organic anion transmembrane transporter activity

Biological Process: sodium-independent organic anion transport
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 Research Articles on SLC22A8    1. The putative promoter sequences from hOAT1 (SLC22A6) and hOAT3 (SCL22A8) were cloned into a reporter plasmid.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-SLC22A8 antibodyDiseases associated with anti-SLC22A8 antibody
 Products by Pathway  Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Organic Anion Transport Pathway antibodies  Organic Anion Transport Pathway Diagram
 Organic Cation/anion/zwitterion Transport Pathway antibodies  Organic Cation/anion/zwitterion Transport Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway antibodies  Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway Diagram
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >7 publications with SLC22A8 and Hypertension
 Kidney Diseases Antibodies  >5 publications with SLC22A8 and Kidney Diseases
 Liver Diseases Antibodies  >3 publications with SLC22A8 and Liver Diseases
 Renal Insufficiency Antibodies  >2 publications with SLC22A8 and Renal Insufficiency
 Acute Kidney Injury Antibodies  >2 publications with SLC22A8 and Acute Kidney Injury
 Brain Diseases Antibodies  >1 publications with SLC22A8 and Brain Diseases
 Liver Neoplasms Antibodies  >1 publications with SLC22A8 and Liver Neoplasms
 Inflammation Antibodies  >1 publications with SLC22A8 and Inflammation
 Influenza, Human Antibodies  >1 publications with SLC22A8 and Influenza, Human
 Heart Failure Antibodies  >1 publications with SLC22A8 and Heart Failure
Organs/Tissues associated with anti-SLC22A8 antibody
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >53 publications with SLC22A8 and Kidney
 Brain Antibodies  >18 publications with SLC22A8 and Brain
 Eye Antibodies  >3 publications with SLC22A8 and Eye
 Uncharacterized Tissue Antibodies  >1 publications with SLC22A8 and Uncharacterized Tissue
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